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Cat. No. Product Name Target Signaling Pathways
T4327 Prexasertib dihydrochloride

LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368

Apoptosis; Chk; S6 Kinase Apoptosis; Cell Cycle/Checkpoint; MAPK; PI3K/Akt/mTOR signaling
Prexasertib dihydrochloride (LY2606368) 是一种选择性的,ATP 竞争性的细胞周期检测点激酶 1 抑制剂,Ki 为 0.9 nM,IC50为 <1 nM。它抑制 CHK2(IC50=8 nM) 和 RSK1 (IC50=9 nM)。它引起双链 DNA 断裂和复制突变,导致细胞凋亡,有抗肿瘤活性。
T22957 LY2606368 HCl (1234015-52-1 free base)

LY2606368 HCl

Others Others
LY2606368 HCl is a selective ATP competitive inhibitor of checkpoint kinase 1 (IC50: 1.5nM in SW1990 cells).

化合物

Prexasertib dihydrochloride
Cat.No: T4327
Synonym: LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368
Target: Apoptosis, Chk, S6 Kinase
LY2606368 HCl (1234015-52-1 free base)
Cat.No: T22957
Synonym: LY2606368 HCl
Target: Others
TargetMol Loading
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