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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0097 |
MRT67307
MRT67307 HCl |
IκB/IKK; Autophagy | Autophagy; NF-κB |
MRT67307 是一种IKKε和TBK-1的双抑制剂,IC50分别为 160 和 19 nM。它抑制细胞自噬,也可抑制ULK1和ULK2,IC50分别为 45 和 38 nM。 | |||
T23028 |
MRT67307 HCl (1190378-57-4 free base)
MRT67307 HCl |
Others | Others |
MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it is a salt inducible kinase (SIK) inhibitor with IC50 value of 250, 67 and 430nM for SIK1, SIK2 and SIK3, respectively.<br />SIKs prevent the formation of regulatory macrophages and their inhibition induces increasing in some markers of regulatory macrophages, such as IL-10 and oth... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00853 |
IL-1RA Protein, Human, Recombinant
DIRA,IL1RA,interleukin <... |
Human | E. coli |
IL-1RA Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is P18510-1. | |||
TMPY-00852 |
IL-1RA Protein, Human, Recombinant (hFc)
interleukin 1 receptor antagonist,MVCD4,IRA |
Human | HEK293 Cells |
IL-1RA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.8 kDa and the accession number is P18510-1. | |||
TMPJ-00909 |
IL-1RA Protein, Mouse, Recombinant
IL-1RN,IRAP,Interleukin-1 |
Mouse | E. coli |
Interleukin-1 receptor antagonist protein (Il1rn), also known as IL-1ra, IRAP or IL1 inhibitor, is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. The mouse Il1rn gene encodes a 178 amino acids (aa) protein with a 26 aa signal peptide. Mouse Il1rn protein shares 26% and 19% identity with its homologues IL-1 beta and I... | |||
TMPY-05845 |
IL-1RA Protein, Cynomolgus, Recombinant (His)
interleukin 1 receptor antagonist |
Cynomolgus | E. coli |
IL-1RA Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 18.63 kDa and the accession number is Q866R8. | |||
TMPY-03081 |
IL-1RA Protein, Rat, Recombinant (hFc)
interleukin 1 receptor antagonist |
Rat | HEK293 Cells |
IL-1RA Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.8 kDa and the accession number is P25086. | |||
TMPY-05837 |
IL-1RA Protein, Rat, Recombinant (His)
interleukin 1 receptor antagonist |
Rat | E. coli |
IL-1RA Protein, Rat, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 19.01 kDa and the accession number is A6JSY4. |