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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1186L	Ifenprodil RC 61-91,RC-61-91,RC61-91,艾芬地尔,RC 6191	Adrenergic Receptor; NMDAR	GPCR/G Protein; Neuroscience
	Ifenprodil (RC61-91) 是 NMDA 受体抑制剂，特别是 GluN1(甘氨酸结合 NMDA 受体亚基 1)和 GluN2B(谷氨酸结合 NMDA 受体亚基 2)亚基的抑制剂。此外，它抑制 GIRK 通道并与 α1 肾上腺素能、血清素和 sigma 受体相互作用。
T41182	Ifenprodil hemitartrate
	Ifenprodil hemitartrate is a NMDA receptor antagonist, acting at the polyamine site. Also anα-adrenergic vasodilator.σ2ligand displaying about 3-fold selectivity overσ1sites.
T11629	Ifenprodil glucuronide	Others	Others
	Ifenprodil glucuronide, a derivative of Ifenprodil, is a vasodilator and an inhibitor of platelet aggregation. In contrast to Ifenprodil, Ifenprodil glucuronide does not affect platelet aggregation nor arterial contraction.
T23457	threo Ifenprodil hemitartrate	Others	Others
	σ receptor agonist and NR2B subunit-selective NMDA receptor antagonist
T8920	Sepimostat	iGluR	Membrane transporter/Ion channel; Neuroscience
	Sepimostat 通过 NR2B 亚基的 Ifenprodil 结合位点的 NR2B N-甲基-D-天冬氨酸受体拮抗作用表现出神经保护活性。它抑制 Ifenprodil 结合的 Ki 值为27.7 µM。
T37096	Sepimostat dimethanesulfonate
	Sepimostat dimethanesulfonate (FUT-187) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki value of 27.7 μM[1]. Sepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect[1]. ...
T71290	EVT-101 HCl
	EVT-101 is a GluN2B antagonist, binding at the same GluN1/GluN2B dimer interface as ifenprodil but adopting a remarkably different binding mode involving a distinct subcavity and receptor interactions.
T70049	Ro 04-5595 free base
	Ro 04-5595 is a selective antagonist of NMDA receptors NR2B subunits. Ro 04-5595 had an EC 50 of 186 ± 32 nmol/L. Ro 04-5595 was predicted to bind the EVT-101 binding site, not the ifenprodil-binding site. Specific binding, defined with a new NR2B-specific antagonist Ro 04-5595 at 10 microM was fully inhibited by several compounds with the following rank order of affinities--Ro 25-6981 > CP-101,606 > Ro 04-5595 = ifenprodil >> eliprodil > haloperidol > spermine > spermidine > MgCl2 > CaCl2--and...

化合物

Ifenprodil

Cat.No: T1186L

Synonym: RC 61-91,RC-61-91,RC61-91,艾芬地尔,RC 6191

Target: Adrenergic Receptor, NMDAR

Ifenprodil hemitartrate

Cat.No: T41182

Synonym:

Target:

Ifenprodil glucuronide

Cat.No: T11629

Synonym:

Target: Others

threo Ifenprodil hemitartrate

Sepimostat dimethanesulfonate

Cat. No.	Product Name	Target	Signaling Pathways
T1186	Ifenprodil Tartrate	Potassium Channel; NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Ifenprodil tartrate 是典型的非竞争性 NMDA 受体拮抗剂，抑制 GIRK (Kir3)，通过基底 GIRK 活性减少内向电流，有用做脑血管舒张试剂的潜力。它对 NR1A/NR2B 受体亲和力是 NR1A/NR2A 受体的 400 倍。
T22583	Arcaine sulfate	NMDAR	Neuroscience
	Arcaine sulfate 是一种多胺，是 N-甲基-d-天冬氨酸 (NMDA) 受体多胺结合位点的拮抗剂。 Arcaine 是一种胍丁胺类似物，与 ifenprodil 一起，可能有可能用于治疗癫痫疾病。