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抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T15660	KHK-IN-1 KHK-IN-8,Ketohexokinase inhibitor 8	Others	Others
	KHK-IN-1 (KHK-IN-8) 是一种选择性的、细胞膜渗透性的己酮糖激酶 (KHK) 抑制剂 (IC50=12 nM; F=34%)。KHK-IN-1 抑制 HepG2 细胞裂解液中 F1P 生成，IC50为400 nM。KHK-IN-1 可用于研究糖尿病和肥胖症。
T11757	KHK-IN-2	Others	Others
	KHK-IN-2是一种选择性的酮基己酸酶抑制剂，IC50值为0.45μM。
T76779	Brodalumab LP 0160,KHK-4827,AMG-827	IL Receptor	Immunology/Inflammation
	Brodalumab (AMG 827) 是一种人源靶向白介素 17 受体 (IL-17R) IgG2 的单克隆抗体，常作为免疫抑制剂来治疗银屑病和牛皮藓。
T15261	Evocalcet 伊万卡赛,KHK7580	CaSR	GPCR/G Protein
	Evocalcet (KHK7580) 对钙敏感受体具有激活作用。
T15659	KHK-IN-1 hydrochloride	Others	Others
	KHK-IN-1 hydrochloride is a potent inhibitor of ketohexokinase (KHK) (IC50: 12 nM). In the ATP-binding region of KHK, KHK-IN-1 hydrochloride interacts with Asp-27B.
T81982	KHK-IN-4
	KHK-IN-4（compound 14）是一种针对酮己糖激酶（KHK）的高效抑制剂，适用于果糖代谢疾病的研究。
T78333	Rocatinlimab AMG 451,KHK4083
	Rocatinlimab（AMG 451）（KHK4083）为全人源非岩藻糖化IgG1抗OX40单克隆抗体，旨在用于特应性皮炎（AD）研究。
T15654	Ketohexokinase inhibitor 1 PF-06835919	Others	Others
	Ketohexokinase inhibitor 1 是一种酮己糖激酶抑制剂（对 KHK-C 和 KHK-A 的 IC50：分别为 8.4 nM 和 66 nM）。

化合物

KHK-IN-1

Cat.No: T15660

Synonym: KHK-IN-8,Ketohexokinase inhibitor 8

Synonym: LP 0160,KHK-4827,AMG-827

Target: IL Receptor

Evocalcet

Cat.No: T15261

Synonym: 伊万卡赛,KHK7580

Target: CaSR

KHK-IN-1 hydrochloride

Synonym: AMG 451,KHK4083

Target:

Ketohexokinase inhibitor 1

Cat.No: T15654

Synonym: PF-06835919

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00479	KHK Protein, Human, Recombinant (His) KHK,Hepatic fructokinase,Ketohexokinase	Human	HEK293 Cells
	Ketohexokinase, also known as Hepatic fructokinase, is a member of the carbohydrate kinase PfkB family. It exits as a homodimer and most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adrenal, muscle, brain and eye.This enzyme catalyzes conversion of fructose to fructose-1-phosphate. It is the first enzyme with a specialized pathway that catabolizes dietary fructose. Defects in KHK are the cause of fructosuria.
TMPH-01585	Ketohexokinase/KHK Protein, Human, Recombinant (GST)	Human	E. coli
	Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. Ketohexokinase/KHK Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 59.7 kDa and the accession number is P50053.
TMPH-02747	Ketohexokinase/KHK Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Ketohexokinase/KHK Protein, Mouse, Recombinant (His) is expressed in E. coli.