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Cat. No. | Product Name | Target | Signaling Pathways |
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T20513 |
IDO1-IN-1
IDO1 inhibitor 1,2 HzBTZ,2-肼基苯并噻唑,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1 |
IDO | Metabolism |
IDO1-IN-1 (2 HzBTZ) 是一种吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂。 | |||
T11624 | IDO1-IN-2 | IDO | Metabolism |
IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity. | |||
T60499 |
IDO1/TDO-IN-2
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IDO1/TDO-IN-2 (Compound 1) 是有效的IDO1/TDO 双重抑制剂,IC50s 分别为 0.1 和 0.07 μM,具有癌症研究的潜力。 | |||
T63222 | IDO1/2-IN-1 | ||
IDO1/2-IN-1 是一个有效的、口服具有活力的 IDO1/IDO2 双重抑制剂,对 IDO1 和 IDO2 的IC50分别为 28 nM 和 144 nM,表现出抗肿瘤作用。 | |||
T63651 | IDO1/2-IN-1 hydrochloride | ||
IDO1/2-IN-1 hydrochloride 是一个有效的 IDO1 (IC50: 28 nM) 和 IDO2 (IC50: 144 nM) 双重抑制剂,口服具有活力。IDO1/2-IN-1 hydrochloride 表现出抗肿瘤作用。 | |||
T1806 |
IDO-IN-7
NLG919,Navoximod,NLG-919 analogue,GDC-0919 |
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
IDO-IN-7 (NLG-919 analogue) 是 IDO1 抑制剂,IC50=38 nM。 | |||
T61385 |
IDO1/TDO-IN-1
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IDO1/TDO-IN-1 (30) is a highly effective inhibitor that targets both IDO1 and TDO enzymes with uncompetitive (Ki = 0.23 μM) and competitive (Ki = 0.73 μM) mechanisms, respectively. This compound, IDO1/TDO-IN-1 (30), exhibits a significant capacity to induce cell apoptosis via the potential mitochondria-mediated Bcl-2/Bax pathway [1]. | |||
T37329 |
PROTAC IDO1 Degrader-1
PROTAC IDO1 Degrader-1 |
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PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1]. PROTAC IDO1 Degrader-1 (compound 2c) (10 μM; 24 hours) notably decreases IDO1 level induced by IFN-γ[1].PROTAC IDO1 Degrader-1 and IFN-γ (5 ng/mL) are incubated with HeLa cells for 24... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T3S1967 |
(S)-Indoximod
N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine |
Others; Indoleamine 2,3-Dioxygenase (IDO) | Metabolism; Others |
(S)-Indoximod (L-Abrine) 是一种吲哚胺-2,3-双加氧酶 (IDO) 抑制剂,可用于研究癌症。 |