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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
TQ0319	Ripasudil K-115,瑞舒地尔盐酸二水合物,Ripasudil hydrochloride dihydrate	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Ripasudil (Ripasudil hydrochloride dihydrate) 是一种 ROCK 特异性抑制剂，能够抑制 ROCK1和 ROCK2的活性，IC50值分别为 51 和 19 nM。
T7492	Ripasudil free base K-115 (free base)	ROCK; Antibacterial	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Microbiology/Virology; Stem Cells
	Ripasudil free base (K-115 (free base)) 是一种ROCK 特异性抑制剂，能够抑制ROCK1和ROCK2的活性，IC50值分别为 51 和 19 nM。
T21617	MG-115 Z-LL-Nva-CHO	Proteasome	Proteases/Proteasome; Ubiquitination
	MG-115 (Z-LL-Nva-CHO) 是一种有效且可逆的蛋白酶体抑制剂，对20S 和26S 蛋白酶体的 Ki 值分别为 21 nM 和 35 nM。MG-115 特异性抑制蛋白酶体的胰凝乳蛋白酶样活性，诱导 p53 依赖性细胞凋亡。
T24873	TGX-115 TGX 115	PI3K	PI3K/Akt/mTOR signaling
	TGX-115是一种细胞渗透性和有效的PI 3-K 异构体p110β/p110δ抑制剂(对p110β IC50值为 0.13 μM, 对p110δ值为0.63 μM），是一种调节血小板粘附过程的酶，可抑制磷酸肌苷（PI）3-激酶，可用来治疗冠状动脉闭塞、中风、急性冠状动脉综合征、急性心肌梗塞、血管再狭窄、动脉硬化和不稳定心绞痛等心血管疾病。
T36100	K-TMZ
	K-TMZ is a DNA alkylating agent. It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking (IC50s = 18-44 μM) or expressing O6-methylguanine DNA methyltransferase (MGMT; IC50s = 115-240 μM). K-TMZ can cross the blood-brain barrier and increases survival in a Br23c mouse xenograft model of GBM when administered at a dose of 14.9 mg/kg.

化合物

Ripasudil

Cat.No: TQ0319

Synonym: K-115,瑞舒地尔盐酸二水合物,Ripasudil hydrochloride dihydrate

Target: ROCK

Ripasudil free base

Cat.No: T7492

Synonym: K-115 (free base)

Target: ROCK, Antibacterial

MG-115

Cat.No: T21617

Synonym: Z-LL-Nva-CHO

Target: Proteasome

TGX-115

Cat.No: T24873

Synonym: TGX 115

Cat. No.	Product Name	Target	Signaling Pathways
T37609	(rel)-Asperparaline A
	Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces...