Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1752 |
NS6180
|
Potassium Channel | Membrane transporter/Ion channel |
NS6180是一种高效的KCa3.1离子通道选择性抑制剂,IC50值9nM。NS6180阻止T 细胞活化和炎症反应。 | |||
T6186 |
TRAM-34
Triarylmethane-34,TRAM 34 |
Potassium Channel; IκB/IKK | Membrane transporter/Ion channel; NF-κB |
TRAM-34 (Triarylmethane-34) 是一种高选择性的钙激活 K+通道 (IKCa1)阻断剂,Kd 值为 20 nM。 | |||
T3528 |
Senicapoc
塞尼卡泊,ICA-17043 |
Potassium Channel | Membrane transporter/Ion channel |
Senicapoc (ICA-17043) 是有效的,选择性的Gardos 通道 (Ca2+激活的 K+通道;KCa3.1) 阻断剂,IC50为 11 nM。Senicapoc 阻断人红细胞的 Ca2+诱导的铷通量,IC50为 11 nM, 抑制红细胞脱水的IC50为 30 nM。 | |||
T39283 |
OSK-1
|
||
OSK-1 is a potent potassium channel blocker belonging to the α-KTx3 toxins. It exhibits IC50 values of 0.6 nM, 5.4 nM, and 0.014 nM for Kv1.1, Kv1.2, and Kv1.3 channels, respectively. Additionally, OSK-1 acts as a moderate blocker of the calcium-activated KCa3.1 channel, with an IC50 of 225 nM. Consequently, OSK-1 finds application as an immunosuppressive drug. | |||
TP2007 |
Lei-Dab7
Lei-Dab 7 |
||
High affinity, selective KCa2.2 (SK2) channel blocker (Kd = 3.8 nM). Exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, IK, Kv and Kir2.1. Increases theta-burst responses and increases LTP in rat hippocampal slices in vitro. Convulsive |