Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11690 | ITK inhibitor 2 | JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
ITK inhibitor 2 is a interleukin-2-inducible T-cell kinase (ITK) inhibitor , with an IC50 of 2 nM. | |||
T35569 |
CTA 056
|
Apoptosis | Apoptosis |
CTA 056 是白细胞介素-2 诱导的 T 细胞激酶(ITK)抑制剂,抑制小鼠 MOLT-4 异种移植肿瘤的生长,诱导 Jurkat 细胞凋亡,可用于研究自身免疫性疾病和T细胞恶性肿瘤。 | |||
T4263 |
BAY 61-3606
2-[[7-(3,4-二甲氧基苯基)咪唑并[1,2-C]嘧啶-5-基]氨基]-3-吡啶甲酰胺,Syk inhibitor IV |
Apoptosis; Syk | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
BAY 61-3606 (Syk inhibitor IV) 是一种具有口服活性的,ATP 竞争性的可逆选择性Syk 抑制剂。它作用于乳腺癌细胞,通过下调 Mcl-1 促进 TRAIL 诱导的细胞凋亡。它降低神经母细胞瘤细胞中的 ERK1/2 和 Akt 磷酸化,也降低 K-rn 细胞裂解物中 Syk 磷酸化。 | |||
T16493 |
PF-06465469
|
Others | Others |
PF-06465469 is a covalent ITK inhibitor(IC50: 2 nM). | |||
T63229 |
ITK inhibitor 6
|
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ITK inhibitor 6 是选择性的、有效的 ITK 抑制剂,能够作用于 ITK (IC50: 4 nM)、BTK (IC50: 133 nM)、JAK3 (IC50: 320 nM)、EGFR (IC50: 2360 nM)、LCK (IC50: 155 nM)。ITK inhibitor 6 对 PLCγ1 和 ERK1/2 的磷酸化具有抑制作用,表现出抗增殖效果。 | |||
T40294 |
ITK/TRKA-IN-1
|
||
ITK/TRKA-IN-1 is a chemical compound that functions as a dual inhibitor of IL-2-inducible T-cell kinase (ITK) and tropomyosin receptor kinase A (TRKA). With an IC50 value of 1.0 nM, it effectively inhibits the activity of ITK, while demonstrating a remarkable 96% inhibition of TRKA. | |||
T16578 |
PRN694
|
Others | Others |
PRN694 shows extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo. PRN694 is an irreversible, highly selective, and effective covalent interleukin-2-inducible T-cell kinase (ITK) and resting ly | |||
T37604 | ITK inhibitor | ||
Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine receptor CXCR4, and FcepsilonR-mediated signaling pathways. ITK inhibitors can be used for the treatment of inflammation and immune-mediated disorders. ITK inhibitor (N-[5-[[3-[(4-Acetylpiperazin-1-yl)carbonyl]-4-methyl-6-methoxy-phenyl]thio]thiazol-2-yl]-4-(N-1,2-dimethylpropylaminome... |