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Search Results for " kip1 "

Targets Recommended: Pim

5

抑制剂 & 化合物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9229	Pim-1/2 kinase inhibitor 1	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	Pim-1/2 kinase inhibitor 1 是一种具有口服活性的 Pim-1/2 激酶抑制剂。Pim-1/2 kinase inhibitor 1 能阻断 Pim 激酶磷酸化肽的能力，并且抑制4E-BP1和p27Kip1的Pim 蛋白激酶定向磷酸化。Pim-1/2 kinase inhibitor 1 可用于癌症，尤其是前列腺癌的研究。
T25738	Linichlorin A Elegin
	Linichlorin A is used as a p27(Kip1) ubiquitination inhibitor.
T71864	SJ572710
	SJ572710 is an inhibitor of the disordered protein, p27(Kip1).
T11396	GGTI-2418	Transferase	Metabolism
	GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors. GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor.
T69200	CGP74514A
	CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and...

化合物

Pim-1/2 kinase inhibitor 1

Cat.No: T9229

Target: Pim

Cat.No: T25738

Synonym: Elegin

Cat.No: T71864

Cat.No: T11396

Target: Transferase

Cat.No: T69200

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00972	CDKN1B Protein, Human, Recombinant (His) KIP1,CDKN1B,Cyclin-Dependent Kina...	Human	E. coli
	Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an ...

重组蛋白

CDKN1B Protein, Human, Recombinant (His)

Cat.No: TMPJ-00972

Species: Human

Expression System: E. coli

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