Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T67871 |
LSD1-IN-24
|
Histone Demethylase; PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Immunology/Inflammation |
LSD1-IN-24 是一种具有选择性和有效性的 LSD1 抑制剂,IC50 值为 0.247 μM。LSD1-IN-24 可诱导 PD-L1 的表达,加强 T 细胞杀伤反应,可用于癌症相关疾病。 | |||
T36668 | Geranylgeranoic Acid | ||
Geranylgeranoic acid (GGA) is an isoprenoid that has been found inS. chinensisand has anticancer activity.1It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not primary mouse hepatocytes, when used at concentrations ranging from 1 to 20 μM. GGA (10 μM) induces apoptosis in Huh7 cellsvialoss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32).2It also... |