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Search Results for " hpgds "

Targets Recommended: PGE Synthase

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T1804	HPGDS inhibitor 1 HPGDS-inhibitor-1	PGE Synthase	Immunology/Inflammation
	HPGDS inhibitor 1 是口服具有活性的HPGDS 选择性抑制剂，在酶和细胞分析中的IC50值分别为 0.6 nM 和 32 nM，但对 L-PGDS、mPGES、COX-1、COX-2 、5-LOX 无抑制作用。
T2681	hPGDS-IN-1	PGE Synthase	Immunology/Inflammation
	hPGDS-IN-1是 hPGDS 抑制剂，使用荧光偏振检测或通过 EIA 法测得的 IC50值为12 nM。
T7948	HPGDS inhibitor 2 GSK-2894631A	PGE Synthase	Immunology/Inflammation
	HPGDS inhibitor 2 (GSK-2894631A) 是高效的造血前列腺素 D 合成酶(H-PGDS)选择性抑制剂(IC50:9.9 nM)。
T61250	HPGDS inhibitor 3
	HPGDS inhibitor 3 is a powerful oral compound that selectively inhibits the hematopoietic prostaglandin D synthase (H-PGDS). With an IC50 value of 9.4 nM and EC50 of 42 nM, it demonstrates high potency in peripherally restricting H-PGDS. Moreover, HPGDS inhibitor 3 exhibits excellent selectivity with no associated central nervous system toxicity. This compound also possesses favorable pharmacokinetic properties in mouse, rat, and dog models. Additionally, HPGDS inhibitor 3 displays noteworthy an...
T41267	PROTAC(H-PGDS)-7
	PROTAC(H-PGDS)-7 是一种有选择性的、有效的小分子造血前列腺素 D 合酶（H-PGDS）PROTAC 降解剂，在 KU812细胞中展现出降解活性，DC50为 17.3 pM。PROTAC(H-PGDS)-7是一种类药化合物，能有效抑制前列腺素 D2 (PGD2)的产生，抑制炎症因子重生作用。PROTAC(H-PGDS)-7是治疗 DMD 和其他H-PGDS 相关疾病的候选化合物。
T15503	HQL-79	Others	Others
	HQL-79 is a selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor. It inhibits the synthesis of PGD2 and acts as an anti-allergic agent (Kd: 0.8 μM and IC50: 6 μM). It also shows no obvious effect on COX-1, COX-2, m-P

化合物

HPGDS inhibitor 1

Cat.No: T1804

Synonym: HPGDS-inhibitor-1

Target: PGE Synthase

hPGDS-IN-1

Cat.No: T2681

Synonym:

Target: PGE Synthase

HPGDS inhibitor 2

Cat.No: T7948

Synonym: GSK-2894631A

Target: PGE Synthase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04077	HPGDS/PGD2 Protein, Human, Recombinant (His) hematopoietic prostaglandin D synthase,PGD2,GSTS1-1,GSTS1,PG...	Human	E. coli
	HPGDS/PGD2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 24.2 kDa and the accession number is O60760.
TMPJ-00690	PGDS Protein, Human, Recombinant Glutathione-Requiring Prostaglandin D Synthase,PGDS,Glutathi...	Human	E. coli
	Hematopoietic Prostaglandin D Synthase (HPGDS) belongs to the GST superfamily and Sigma family. HPGDS contains one GST C-terminal domain and one GST N-terminal domain. HPGDS is highly expressed in adipose tissue, macrophages, and placenta, and it exists in the form of homodimer in living body. HPGDS is a cytosolic enzyme that isomerizes PGH(2). HPGDS is a bifunctional enzyme that catalyzes both the conversion of PGH2 to PGD2 and also shows low glutathione-peroxidase activity towards cumenehydrop...