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Targets Recommended: Phosphatase P450 Histone Methyltransferase

2

抑制剂 & 化合物

1

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T14841 BVT948

Phosphatase; P450; Histone Methyltransferase Chromatin/Epigenetic; Metabolism
BVT948 是一种蛋白酪氨酸磷酸酶抑制剂,还可以抑制赖氨酸甲基转移酶 SETD8 (KMT5A) 和几种细胞色素 P450 (P450) 同工型。
T63705 UNC0379 TFA

UNC0379 TFA 是选择性的、底物竞争性的赖氨酸甲基转移酶 SETD8(KMT5A) 抑制剂 (IC50: 7.3 μM),对其他 15 种甲基转移酶表现出良好的选择性。

化合物

BVT948
Cat.No: T14841
Synonym:
Target: Phosphatase, P450, Histone Methyltransferase
UNC0379 TFA
Cat.No: T63705
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPY-01584 PR-Set7 Protein, Human, Recombinant

SET8,SET07,PR-Set7,SET domain containing (lysine methyltrans...

Human E. coli
KMT5A (known as PR-Set7/9, SETD8 and SET8), a member of the SET domain containing methyltransferase family specifically targeting H4K20 for methylation, has been implicated in multiple biological processes. Inhibition of KMT5A attenuated proliferation and induced apoptosis. Elevated KMT5A expression was significantly correlated with extrathyroidal extension, lymph node metastasis and advanced pathological stage of papillary thyroid cancer. KMT5A may be a novel oncogenic factor, specifically a re...

重组蛋白

PR-Set7 Protein, Human, Recombinant
Cat.No: TMPY-01584
Species: Human
Expression System: E. coli
TargetMol Loading
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