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Cat. No.	Product Name	Target	Signaling Pathways
T20513	IDO1-IN-1 IDO1 inhibitor 1,2 HzBTZ,2-肼基苯并噻唑,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1	IDO	Metabolism
	IDO1-IN-1 (2 HzBTZ) 是一种吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂。
T11901	IDO1-IN-5	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1-IN-5 是可透过血脑屏障的、选择性的IDO1抑制剂，能够与缺乏血红素的 apo-IDO1 结合，但无法与成熟血红素的 IDO1 结合。
T11625	IDO1 and HDAC1 Inhibitor	Others	Others
	IDO1 and HDAC1 Inhibitor is a dual IDO1 and HDAC1 inhibitor (IC50s: 69.0 nM and 66.5 nM).
T11616	IDO-IN-13 GS-4361	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-13 (GS-4361) 是 indoleamine 2,3-dioxygenase 1 抑制剂，EC50=17 nM。
T4532	Linrodostat BMS-986205	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Linrodostat (BMS-986205) 是选择性的、不可逆的吲哚胺 2,3-双加氧酶 1(IDO1) 抑制剂，能够有效抑制 IDO1-HEK293 细胞，其IC50=1.1 nM。它在晚期癌症中具有良好的药理特性。
T9164	BMS-986242 BMS986242	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	BMS-986242 是具有口服具有活力、强效的、选择性的 indoleamine-2,3-dioxygenase 1 抑制剂，可用于研究癌症。
T61789	IDO1-IN-14
	IDO1-IN-14 (compound 4a) is a highly effective inhibitor of the IDO1 enzyme, exhibiting an IC50 value of 396.9 nM. Additionally, IDO1-IN-14 demonstrates excellent suppression of cellular IDO1 activity, as observed in HeLa cells with an EC50 value of 3393 nM [1].
T63780	IDO1-IN-16
	IDO1-IN-16 (I-1) 是一种 IDO1 抑制剂，能够靶向holo-IDO1 (IC50: 127 nM)。
T28175	Nitrobenzofuroxan NSC 228079,NSC-228079,B-2789,B 2789,B2789
	Nitrobenzofuroxan, is a HIV-1 and IDO1 inhibitor.
T73437	DP00477
	DP00477，一种高效IDO1(indoleamine 2,3-dioxygenase 1)抑制剂，IC50为7.0 µM，展现在癌症研究中的潜力。
T12668	(Rac)-IDO1-IN-5	Others	Others
	(Rac)-IDO1-IN-5 is a racemate of IDO1-IN-5, a potent, selective, and brain-penetrating inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity. It specifically binds to apo-IDO1, which lacks heme, instead of mature heme-bound IDO1.
T60499	IDO1/TDO-IN-2
	IDO1/TDO-IN-2 (Compound 1) 是有效的IDO1/TDO 双重抑制剂，IC50s 分别为 0.1 和 0.07 μM，具有癌症研究的潜力。
T61140	IDO1/TDO-IN-3
	IDO1/TDO-IN-3 is a powerful inhibitor targeting IDO1 and TDO enzymes. It displays noteworthy effectiveness against IDO1 (IC50: 0.005 μM) and TDO (IC50: 0.004 μM). Additionally, IDO1/TDO-IN-3 demonstrates considerable in vivo anti-tumor properties while exhibiting no apparent toxicity [1].
T63651	IDO1/2-IN-1 hydrochloride
	IDO1/2-IN-1 hydrochloride 是一个有效的 IDO1 (IC50: 28 nM) 和 IDO2 (IC50: 144 nM) 双重抑制剂，口服具有活力。IDO1/2-IN-1 hydrochloride 表现出抗肿瘤作用。
T63222	IDO1/2-IN-1
	IDO1/2-IN-1 是一个有效的、口服具有活力的 IDO1/IDO2 双重抑制剂，对 IDO1 和 IDO2 的IC50分别为 28 nM 和 144 nM，表现出抗肿瘤作用。
T60698	Roxyl-9
	Roxyl-9 是一种 IDO1 (吲哚胺2,3-双加氧酶1) 抑制剂。
T61385	IDO1/TDO-IN-1
	IDO1/TDO-IN-1 (30) is a highly effective inhibitor that targets both IDO1 and TDO enzymes with uncompetitive (Ki = 0.23 μM) and competitive (Ki = 0.73 μM) mechanisms, respectively. This compound, IDO1/TDO-IN-1 (30), exhibits a significant capacity to induce cell apoptosis via the potential mitochondria-mediated Bcl-2/Bax pathway [1].
T82082	IDO1-IN-23	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1-IN-23（化合物41）是一种有效的人类IDO1抑制剂，具备13 μM的IC50值。
T39888	IDO1-IN-7 IDO1-IN-7
	IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstrates immunomodulatory effects, contributing to its potential applications in cancer research.
T79189	1-Isopropyltryptophan 1-IsoPT	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	1-Isopropyltryptophan (1-IsoPT)为IDO1抑制剂，能够抑制IFN-γ刺激下IDO-1与IDO-2 mRNA的表达水平。
T73111	IDO1-IN-17
	IDO1-IN-17 (I-4) 是IDO1的抑制剂，其在 hela 细胞中的IC50值为 0.44 μM。
T78235	4-Phenyl-1H-1,2,3-triazole	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	4-Phenyl-1H-1,2,3-triazole，一种IDO1抑制剂（IC50：60 μM），可应用于癌症研究。
T78687	IDO1-IN-21	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1-IN-21（化合物10m）为IDO1抑制剂，其IC50值为0.64 μM。该化合物在小鼠体内可有效抑制肿瘤生长。
T78795	IDO1/TDO-IN-6	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1/TDO-IN-6（compound 11）为IDO1/TDO双重抑制剂，其IC50值分别为2.25 μM和2.89 μM。在抑制IDO1和TDO方面，其Ki值分别为1.9 μM和3.1 μM。IDO1/TDO-IN-6适用于癌症与免疫学领域的研究。
T78975	IDO1-IN-22	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1-IN-22（Compound 3）是一种效能显著的IDO1抑制剂，具备低纳摩尔级生化活性（hIDO1 IC50：67.4 nM）以及显著的细胞内抑制效果（HeLa细胞中hIDO1 IC50：17.6 nM）。在小鼠LLC异种移植模型中表现出卓越的抗肿瘤效果，并表现出有利的药代动力学（PK）特性。
T73512	ZC0109
	ZC0109 是 IDO1和硫氧还蛋白还原酶 1 (TrxR1) 的双抑制剂，IC50分别为 50 nM 和 3.0 μM。ZC0109 诱导活性氧 (ROS) 积累，使细胞周期阻滞于 G1/S 期，导致癌细胞凋亡 (apoptosis)。
T60618	ZC0101
	ZC0101 是一种有效的、具有口服活性的 IDO1和 TrxR 双重抑制剂，IC50值分别为 0.084 μM 和 7.98 μM。ZC0101 可诱导癌细胞的凋亡和活性氧的积累。
T36645	CAY10763 CAY10763
	CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50= 46 nM) and STAT3 activation.1It binds to STAT3 (Kd= 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position 705 (STAT3Y705) over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells when used at a concentration of 500 nM. It also inhibits STAT3 nuclear translocation in SKOV3 cells. CAY10763 is cytotoxic to HCT116, SKOV3, A549, and HepG2 cancer cells (IC50s = 37, 28, 33, and 12 nM...

化合物

Cat.No: T20513

Synonym: IDO1 inhibitor 1,2 HzBTZ,2-肼基苯并噻唑,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1

Target: IDO

Cat.No: T11901

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

IDO1 and HDAC1 Inhibitor

Cat.No: T11625

Target: Others

Cat.No: T11616

Synonym: GS-4361

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T4532

Synonym: BMS-986205

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T9164

Synonym: BMS986242

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T61789

Cat.No: T63780

Nitrobenzofuroxan

Cat.No: T28175

Synonym: NSC 228079,NSC-228079,B-2789,B 2789,B2789

Cat.No: T73437

(Rac)-IDO1-IN-5

Cat.No: T12668

Target: Others

IDO1/TDO-IN-2

Cat.No: T60499

IDO1/TDO-IN-3

Cat.No: T61140

IDO1/2-IN-1 hydrochloride

Cat.No: T63651

Cat.No: T63222

Cat.No: T60698

IDO1/TDO-IN-1

Cat.No: T61385

Cat.No: T82082

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T39888

Synonym: IDO1-IN-7

1-Isopropyltryptophan

Cat.No: T79189

Synonym: 1-IsoPT

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T73111

4-Phenyl-1H-1,2,3-triazole

Cat.No: T78235

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T78687

Target: Indoleamine 2,3-Dioxygenase (IDO)

IDO1/TDO-IN-6

Cat.No: T78795

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T78975

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T73512

Cat.No: T60618

Cat.No: T36645

Synonym: CAY10763

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