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Search Results for " interleukin-19 "

Targets Recommended: Interleukin

6

抑制剂 & 化合物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9911	Tocilizumab	Interleukin	Immunology/Inflammation
	Tocilizumab 是抗人白细胞介素-6 受体 (IL-6R) 的中和抗体，能够阻碍 IL-6 与 IL-6R 的结合，进而抑制经典和反式信号。它可用于研究类风湿性关节炎，对重症 COVID-19 冠状病毒病方面的研究具有显著效果。
T36534	SDZ 224-015 SDZ 224015	IL Receptor; Caspase	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	SDZ 224-015 是白细胞介素-1β（IL-1β）转化酶和 Caspase-1 的口服活性抑制剂。SDZ 224-015 具有抗 COVID-19 和抗炎活性，可减少角叉菜胶诱导的大鼠爪子水肿。
T63315	IRAK4-IN-19
	IRAK4-IN-19 是白介素 1 受体相关激酶 4 (IRAK4) 的有效抑制剂 (IC50: 4.3 nM)。IRAK4-IN-19 能够阻碍 THP 和 DC 细胞中 LPS 诱导的 IL23 产生，抑制关节炎模型大鼠的关节炎发展。IRAK4-IN-19 能够用于研究关节炎疾病。
T73372	GNE-2256
	GNE-2256 (molecule 19) 是一种具有口服活性的IRAK4(白介素 1 受体关联激酶 4) 抑制剂 (IRAK4Ki=1.4 nM ; IL-6IC50=190 nM)。
T39106	BMSpep-57
	BMSpep-57, a potent macrocyclic peptide inhibitor, competitively disrupts the PD-1/PD-L1 interaction, demonstrating a significant inhibitory concentration (IC50) of 7.68 nM. It exhibits binding affinity towards PD-L1 with dissociation constants (Kd) of 19 nM and 19.88 nM in MicroScale Thermophoresis (MST) and Surface Plasmon Resonance (SPR) assays, respectively. This compound enhances T cell functionality by promoting Interleukin-2 (IL-2) production within Peripheral Blood Mononuclear Cells (PBM...
T76675	Clazakizumab
	Clazakizumab是一种具有高亲和力和特异性的单克隆抗体，针对IL-6(白细胞介素-6)细胞因子。它可能对抑制COVID-19中因SARS-CoV-2引起的细胞因子反应有帮助。此外，Clazakizumab也被用于研究银屑病关节炎(PsA)和肾抗体介导的排斥反应。

化合物

Cat.No: T9911

Target: Interleukin

Cat.No: T36534

Synonym: SDZ 224015

Target: IL Receptor, Caspase

Cat.No: T63315

Cat.No: T73372

Cat.No: T39106

Cat.No: T76675

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00841	IL-13RA2 Protein, Human, Recombinant (His) CT19,interleukin 13 receptor, alpha 2,CD21...	Human	HEK293 Cells
	IL-13RA2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is Q14627.
TMPY-04874	IL-23 P19/IL23A Protein, Human, Recombinant (hFc) IL-23A,IL-23,interleukin 23, alpha subunit p19<...	Human	HEK293 Cells
	IL-23 P19/IL23A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.4 kDa and the accession number is Q9NPF7.
TMPY-00493	IL-19 Protein, Human, Recombinant (His) interleukin 19,Interleukin-19...	Human	Baculovirus Insect Cells
	The molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection. Interleukin (IL) 19, IL-20, and IL-24 belong to the IL-10 cytokine family and have been identified to play a role in the regulation of epidermal functions and inflammation. The expression of IL19 in biopsies of patients with active ulcerative colitis was increased compared with patients with quiescent ulcerative colitis and that colitis was attenuated in IL-19-deficient mice. The disruption of the e...
TMPK-01229	IL-19 Protein, Human, Recombinant (hFc) NG.1,IL-10C,Interleukin-19,白介素,白细胞介素,MDA1,...	Human	HEK293 Cells
	Interleukin-19 (IL-19) has been shown to be involved in coronary artery diseases and atherosclerosis, while its expression in myocardial infarction is poorly understood. In this study, the dynamic increase in circulating IL-19 in acute ST-segment elevation myocardial infarction (STEMI) patients was detected.IL-19 is correlated with the severity of acute myocardial infarction, which may be a new idea for the clinical treatment of myocardial infarction.
TMPY-00842	IL-13RA2 Protein, Human, Recombinant (His & hFc) CT19,IL13BP,interleukin 13 receptor, alpha...	Human	HEK293 Cells
	IL-13RA2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 65 kDa and the accession number is Q14627.
TMPY-05334	IL-13RA2 Protein, Human, Recombinant (His), Biotinylated CT19,IL-13R,IL13BP,interleukin 13 receptor...	Human	HEK293 Cells
	IL-13RA2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is Q14627.
TMPY-04987	IL-23 P19/IL23A Protein, Human, Recombinant (mFc) IL-23,interleukin 23, alpha subunit p19,SG...	Human	HEK293 Cells
	IL-23 P19/IL23A Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 45 kDa and the accession number is Q9NPF7.
TMPK-01169	IL-23 P19/IL23A Protein, Mouse, Recombinant (His & Avi), Biotinylated Interleukin-23 subunit α,Interleukin-23 su...	Mouse	HEK293 Cells
	The heterodimeric cytokine interleukin-23 (IL-23 or IL23A/IL12B) is produced by dendritic cells and macrophages and promotes the proinflammatory and regenerative activities of T helper 17 (Th17) and innate lymphoid cells. A recent study has reported that IL-23 is also secreted by lung adenoma cells and generates an inflammatory and immune-suppressed stroma.
TMPJ-00909	IL-1RA Protein, Mouse, Recombinant IL-1RN,IRAP,Interleukin-1 Receptor Antagonist Prote...	Mouse	E. coli
	Interleukin-1 receptor antagonist protein (Il1rn), also known as IL-1ra, IRAP or IL1 inhibitor, is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. The mouse Il1rn gene encodes a 178 amino acids (aa) protein with a 26 aa signal peptide. Mouse Il1rn protein shares 26% and 19% identity with its homologues IL-1 beta and I...

重组蛋白

IL-13RA2 Protein, Human, Recombinant (His)

Cat.No: TMPY-00841

Species: Human

Expression System: HEK293 Cells

IL-23 P19/IL23A Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04874

Species: Human

Expression System: HEK293 Cells

IL-19 Protein, Human, Recombinant (His)

Cat.No: TMPY-00493

Species: Human

Expression System: Baculovirus Insect Cells

IL-19 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01229

Species: Human

Expression System: HEK293 Cells

IL-13RA2 Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-00842

Species: Human

Expression System: HEK293 Cells

IL-13RA2 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05334

Species: Human

Expression System: HEK293 Cells

IL-23 P19/IL23A Protein, Human, Recombinant (mFc)

Cat.No: TMPY-04987

Species: Human

Expression System: HEK293 Cells

IL-23 P19/IL23A Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01169

Species: Mouse

Expression System: HEK293 Cells

IL-1RA Protein, Mouse, Recombinant

Cat.No: TMPJ-00909

Species: Mouse

Expression System: E. coli

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