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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T81423	Polzastobart JTX 8064
	Polzastobart (JTX-8064) 为一种人源化IgG4单克隆抗体，特异性与LILRB2结合，阻断其与配体及MHC I分子（经典与非经典）的相互作用。此抗体通过抑制LILRB2与HLA-A/B和/或HLA-G（癌细胞免疫耐受的标志）的结合，可增强巨噬细胞产生促炎细胞因子。Polzastobart 作为巨噬细胞免疫检查点抑制剂发挥作用。

化合物

Polzastobart

Cat.No: T81423

Synonym: JTX 8064

Target:

Species：

Expression System：

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Cat. No.	Product Name	Species	Expression System
TMPK-01314	LILRB2/CD85d/ILT4 Protein, Cynomolgus, Recombinant (His) CD85d,ILT4CD85d,LIR2,MIR10,LILRB2...	Cynomolgus	HEK293 Cells
	The immunoglobulin-like transcript (ILT) comprise a family of activating and inhibitory type immunoreceptors whose genes are located in the same locus that encodes killer cell Ig-like receptors (KIR). ILT4, also known as LIR-2 and LILRB2, is a type I transmembrane protein expressed primarily on monocytes and dendritic cells (DC). LILRB2 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. LILRB2/CD85d/ILT4 Protein, Cynomolgus, Recom...
TMPK-01313	LILRB2/CD85d/ILT4 Protein, Cynomolgus, Recombinant (hFc) ILT-4,MIR10,ILT4,ILT4CD85d,LILRB2,LIR2...	Cynomolgus	HEK293 Cells
	The immunoglobulin-like transcript (ILT) comprise a family of activating and inhibitory type immunoreceptors whose genes are located in the same locus that encodes killer cell Ig-like receptors (KIR). ILT4, also known as LIR-2 and LILRB2, is a type I transmembrane protein expressed primarily on monocytes and dendritic cells (DC). LILRB2 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. LILRB2/CD85d/ILT4 Protein, Cynomolgus, Recom...
TMPK-01102	LILRB2/CD85d/ILT4 Protein, Human, Recombinant (mFc) ILT4,CD85d,ILT4CD85d,MIR10,LIR2,LILRB2...	Human	HEK293 Cells
	The immunoglobulin-like transcript (ILT) comprise a family of activating and inhibitory type immunoreceptors whose genes are located in the same locus that encodes killer cell Ig-like receptors (KIR). ILT4, also known as LIR-2 and LILRB2, is a type I transmembrane protein expressed primarily on monocytes and dendritic cells (DC). LILRB2 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. LILRB2/CD85d/ILT4 Protein, Human, Recombinan...
TMPK-01100	LILRB2/CD85d/ILT4 Protein, Human, Recombinant (hFc) CD85d,ILT-4,LILRB2,ILT4CD85d,ILT4,LIR2...	Human	HEK293 Cells
	The immunoglobulin-like transcript (ILT) comprise a family of activating and inhibitory type immunoreceptors whose genes are located in the same locus that encodes killer cell Ig-like receptors (KIR). ILT4, also known as LIR-2 and LILRB2, is a type I transmembrane protein expressed primarily on monocytes and dendritic cells (DC). LILRB2 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. LILRB2/CD85d/ILT4 Protein, Human, Recombinan...
TMPK-01098	LILRB2/CD85d/ILT4 Protein, Human, Recombinant (His & Avi) MIR10,CD85d,ILT-4,ILT4,ILT4CD85d,LILRB2,LI...	Human	HEK293 Cells
	The immunoglobulin-like transcript (ILT) comprise a family of activating and inhibitory type immunoreceptors whose genes are located in the same locus that encodes killer cell Ig-like receptors (KIR). ILT4, also known as LIR-2 and LILRB2, is a type I transmembrane protein expressed primarily on monocytes and dendritic cells (DC). LILRB2 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. LILRB2/CD85d/ILT4 Protein, Human, Recombinan...
TMPK-01101	LILRB2/CD85d/ILT4 Domain1 & 2 Protein, Human, Recombinant (His) LILRB2,ILT-4,CD85d,MIR10,LIR2,ILT...	Human	HEK293 Cells
	The immunoglobulin-like transcript (ILT) comprise a family of activating and inhibitory type immunoreceptors whose genes are located in the same locus that encodes killer cell Ig-like receptors (KIR). ILT4, also known as LIR-2 and LILRB2, is a type I transmembrane protein expressed primarily on monocytes and dendritic cells (DC). LILRB2 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. LILRB2/CD85d/ILT4 Domain1 & 2 Protein, Human...
TMPK-01099	LILRB2/CD85d/ILT4 Protein, Human, Recombinant (His & Avi), Biotinylated CD85d,LILRB2,MIR10,ILT4CD85d,ILT4,LIR2...	Human	HEK293 Cells
	The immunoglobulin-like transcript (ILT) comprise a family of activating and inhibitory type immunoreceptors whose genes are located in the same locus that encodes killer cell Ig-like receptors (KIR). ILT4, also known as LIR-2 and LILRB2, is a type I transmembrane protein expressed primarily on monocytes and dendritic cells (DC). LILRB2 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. LILRB2/CD85d/ILT4 Protein, Human, Recombinan...
TMPJ-00552	LILRB2/CD85d/ILT4 Protein, Human, Recombinant (Avi & His), Biotinylated Leukocyte Immunoglobulin-Like Receptor 2,Monocyte/M...	Human	HEK293 Cells
	Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa...
TMPJ-00538	LILRA3/CD85e Protein, Human, Recombinant (His & Avi), Biotinylated Leukocyte immunoglobulin-like receptor subfamily A member 3,...	Human	HEK293 Cells
	Leukocyte immunoglobulin-like receptor subfamily A member 3 is also known as CD85 antigen-like family member E, Immunoglobulin-like transcript 6, ILT-6, Leukocyte immunoglobulin-like receptor 4, LIR-4 and Monocyte inhibitory receptor HM43/HM31. In humans, it is encoded by the LILRA3 gene. It acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2.It is detected in B-cells, natural kil...
TMPK-01103	LILRA3/CD85e Protein, Human, Recombinant (His & Avi) HM43,LIR-4HM43e3,HM31,ILT-6,LIR4,CD85e,LILRA3,ILT6	Human	HEK293 Cells
	Human LILRA3, also known as Leukocyte Ig-like receptor 4 (LIR-4), CD85 antigen-like family member E, Immunogobulin-like transcript 6 (ILT-6) and monocyte inhibitory receptor HM43/HM31, is a 70 kD Ig superfamily member that belongs to the leukocyte receptor complex/cluster. Mature LILRA3 is 416 amino acids (aa) in length and contains four C2-type Ig-like domains. Unlike other LILR family members, LILRA3 is actively secreted.LILRA3 acts as soluble receptor for class I MHC antigens. LILRA3 binds b...