Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP2016 |
Huwentoxin-IV
Huwentoxin IV |
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Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). Inhibits the channel by binding at the neurotoxin recepto | |||
T75856 |
Huwentoxin-IV TFA
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Huwentoxin-IV TFA是一种具有高效性和选择性的钠通道阻滞剂,能够抑制Nav1.7、Nav1.2、Nav1.3和Nav1.4神经元,其IC50分别为26、150、338和400nM。通过优先结合于神经毒素受体位点4,Huwentoxin-IV TFA特异性地阻断周围神经的Nav1.7亚型。该化合物适用于炎症性及神经性疼痛动物模型的研究。 | |||
T80519 |
m3-Huwentoxin IV
m3-HwTx-IV |
Sodium Channel | Membrane transporter/Ion channel |
m3-Huwentoxin IV (m3-HwTx-IV) 是针对多种 hNaV 子型的有效 NaV 抑制剂,其 IC50 值针对 hNaV1.7、hNaV1.6、hNaV1.3、hNaV1.1、hNaV1.2 和 hNaV1.4 分别为 3.3、6.8、7.2、8.4、11.9 和 369 nM。该化合物还能剂量依赖性地抑制 OD1 激活剂诱导的小鼠 NaV1.7 导致的疼痛反应。 | |||
T80495 |
mHuwentoxin-IV
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Sodium Channel | Membrane transporter/Ion channel |
mHuwentoxin-IV是一种经天然修饰的Huwentoxin-IV。该化合物针对背根神经节中河豚毒素敏感(TTX-S)电压门控钠通道(sodium channels)表现出抑制作用,IC50值为54.16 nM。mHuwentoxin-IV对这些钠通道的抑制作用并不会因强去极化电压而逆转。 |