Cat. No. | Product Name | Target | Signaling Pathways |
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T63057 |
LRRK2-IN-5
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LRRK2-IN-5 (compound 25) 是一种口服具有活力的、能透过血脑屏障的、选择性富含亮氨酸重复蛋白激酶 2 基因 (LRRK2) 抑制剂,对 GS LRRK2 (IC50: 1.2 μM) 和 WT LRRK2 (IC50: 16 μM) 具有抑制作用。LRRK2-IN-5 能够抑制 LRRK2 Ser1292 和 Ser925 的自磷酸化。 | |||
T61527 |
GSK2646264
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GSK2646264 (Compound 44) is a highly effective and specific inhibitor of spleen tyrosine kinase (SYK) with a pIC50 of 7.1. In addition to targeting SYK, GSK2646264 also inhibits several other kinases, including LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B, and Aurora A, with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3, respectively. Notably, GSK2646264 demonstrates skin penetrability, reaching both the epidermis and dermis [1]. |