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14

抑制剂 & 化合物

1

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Cat. No.	Product Name	Target	Signaling Pathways
T27617	Inz-1	P450	Metabolism
	Inz-1 是一种有效的真菌特异性线粒体细胞色素 bc1 抑制剂，对酵母和人类的 IC50 分别为 8.092 和 45.320 μM。 Inz-1 可逆转氟康唑或其他三唑类抗真菌药对致病性真菌白色念珠菌的耐药性。
T1887	Inauhzin INZ	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Inauhzin (INZ) 是一种新型小分子，通过抑制 SIRT1 活性有效地重新激活 p53，促进人 Y 细胞的 p53 依赖性凋亡，在 A549 细胞中的IC50为3 uM。
T27618	Inz-4
	Inz-4 is a fungal-selective inhibitor of mitochondrial cytochrome bc1.
T15587	Inz-5	Others	Others
	Inz-5 is a fungal-selective inhibitor of mitochondrial cytochrome bc1. Inz-5 impairs fungal virulence. It also prevents the evolution of drug resistance.
T38144	Elinzanetant	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Elizanetant 是有效的神经激肽受体拮抗剂，在精神分裂症研究中有价值。
T25742	Linzagolix choline	GNRH Receptor	GPCR/G Protein
	Linzagolix choline 是一种可口服的非肽类的促性腺激素释放激素（GnRH）拮抗剂。可用于研究子宫肌瘤和子宫内膜异位症相关疼痛。
T27837	Linzagolix	GNRH Receptor	GPCR/G Protein
	Linzagolix 是一种口服有活性的非多肽GnRH 拮抗剂。可用于研究子宫肌瘤、子宫腺肌症、子宫内膜异位症。
T62304	Minzasolmin (R)-NPT200-11,UCB0599,DLX-313	Others	Others
	Minzasolmin（DLX-313）是一种 α-突触核蛋白错误折叠抑制剂，可用于研究帕金森疾病。
T0142	Brinzolamide 布林佐胺,AL-4862	Carbonic Anhydrase	Metabolism
	Brinzolamide (AL-4862) 是一种碳酸酐酶(carbonic anhydrase)II 抑制剂(IC50:3.19 nM)。
T37403	O-desmethyl Brinzolamide (hydrochloride)
	O-desmethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1,2It inhibits CAII and CAIV (IC50s = 0.136 and 165 nM, respectively).1 1.Huang, Q., Rui, E.Y., Cobbs, M., et al.Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressureJ. Med. Chem.58(6)2821-2833(2015) 2.Lo Faro, A.F., Tini, A., Gottardi, M., et al.Development and validation of a fast ultra-high-performance liquid chromatography tand...
T35713	N-desethyl Brinzolamide (oxalate)
	N-desethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1It inhibits CAII and CAIV activities (IC50s = 1.28 and 128 nM, respectively). 1.Kim, C.-Y., Whittington, D.A., Chang, J.S., et al.Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IVJ. Med. Chem.45(4)888-893(2002)
T76906	Anrukinzumab
	Anrukinzumab (IMA-638)，一种针对人IL-13的人源化单克隆抗体，展示了在食蟹猕猴肺部炎症模型中显著的疗效。Anrukinzumab 目前被用于溃疡性结肠炎（UC）和哮喘的研究中。
T64241	Brinzolamide hydrochloride
	Brinzolamide (AL-4862) hydrochloride 是一种碳酸酐酶 II（carbonic anhydrase II）的选择性抑制剂 (IC50: 3.2 nM)。Brinzolamide hydrochloride 能够抑制睫状体 CA-II，减少房水分泌，进而降低眼压 (IOP)。Brinzolamide hydrochloride 能够用于研究青光眼疾病。
T31240	Deacetoxyvinzolidine KAR-2,KAR2,KAR 2
	Deacetoxyvinzolidine is a bioactive agent.

化合物

Cat.No: T27617

Target: P450

Cat.No: T1887

Synonym: INZ

Target: Sirtuin

Cat.No: T27618

Cat.No: T15587

Target: Others

Cat.No: T38144

Target: Neurokinin receptor

Linzagolix choline

Cat.No: T25742

Target: GNRH Receptor

Cat.No: T27837

Target: GNRH Receptor

Cat.No: T62304

Synonym: (R)-NPT200-11,UCB0599,DLX-313

Target: Others

Cat.No: T0142

Synonym: 布林佐胺,AL-4862

Target: Carbonic Anhydrase

O-desmethyl Brinzolamide (hydrochloride)

Cat.No: T37403

N-desethyl Brinzolamide (oxalate)

Cat.No: T35713

Cat.No: T76906

Brinzolamide hydrochloride

Cat.No: T64241

Deacetoxyvinzolidine

Cat.No: T31240

Synonym: KAR-2,KAR2,KAR 2

Cat. No.	Product Name	Target	Signaling Pathways
T35761	Carviolin
	Carviolin is an anthraquinone fungal metabolite that has been found inZ. longicaudatawith immunosuppressive and antitrypanosomal activities.1,2It inhibits LPS- or concanavalin A-induced proliferation of mouse splenocytes (IC50s = 4 and 4.5 μg/ml, respectively).1Carviolin is active againstT. b. brucei(MIC = 41.66 μM).2 1.Fujimoto, H., Nakamura, E., Okuyama, E., et al.Six immunosuppressive features from an ascomycete, Zopfiella longicaudata, found in a screening study monitored by immunomodulatory...

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Cat.No: T35761

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