Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1055 |
Ifosfamide
NSC109724,Isophosphamide,异环磷酰胺 |
DNA Alkylator/Crosslinker; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Ifosfamide (NSC-109724) 是一种烷化剂,具有抗肿瘤活性。它烷基化并形成 DNA 交联,从而防止 DNA 链分离和 DNA 复制。它是一种前药,必须通过肝微粒体酶的羟基化来激活。 | |||
T25723 |
L-Ifosfamide
(+)-Ifosfamide |
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L-Ifosfamide is nitrogen mustard, a chemotherapeutic antineoplastic, and more precisely an alkylating agent structural analog of cyclophosphamide with respect to which presents some differences regard to the antitumor activity and spectrum. | |||
T4350 |
Palifosfamide
ZIO-201,Isophosphamide mustard,帕利伐米,Isophosphoramide mustard |
DNA Alkylator/Crosslinker; DNA Alkylation; Drug Metabolite | DNA Damage/DNA Repair; Metabolism |
Palifosfamide (Isophosphamide mustard) 是一种新 DNA 烷化剂,是异环磷酰胺的活性代谢物,。它在体外肉瘤细胞系中具有广泛的活性,具有抗癌活性。 | |||
T29851 |
Aldoifosfamide
UNII-S1JX147O5E,Mitoxana,Ifex |
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Aldoifosfamide is a metabolite of ifosfamide. Ifosfamide (also marketed as Mitoxana and Ifex) is a nitrogen mustard alkylating agent used in the treatment of cancer. It is sometimes abbreviated 'IFO''. | |||
T71500 |
Palifosfamide tromethamine
IPM tromethamine,Isophosphoramide mustard tromethamine,ZIO-201 tromethamine,Isophosphoramide mustard tromethamine ; IPM tromethamine ; ZIO-201 tromethamine |
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Palifosfamide (tromethamine) 是一种具有潜在抗肿瘤活性的合成烷基化剂。作为异环磷酰胺 (ifosfamide) 稳定的活性代谢物,Palifosfamide (tromethamine) 通过GC 碱基对不可逆地烷基化和交联DNA,导致了DNA 复制的抑制,并导致细胞死亡。与异环磷酰胺相比,Palifosfamide (tromethamine)的毒性较小。 | |||
T83317 |
4-Hydroperoxyifosfamide
|
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4-Hydroperoxyifosfamide是一种能穿透血脑屏障的抗癌化合物。 | |||
T1414 |
Sodium 2-mercaptoethanesulfonate
Mitexan,美司那,美司钠,Uromitexan,Mesna,Mesnum,Mesnex |
Others | Others |
Sodium 2-mercaptoethanesulfonate (Uromitexan) 是一种抗氧化剂,具有细胞保护作用。它可用于减轻由环磷酰胺引起的出血性膀胱炎。它广泛用作抗化学疗法毒性的全身保护剂。 |