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Cat. No. | Product Name | Target | Signaling Pathways |
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T11566 |
HIV-1 integrase inhibitor
|
Others | Others |
Hiv-1 integrase inhibitor is an effective anti-HIV drug. | |||
T11567 |
HIV-1 integrase inhibitor 3
|
Others | Others |
HIV-1 integrase inhibitor 3 is an HIV-1 integrase strand transfer (INST) inhibitor (IC50: 2.7 nM). | |||
T11565 |
HIV-1 integrase inhibitor 7
|
Others | Others |
HIV-1 integrase inhibitor 7 is a potent HIV-1 integrase inhibitor (IC50: 33.3 nM). | |||
T11568 |
HIV-1 integrase inhibitor 4
|
Others | Others |
HIV-1 integrase inhibitor 4 is an HIV-1 integrase strand transfer (INST) inhibitor (IC50: 3.7 nM). | |||
T4182 |
lavendustin B
薰草菌素B |
Tyrosinase; transporter; HIV Protease | Metabolism; Microbiology/Virology; Proteases/Proteasome |
Lavendustin B 是一种酪氨酸激酶抑制剂,是 HIV-1 整合酶 (IN) 与其同源细胞辅助因子、晶状体上皮衍生生长因子 (LEDGF/p75) 相互作用的抑制剂。 | |||
T60742 |
HIV-1 integrase inhibitor 8
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-1 integrase inhibitor 8 是一种 HIV-1 整合酶抑制剂,整合是HIV 复制的必要步骤。 | |||
T9854 |
HIV-1 inhibitor-6
3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo- |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) 是一种有效的HIV-1 pre-mRNA 选择性剪接抑制剂,可以阻断HIV 复制。 | |||
T6420 |
BMS-707035
N-[(4-氟苯基)甲基1,6-二氢-5-羟基-1-甲基-6-氧代-2-(四氢-1,1-二氧-2H-1,2-噻嗪-2-基)-4-嘧啶甲酰胺 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
BMS707035是一种 HIV-1 整合酶抑制剂,IC50为15 nM。 | |||
T15483 |
LEDGIN6
HIV-1 integrase inhibitor 2 |
Others | Others |
HIV-1 integrase inhibitor 2 is used for the treatment of human immunodeficiency virus (HIV) infection. | |||
T62156 |
HIV-1 integrase inhibitor 9
|
||
HIV-1 integrase inhibitor 9 (compound 8a) 是一种 HIV-1 RNase H 的有效抑制剂 (IC50: 12.3 μM),具有抗病毒作用。 | |||
T72162 | HIV-1 integrase inhibitor 10 | ||
HIV-1integrase inhibitor 10 是一种 HIV-1变构整合酶抑制剂 (ALLINI),具有口服活性。HIV-1integrase inhibitor 10 可抑制 NLRepRluc 病毒在 MT-2 细胞中的生长,其 EC50值为 3-5 nM。HIV-1integrase inhibitor 10 可用于人类免疫缺陷病毒-1 (HIV-1) 的研究。 | |||
T6098 |
Cabotegravir
GSK744,GSK-1265744,卡博特韦,S/GSK1265744 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Cabotegravir (S/GSK1265744) 是一种HIV 整合酶抑制剂,可研究艾滋病。它抑制OAT1 和OAT3,IC50值为 0.81 和0.41 μM。 | |||
T4493 |
Bictegravir
GS-9883 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Bictegravir (GS-9883) 是一种 HIV-1 整合酶抑制剂,其IC50值为 7.5 nM。 | |||
T35340 |
Bictegravir Sodium
GS-9883 Sodium |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Bictegravir Sodium (GS-9883 Sodium) 是一种有效的 HIV-1 整合酶抑制剂,其 IC50 值为 7.5 nM。Bictegravir Sodium 表现出强大的选择性的抗 HIV 活性和低的细胞毒性。 | |||
T2329 |
Dolutegravir sodium
度鲁特韦钠,GSK1349572,度鲁特韦钠盐,GSK-1349572A |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Dolutegravir sodium (GSK-1349572A) 是一种高效、口服的 HIV 整合酶链转移抑制剂,在 HIV-1 整合酶催化的链转移中的 IC50值为 2.7 nM, 抑制 HIV-1 病毒在外周血单个核细胞中的复制,IC50为 0.51 nM。它对 Y143R,N155H 和 G140S/Q148H 突变体也保持高效。 | |||
T6198 |
Dolutegravir
S/GSK1349572,GSK1349572,度鲁特韦,多替拉韦 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Dolutegravir (GSK1349572) 是口服HIV 整合酶链转移高效抑制剂,抑制 HIV-1 病毒在外周血单个核细胞中的复制。它对耐拉替拉韦的特征突变体 Y143R、Q148K、N155H 和 G140S/Q148H 具有中等活性。 | |||
T11074 |
Dolutegravir intermediate-1
1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid,1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Dolutegravir intermediate-1 (1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid) 是 Dolutegravir 的一种新合成中间体。 它是一种整合酶抑制剂,有潜力研究人类免疫缺陷病毒 (HIV)-1 感染。 | |||
T24752 |
S-1360
GW810781,GW-810781,GSK-S-1360,S1360,S 1360 |
||
S-1360 is an inhibitor of HIV-1 integrase. | |||
T31125 | CX14442 Sodium | ||
Cx14442 sodium is a new effective HIV-1 integrase inhibitor. | |||
T68414 |
5-ClTEP
|
||
5-ClTEP is a HIV-1 integrase inhibitor. | |||
T79021 | GSK3839919A | ||
GSK3839919A为高效HIV-1整合酶抑制剂。 | |||
T64096 |
Integrase-LEDGF/p75 allosteric inhibitor 1
|
||
Integrase-LEDGF/p75 allosteric inhibitor 1 是一种口服具有活力的 integrase-LEDGF/p75 (IN-LEDGF/p75) 变构抑制剂。Integrase-LEDGF/p75 allosteric inhibitor 1 能够抑制 HIV-1 DNA 整合,表现出抗病毒作用,能够作用于 HIV-1重组分子克隆 NL432 (EC50: 3.9 nM)。 | |||
T24366 |
L 870810
L-870,810,L870810,L 870,810,L870,810,L-870810 |
||
L 870810 is a small-molecule inhibitor of HIV-1 integrase with potent antiviral activity in cell culture and good pharmacokinetic properties. | |||
T14559 |
BI 224436
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains. | |||
T73524 | XZ426 | ||
XZ426 是一种有效的整合酶链转移抑制剂,具有抗HIV 活性。 | |||
T68364 |
GS-9160
|
||
GS-9160 is a novel and potent inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (IN) that specifically targets the process of strand transfer. It is an authentic inhibitor of HIV-1 integration, since treatment of infected cells results in an elevation of two-long terminal repeat circles and a decrease of integration junctions. | |||
T36793 |
Dolutegravir M1
|
||
Dolutegravir M1 is a metabolite of the HIV integrase inhibitor dolutegravir .1It is formed primarily by the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1. 1.Zhu, J., Wang, P., Li, F., et al.CYP1A1 and 1B1-mediated metabolic pathways of dolutegravir, an HIV integrase inhibitorBiochem. Pharmacol.158174-184(2018) | |||
T70881 | Dolutegravir RR Isomer | ||
Dolutegravir RR Isomer is an isomer of Dolutegravir -- a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector. | |||
T63977 |
GSK3739936
|
||
GSK3739936 是 HIV-1 变构整合酶 (HIV-1 allosteric integrase) 的有效抑制剂 (IC50: 11.1 nM, EC50: 1.7 nM)。GSK3739936 也是一种 CYP 的弱抑制剂,其IC50>24.3 μM。GSK3739936 在实验动物中具有良好的药代动力学特性,吸收快、清除率低至中等,以及口服生物利用度良好。 | |||
T71009 |
Dolutegravir SR Isomer
|
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Dolutegravir SR Isomer is an isomeric derivative of Dolutegravir -- a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector. | |||
T36794 |
Dolutegravir O-β-D-Glucuronide
|
||
Dolutegravir O-β-D-glucuronide is a metabolite of the HIV integrase inhibitor dolutegravir .1It is formed from dolutegravir primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1in vivobut is also metabolized by UGT1A9 in human liver and kidney microsomes and UGT1A3 in human intestinal microsomes.2,1 1.Liu, S.N., Lu, J.B., Watson, C.J.W., et al.Mechanistic assessment of extrahepatic contributions to glucuronidation of integrase strand transfer inhibitorsDrug Metab. Dispos.47(5)535-544... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6S2391 |
L-Chicoric Acid
(-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸 |
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
L-Chicoric Acid (trans-Caffeoyltartaric acid) 是一种二咖啡酰酒石酸,是一种选择性可逆的 HIV-1 整合酶抑制剂,IC50约为 100 nM。它还可抑制 HIV-1 复制。 | |||
TL0006 |
Cichoric Acid
菊苣酸,Dicaffeoyltartaric acid,Chicoric Acid |
Reactive Oxygen Species; HIV Protease | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
Cichoric Acid (Dicaffeoyltartaric acid) 是一种天然化合物,具有抗氧化作用。 | |||
T11219 |
Equisetin
|
Others | Others |
Equisetin, an N-methylserine-derived acyl tetramic acid isolated from the terrestrial fungus Fusarium equiseti NRRL 5537, functions as a Quorum-sensing inhibitor (QSI) that specifically attenuates QS-regulated virulence phenotypes in P. aeruginosa, presenting a potent lead for treating P. aeruginosa infections without hindering bacterial growth. This tetramate-containing natural product possesses antibiotic and cytotoxic properties, effectively inhibiting the growth of Gram-positive bacteria and... |