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Cat. No.	Product Name	Target	Signaling Pathways
T0209	Loperamide hydrochloride Loperamide HCl,R-18553 (hydrochloride),ADL 2-1294,盐酸洛哌丁胺	Opioid Receptor; Autophagy	Autophagy; Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Loperamide hydrochloride (ADL 2-1294) 是一种合成的哌啶衍生物和阿片样物质激动剂，具有止泻活性。
T38809	Loperamide phenyl
	Loperamide phenyl, an impurity detected in Loperamide, is an opioid receptor agonist.
T33615	N-Desmethyl Loperamide dLop,R20905,R-20905,R 20905
	N-Desmethyl Loperamide is the major metabolite of loperamide. It is also used as the precusor for radiolabelled loperamide.
T25753	Loperamide oxide R 58425,R58425,R-58425
	Loperamide oxide is a prodrug of loperamide, the effective antidiarrheal.
T11867	Loperamide-d6 hydrochloride R-18553 D6 hydrochloride	Others	Others
	Loperamide D6 hydrochloride, a deuterium-labeled variant of Loperamide hydrochloride, acts as an opioid receptor agonist utilized for diarrhea treatment.
T83899	N-didesmethyl Loperamide R 21345
	N-didesmethyl Loperamide是loperamide的一个活性代谢产物，属于周围μ1-阿片受体激动剂。它能抑制孤立的豚鼠肠膜丛中由电刺激引起的收缩(IC50 = 370 nM)。N-didesmethyl Loperamide还能增强对氯喹产生抗药性的P. falciparum菌株对氯喹的敏感性(EC50 = 482 nM)，同时在A-10血管平滑肌细胞中未引起毒性(IC50 = >10,000 nM)。
T70267	ADL 08-0011 HCl
	ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan. It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki = 0.25 nM). It is selective for μ-opioid receptors over κ- and δ-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4). In vivo, ADL 08-0011 (0.03-1 mg/kg) reverse...

化合物

Loperamide hydrochloride

Cat.No: T0209

Synonym: Loperamide HCl,R-18553 (hydrochloride),ADL 2-1294,盐酸洛哌丁胺

Target: Opioid Receptor, Autophagy

Loperamide phenyl

Cat.No: T38809

N-Desmethyl Loperamide

Cat.No: T33615

Synonym: dLop,R20905,R-20905,R 20905

Loperamide oxide

Cat.No: T25753

Synonym: R 58425,R58425,R-58425

Loperamide-d6 hydrochloride

Cat.No: T11867

Synonym: R-18553 D6 hydrochloride

Target: Others

N-didesmethyl Loperamide

Cat.No: T83899

Synonym: R 21345

ADL 08-0011 HCl

Cat.No: T70267

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