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Cat. No. | Product Name | Target | Signaling Pathways |
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T14841 |
BVT948
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Phosphatase; P450; Histone Methyltransferase | Chromatin/Epigenetic; Metabolism |
BVT948 是一种蛋白酪氨酸磷酸酶抑制剂,还可以抑制赖氨酸甲基转移酶 SETD8 (KMT5A) 和几种细胞色素 P450 (P450) 同工型。 | |||
T63705 |
UNC0379 TFA
|
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UNC0379 TFA 是选择性的、底物竞争性的赖氨酸甲基转移酶 SETD8(KMT5A) 抑制剂 (IC50: 7.3 μM),对其他 15 种甲基转移酶表现出良好的选择性。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01584 |
PR-Set7 Protein, Human, Recombinant
SET8,SET07,PR-Set7,SET domain containing (lysine methyltrans... |
Human | E. coli |
KMT5A (known as PR-Set7/9, SETD8 and SET8), a member of the SET domain containing methyltransferase family specifically targeting H4K20 for methylation, has been implicated in multiple biological processes. Inhibition of KMT5A attenuated proliferation and induced apoptosis. Elevated KMT5A expression was significantly correlated with extrathyroidal extension, lymph node metastasis and advanced pathological stage of papillary thyroid cancer. KMT5A may be a novel oncogenic factor, specifically a re... |