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Cat. No.	Product Name	Target	Signaling Pathways
T0972	Isoniazid INH,异烟肼,Isonicotinic acid hydrazide,Isonicotinic hydrazide	Mitophagy; Dehydrogenase; CAT; Antibacterial; Autophagy	Autophagy; Metabolism; Microbiology/Virology; oxidation-reduction
	Isoniazid (Isonicotinic hydrazide) 是一种必须被细菌过氧化氢酶 KatG 激活的前药，具有抗菌活性。它对快速分裂的分枝杆菌具有杀菌作用。
T32221	Isoniazid pyruvate NSC-97221,BRN 0185611,NSC97221,NSC 97221,L 1011
	Isoniazid pyruvate is a metabolite of isoniazid. Isoniazid (Laniazid, Nydrazid), also known as isonicotinylhydrazine (INH), is an organic compound that is the first-line medication in prevention and treatment of tuberculosis.
T22782	FGIN-1-27	Others	Others
	FGIN 1-27 是一种吲哚乙酰胺，是外周苯二氮卓受体的特异性的配体，Ki 为 5.0 nM。FGIN 1-27 可以透过血脑屏障。FGIN 1-27对异烟肼引起的抽搐发作具有抑制作用。
T10513	Benzothiohydrazide	Antibacterial	Microbiology/Virology
	Benzothiohydrazide 是异烟肼的类似物，具有抗结核活性，可用于分离真菌和细菌。
T36050	Linoleoyl-L-carnitine (chloride)
	Linoleoyl-L-carnitine is a naturally occurring long-chain acylcarnitine. Hepatic levels of linoleoyl-L-carnitine are increased following high-dose (200 mg/kg) administration of isoniazid in mice.
T37070	Pyridomycin
	Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid. It inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 μg/ml).
T79561	Mtb-IN-5
	Mtb-IN-5（化合物(-)17j）是一种异恶唑类化合物，对结核分枝杆菌(Mtb)具有活性。它能够抑制宿主巨噬细胞内Mtb的呼吸及生物膜生长，且能够增强异烟肼(INH)对耐INH Mtb突变株的抑制效果。
T79559	Mtb-IN-4
	Mtb-IN-4（化合物17h）是一种异恶唑类化合物，显示出针对结核分枝杆菌（Mtb）的抗活性，其IC50值为0.70 μM。它能阻断巨噬细胞内Mtb的呼吸和生物膜形成，并可以增强抗生素异烟肼（INH）对耐INH Mtb突变体的抑制效果。
T38073	Thiocarlide Isoxyl
	Thiocarlide (isoxyl) is a thiourea derivative that was used in the 1960s to successfully treat tuberculosis (TB). It has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis in the range of 1-10 &#181g/ml. [1] [2] At concentrations of 10 &#181M, isoxyl inhibits the synthesis of M. bovis during six hours of exposure which is similar to isoniazid (INH) and ethionamide (ETH), two other predominant anti-tuberculosis drug...
T37880	OPC-167832
	OPC-167832 is a potent and orally active dprE1 Inhibitor with an IC50 of 0.258 μM. OPC-167832 has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis[1]. OPC-167832 exhibits very low MICs against laboratory strains of M. tuberculosis H37Rv (MIC: 0.0005 μg/ml) and Kurono (MIC: 0.0005 μg/ml) and strains with monoresistance to rifampin (RIF), isoniazid (INH), ethambutol (EMB), streptomycin (STR), and pyrazinamide (PZA) (MIC: 0.00024-0.001 ...
T35426	β-Defensin-1 (human) (trifluoroacetate salt)
	β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth ofB. adolescentis,L. acidophilus,B. breve,B. vulgatus,L. fermentum,B. longum, andS. thermophilusin an antimicrobial radial diffusion assay.2β-Defensin-1 also inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius, and of susceptibleM. tuberculosisH37Rv but no...

化合物

Isoniazid

Cat.No: T0972

Synonym: INH,异烟肼,Isonicotinic acid hydrazide,Isonicotinic hydrazide

Target: Mitophagy, Dehydrogenase, CAT, Antibacterial, Autophagy

Isoniazid pyruvate

Cat.No: T32221

Synonym: NSC-97221,BRN 0185611,NSC97221,NSC 97221,L 1011

Target: Antibacterial

Linoleoyl-L-carnitine (chloride)

β-Defensin-1 (human) (trifluoroacetate salt)

Cat.No: T35426

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
Fr13756	Isonicotinic acid	Endogenous Metabolite; Drug Metabolite	Metabolism
	Isonicotinic acid 是 Isoniazid 的代谢产物。Isoniazid 通过肼解转化为 Isonicotinic acid。 Isoniazid 向 Isonicotinic acid 的生物转化可以通过细胞色素 P450 酶催化。

天然产物

Isonicotinic acid

Cat.No: Fr13756

Synonym:

Target: Endogenous Metabolite, Drug Metabolite

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