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Search Results for " ldha "

Targets Recommended: Dehydrogenase

17

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3175	LDHA-IN-4 AZ 33,AZ-33,LDHA Inhibitor,AZ33	Dehydrogenase	Metabolism
	LDHA-IN-4 (AZ33) 是乳酸脱氢酶 A 选择性抑制剂，IC50=0.5 μM，Kd=0.093 μM。
T39805	LDHA-IN-3 PSTMB,1-(phenylseleno)-4-(trifluoromethyl) benzene	Dehydrogenase	Metabolism
	LDHA-IN-3 (1-(phenylseleno)-4-(trifluoromethyl) benzene) 是一种有效的非竞争性乳酸脱氢酶(LDHA) 抑制剂，IC50值为 145.2 nM。LDHA-IN-3 是一种硒苯化合物，可用于研究癌症。
T15362	FX-11 LDHA Inhibitor FX11	Dehydrogenase	Metabolism
	FX-11 (LDHA Inhibitor FX11) 是一种有效的、选择性的和竞争性的乳酸脱氢酶 A (LDHA) 的特异性抑制剂，对LDHA 的Ki 为 8 μM。FX-11 对PKM2 (丙酮酸激酶 M2)具有激活作用。FX-11 可降低 ATP 水平，诱导氧化应激和ROS 生成，可引起细胞死亡。FX-11 在淋巴瘤和胰腺癌异种移植过程中表现出抗肿瘤活性。
T73222	LDHA-IN-5
	LDHA-IN-5为新型且有效的GO/LDHA双重抑制剂，旨在治疗原发性高草酸尿。
T60995	LDHA/PDKs-IN-2
	LDHA/PDKs-IN-2 (compound 20k) 是有效的 LDHA 和 PDKs 的双重抑制剂，IC50 值分别为 0.7 和 1.6 μM。LDHA/PDKs-IN-2 会增加耗氧量并且减少乳酸的形成。LDHA/PDKs-IN-2 显示了癌症研究的潜力，它可以减少 A549 细胞的增殖，EC50值为 15.7 μM。
T61339	LDHA/PDKs-IN-1
	LDHA/PDKs-IN-1 (compound 20e) is a highly effective dual inhibitor of PDKs and LDHA, displaying IC50 values of 0.8 μM and 0.15 μM, respectively. It significantly suppresses A549 cell proliferation (EC50 = 13.2 μM), reduces lactate formation, and enhances oxygen consumption. This compound holds great promise for cancer research [1].
T4295	(R)-GNE-140 GNE-140	Dehydrogenase	Metabolism
	(R)-GNE-140 (GNE-140) 是 LDHA 抑制剂，能够作用于 LDHA (IC50:3 nM) 和 LDHB (IC50:3 nM)。它的活性是 S 型异构体的 18 倍。
T15435	GSK2837808A	Dehydrogenase	Metabolism
	GSK2837808A 是一种选择性的乳酸脱氢酶A 抑制剂，对 hLDHA (IC50:2.6 nM) 和 hLDHB (IC50:43 nM)。
T11829	LDH-IN-1	Dehydrogenase	Metabolism
	LDH-IN-1 是新型的基于吡唑的人乳酸脱氢酶抑制剂，对于 LDHA 和 LDHB 的 IC50 分别为32和27 nM。
T19831	Sodium Oxamate 草氨酸钠,oxamate sodium,Oxamic acid sodium salt,Aminooxoacetic acid sodium salt,SO	Apoptosis; Dehydrogenase; CDK	Apoptosis; Cell Cycle/Checkpoint; Metabolism
	Sodium Oxamate (Oxamic acid sodium salt) 是一种 LDH 抑制剂，对 LDHA 特异性抑制。Sodium Oxamate 具有抗肿瘤活性，可以诱导细胞周期阻滞、细胞凋亡。
T22336	Galloflavin	Dehydrogenase	Metabolism
	Galloflavin 是乳酸脱氢酶抑制剂。用 Pyruvate 法得到的 Ki 为 5.46 µM (LDH-A) 以及15.06 µM (LDH-B)。它能够阻断 ATP 的生成和糖酵解，从而抑制癌细胞的增殖。
T24530	NHI-2 NHI 2
	NHI-2 is an inhibitor of LDHA that acts by reducing lactate production in HeLa cells.
T27421	GNE-140 racemic GNE-140,GNE 140,GNE140
	GNE-140 racemic is a potent lactate dehydrogenase (LDHA) inhibitor.
T13450L	GNE-140 racemate GNE-140 (racemate)	Others	Others
	GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.
T79204	Anticancer agent 122
	Anticanceragent 122，作为一种hLDHA抑制剂，表现出显著的抗癌活性，主要应用于抗肿瘤研究。
T79874	CHK-336
	CHK-336（Example 1）为口服活性LDHA抑制剂（IC50＜1 nM），有效抑制小鼠肝细胞产生乳酸。该化合物适用于高草酸尿症相关研究。
T81747	MS6105	PROTACs	PROTAC
	MS6105是一种具有抗癌活性的LDH蛋白水解靶向嵌合体(PROTAC)，能够依赖时间及泛素蛋白酶体系统高效地降解LDHA和LDHB。同时，MS6105也是一个点击化学试剂，含有Alkyne基团，能与含Azide基团的分子通过铜催化的叠氮-炔环加成反应(CuAAc)发生反应。

化合物

Cat.No: T3175

Synonym: AZ 33,AZ-33,LDHA Inhibitor,AZ33

Target: Dehydrogenase

Cat.No: T39805

Synonym: PSTMB,1-(phenylseleno)-4-(trifluoromethyl) benzene

Target: Dehydrogenase

Cat.No: T15362

Synonym: LDHA Inhibitor FX11

Target: Dehydrogenase

Cat.No: T73222

LDHA/PDKs-IN-2

Cat.No: T60995

LDHA/PDKs-IN-1

Cat.No: T61339

Cat.No: T4295

Synonym: GNE-140

Target: Dehydrogenase

Cat.No: T15435

Target: Dehydrogenase

Cat.No: T11829

Target: Dehydrogenase

Cat.No: T19831

Synonym: 草氨酸钠,oxamate sodium,Oxamic acid sodium salt,Aminooxoacetic acid sodium salt,SO

Target: Apoptosis, Dehydrogenase, CDK

Cat.No: T22336

Target: Dehydrogenase

Cat.No: T24530

Synonym: NHI 2

GNE-140 racemic

Cat.No: T27421

Synonym: GNE-140,GNE 140,GNE140

GNE-140 racemate

Cat.No: T13450L

Synonym: GNE-140 (racemate)

Target: Others

Anticancer agent 122

Cat.No: T79204

Cat.No: T79874

Cat.No: T81747

Target: PROTACs

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00724	LDHA Protein, Human, Recombinant (His) LDH-M,Renal Carcinoma Antigen NY-REN-59,Cell Proliferation-I...	Human	E. coli
	L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region, a central catalytic site, and at least nine utilized Lys acetylation and two Tyr phosphorylation sites. LDHA belongs to the lactate dehydrogenase family, expressed predominantly in muscle tissue. LDHA mutations have been linked to exertional myoglobinuria.
TMPY-00010	LDHA Protein, Mouse, Recombinant (His) Ldh1,lactate dehydrogenase A,Ldhm,l7R2	Mouse	E. coli
	LDHA Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 36.5 kDa and the accession number is P06151.
TMPY-04241	LDHA Protein, Rat, Recombinant (His) lactate dehydrogenase A	Rat	E. coli
	LDHA Protein, Rat, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 38.7 kDa and the accession number is B5DEN4.

重组蛋白

LDHA Protein, Human, Recombinant (His)

Cat.No: TMPJ-00724

Species: Human

Expression System: E. coli

LDHA Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00010

Species: Mouse

Expression System: E. coli

LDHA Protein, Rat, Recombinant (His)

Cat.No: TMPY-04241

Species: Rat

Expression System: E. coli

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