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Targets Recommended: Others

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T8591	RNase L-IN-2 5-(3-hydroxyphenyl)-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),5-trien-3-one	Others	Others
	RNase L-IN-2 是 RNase L 的激活剂，EC50 为 22 uM；对多种类型的 RNA 病毒（包括人类病原体人类副流感病毒 3 型）具有广谱抗病毒活性，在有效浓度下没有细胞毒性。
T38469	(Rac)-Z-Phe-Phe-FMK Cathepsin L-IN-2	Beta Amyloid; Cysteine Protease	Neuroscience; Proteases/Proteasome
	(Rac)-Z-Phe-Phe-FMK (Cathepsin L-IN-2) 是一种 cathepsin L 抑制剂，抑制 β-淀粉样蛋白诱导凋亡变化的倾向。(Rac)-Z-Phe-Phe-FMK 通过 siRNA 敲低 LC3B 表达可抑制 PI 诱导的 IkappaBalpha 降解。
T11850	LIN28 inhibitor LI71
	LIN28 inhibitor LI71 是一种有效的细胞渗透性 LIN28 抑制剂，可消除 LIN28 介导的寡尿苷酸化，IC50 为 7 uM。它能直接绑定 CSD，抑制 LIN28 对 let-7 的作用活性。
T11851	Lin28-let-7a antagonist 1	Others	Others
	Lin28-let-7a antagonist 1 对 Lin28A-let-7a-1 相互作用的 IC50 为 4.03 μM，对 Lin28-let-7a 相互作用有明显的拮抗作用。
T27835	Lin281632 Lin-28 1632,Lin-281632,Lin 281632,Lin28 1632,Lin 28 163
	Lin281632 是 RNA 结合蛋白 Lin28 和溴结构域的抑制剂。 Lin281632 促进 mESC 分化。
T41114	LIN28 inhibitor LI71 enantiomer
	LIN28 inhibitor LI71 enantiomer, the enantiomer of LIN28 inhibitor LI71，exhibits reduced activity compared to its parent compound. LIN28 inhibitor LI71 is a highly potent and cell-permeable inhibitor of LIN28, effectively blocking LIN28-mediated oligouridylation with an IC50 of 7 uM.
T81932	LIN28-IN-1
	LIN28-IN-1（compound 5）是针对RNA结合蛋白LIN28的抑制剂，可与LIN28的冷休克结构域（CSD）发生结合。该化合物能有效阻断LIN28与let-7miRNA的交互作用，具有显著的IC50值为5.4 μM，从而抑制LIN28在表观遗传学中的负向调控功能。此外，LIN28-IN-1在IC50为6.4 μM的条件下，显著抑制了过表达LIN28的JAR癌细胞的增殖。

化合物

RNase L-IN-2

Cat.No: T8591

Synonym: 5-(3-hydroxyphenyl)-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),5-trien-3-one

Target: Others

(Rac)-Z-Phe-Phe-FMK

Cat.No: T38469

Synonym: Cathepsin L-IN-2

Target: Beta Amyloid, Cysteine Protease

LIN28 inhibitor LI71

Cat.No: T11850

Synonym:

Target:

Lin28-let-7a antagonist 1

Synonym: Lin-28 1632,Lin-281632,Lin 281632,Lin28 1632,Lin 28 163

Target:

LIN28 inhibitor LI71 enantiomer

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04563	CASK Protein, Human, Recombinant (His & GST) calcium/calmodulin-dependent serine protein kinase ...	Human	Baculovirus-Insect Cells
	Peripheral plasma membrane protein CASK, also known as calcium/calmodulin-dependent serine protein kinase, CASK and LIN2, is a nucleus, cytoplasm and cell membrane protein which belongs to theMAGUK family. CASK / LIN2 contains oneguanylate kinase-like domain, twoL27 domains, onePDZ (DHR) domain, oneprotein kinase domain and oneSH3 domain. CASK / LIN2 is ubiquitously expressed. Expression of CASK / LIN2 is significantly greater in brain relative to kidney, lung, and liver and in fetal brai...
TMPY-04754	CASK Protein, Human, Recombinant CMG,LIN2,MRXSNA,CAMGUK,calcium/calmodu...	Human	Baculovirus-Insect Cells
	Peripheral plasma membrane protein CASK, also known as calcium/calmodulin-dependent serine protein kinase, CASK and LIN2, is a nucleus, cytoplasm and cell membrane protein which belongs to theMAGUK family. CASK / LIN2 contains oneguanylate kinase-like domain, twoL27 domains, onePDZ (DHR) domain, oneprotein kinase domain and oneSH3 domain. CASK / LIN2 is ubiquitously expressed. Expression of CASK / LIN2 is significantly greater in brain relative to kidney, lung, and liver and in fetal brai...
TMPH-01940	LIN28A Protein, Human, Recombinant (His)	Human	Yeast
	LIN28A Protein, Human, Recombinant (His) is expressed in Yeast.
TMPH-01939	LIN28A Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	LIN28A Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.