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Cat. No. | Product Name | Target | Signaling Pathways |
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T40359 |
Thio-ITP
6-Thio-ITP,Thio-ITP,6-Mercaptopurine-riboside-5'-triphosphate,6-Thioinosine 5′-triphosphate |
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Thio-ITP, also known as 6-Thioinosine 5'-triphosphate, is a competitive inhibitor of RNA polymerase activity. It exhibits a strong apparent affinity towards the polymerases, with Ki values of 40.9 μM for RNA polymerase I and 38.0 μM for RNA polymerase II. | |||
T70691 |
ITP-2
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ITP-2 is a selective activator of hERG channels. ITP-2 causes large depolarizing shifts in the midpoint of voltage-dependent inactivation and hyperpolarizing shifts in the voltage-dependence of activation. | |||
T70689 |
MEN-10354
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MEN-10354 is a less potent and less selective NK-2 tachykinin receptor antagonist compared to the linear analog, R 396. | |||
T32088 |
Sovleplenib
HMPL 523,HMPL523,HMPL-523 |
Syk | Angiogenesis; Tyrosine Kinase/Adaptors |
Sovleplenib (HMPL523) 是一种可口服且具有选择性和高效性的脾酪氨酸激酶 SYK 抑制剂,IC50 为 25 nM。Sovleplenib 具有抗肿瘤活性,可用于免疫性血小板减少症(ITP)的研究。 | |||
T82893 |
Bevifimod
PRTX-100 |
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Bevifimod (PRTX-100),一种高度纯化的葡萄球菌蛋白A (SpA),主要用于特发性血小板减少性紫癜(ITP)的研究。 | |||
T77084 | Mezagitamab | ||
Mezagitamab (TAK-079) 是一种 IgG1λ 类型的抗CD38单克隆抗体。其通过促进抗体和补体依赖性的细胞毒性,来耗尽表达CD38的肿瘤细胞,显示出在复发/难治性多发性骨髓瘤 (RRMM) 及原发性血小板减少性紫癜 (ITP) 等疾病中的治疗潜力。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T4897 |
Inosine-5'-triphosphate trisodium salt
ITP,肌苷-5'-三磷酸三钠盐,三磷酸肌苷三钠盐,Inosine 5'-triphosphate trisodium salt |
Others; Endogenous Metabolite | Metabolism; Others |
Inosine-5'-triphosphate trisodium salt (ITP) 是三磷酸核苷,能够作为 ATPases 和 GTPases 的底物。 |