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31

抑制剂 & 化合物

3

天然产物

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Cat. No. Product Name Target Signaling Pathways
T11566 HIV-1 integrase inhibitor

Others Others
Hiv-1 integrase inhibitor is an effective anti-HIV drug.
T11565 HIV-1 integrase inhibitor 7

Others Others
HIV-1 integrase inhibitor 7 is a potent HIV-1 integrase inhibitor (IC50: 33.3 nM).
T11568 HIV-1 integrase inhibitor 4

Others Others
HIV-1 integrase inhibitor 4 is an HIV-1 integrase strand transfer (INST) inhibitor (IC50: 3.7 nM).
T11567 HIV-1 integrase inhibitor 3

Others Others
HIV-1 integrase inhibitor 3 is an HIV-1 integrase strand transfer (INST) inhibitor (IC50: 2.7 nM).
T4182 lavendustin B

薰草菌素B

Tyrosinase; transporter; HIV Protease Metabolism; Microbiology/Virology; Proteases/Proteasome
Lavendustin B 是一种酪氨酸激酶抑制剂,是 HIV-1 整合酶 (IN) 与其同源细胞辅助因子、晶状体上皮衍生生长因子 (LEDGF/p75) 相互作用的抑制剂。
T60742 HIV-1 integrase inhibitor 8

HIV Protease Microbiology/Virology; Proteases/Proteasome
HIV-1 integrase inhibitor 8 是一种 HIV-1 整合酶抑制剂,整合是HIV 复制的必要步骤。
T9854 HIV-1 inhibitor-6 

3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-

HIV Protease Microbiology/Virology; Proteases/Proteasome
HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) 是一种有效的HIV-1 pre-mRNA 选择性剪接抑制剂,可以阻断HIV 复制。
T6420 BMS-707035

N-[(4-氟苯基)甲基1,6-二氢-5-羟基-1-甲基-6-氧代-2-(四氢-1,1-二氧-2H-1,2-噻嗪-2-基)-4-嘧啶甲酰胺

HIV Protease Microbiology/Virology; Proteases/Proteasome
BMS707035是一种 HIV-1 整合酶抑制剂,IC50为15 nM。
T15483 LEDGIN6

HIV-1 integrase inhibitor 2

Others Others
HIV-1 integrase inhibitor 2 is used for the treatment of human immunodeficiency virus (HIV) infection.
T72162 HIV-1 integrase inhibitor 10

HIV-1integrase inhibitor 10 是一种 HIV-1变构整合酶抑制剂 (ALLINI),具有口服活性。HIV-1integrase inhibitor 10 可抑制 NLRepRluc 病毒在 MT-2 细胞中的生长,其 EC50值为 3-5 nM。HIV-1integrase inhibitor 10 可用于人类免疫缺陷病毒-1 (HIV-1) 的研究。
T62156 HIV-1 integrase inhibitor 9

HIV-1 integrase inhibitor 9 (compound 8a) 是一种 HIV-1 RNase H 的有效抑制剂 (IC50: 12.3 μM),具有抗病毒作用。
T6098 Cabotegravir

GSK744,GSK-1265744,卡博特韦,S/GSK1265744

HIV Protease Microbiology/Virology; Proteases/Proteasome
Cabotegravir (S/GSK1265744) 是一种HIV 整合酶抑制剂,可研究艾滋病。它抑制OAT1 和OAT3,IC50值为 0.81 和0.41 μM。
T4493 Bictegravir

GS-9883

HIV Protease Microbiology/Virology; Proteases/Proteasome
Bictegravir (GS-9883) 是一种 HIV-1 整合酶抑制剂,其IC50值为 7.5 nM。
T35340 Bictegravir Sodium

GS-9883 Sodium

HIV Protease Microbiology/Virology; Proteases/Proteasome
Bictegravir Sodium (GS-9883 Sodium) 是一种有效的 HIV-1 整合酶抑制剂,其 IC50 值为 7.5 nM。Bictegravir Sodium 表现出强大的选择性的抗 HIV 活性和低的细胞毒性。
T2329 Dolutegravir sodium

度鲁特韦钠,GSK1349572,度鲁特韦钠盐,GSK-1349572A

HIV Protease Microbiology/Virology; Proteases/Proteasome
Dolutegravir sodium (GSK-1349572A) 是一种高效、口服的 HIV 整合酶链转移抑制剂,在 HIV-1 整合酶催化的链转移中的 IC50值为 2.7 nM, 抑制 HIV-1 病毒在外周血单个核细胞中的复制,IC50为 0.51 nM。它对 Y143R,N155H 和 G140S/Q148H 突变体也保持高效。
T6198 Dolutegravir

S/GSK1349572,GSK1349572,度鲁特韦,多替拉韦

HIV Protease Microbiology/Virology; Proteases/Proteasome
Dolutegravir (GSK1349572) 是口服HIV 整合酶链转移高效抑制剂,抑制 HIV-1 病毒在外周血单个核细胞中的复制。它对耐拉替拉韦的特征突变体 Y143R、Q148K、N155H 和 G140S/Q148H 具有中等活性。
T11074 Dolutegravir intermediate-1

1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid,1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

HIV Protease Microbiology/Virology; Proteases/Proteasome
Dolutegravir intermediate-1 (1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid) 是 Dolutegravir 的一种新合成中间体。 它是一种整合酶抑制剂,有潜力研究人类免疫缺陷病毒 (HIV)-1 感染。
T24752 S-1360

GW810781,GW-810781,GSK-S-1360,S1360,S 1360

S-1360 is an inhibitor of HIV-1 integrase.
T31125 CX14442 Sodium

Cx14442 sodium is a new effective HIV-1 integrase inhibitor.
T68414 5-ClTEP

5-ClTEP is a HIV-1 integrase inhibitor.
T79021 GSK3839919A

GSK3839919A为高效HIV-1整合酶抑制剂。
T64096 Integrase-LEDGF/p75 allosteric inhibitor 1

Integrase-LEDGF/p75 allosteric inhibitor 1 是一种口服具有活力的 integrase-LEDGF/p75 (IN-LEDGF/p75) 变构抑制剂。Integrase-LEDGF/p75 allosteric inhibitor 1 能够抑制 HIV-1 DNA 整合,表现出抗病毒作用,能够作用于 HIV-1重组分子克隆 NL432 (EC50: 3.9 nM)。
T14559 BI 224436

HIV Protease Microbiology/Virology; Proteases/Proteasome
BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.
T24366 L 870810

L-870,810,L870810,L 870,810,L870,810,L-870810

L 870810 is a small-molecule inhibitor of HIV-1 integrase with potent antiviral activity in cell culture and good pharmacokinetic properties.
T73524 XZ426

XZ426 是一种有效的整合酶链转移抑制剂,具有抗HIV 活性。
T68364 GS-9160

GS-9160 is a novel and potent inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (IN) that specifically targets the process of strand transfer. It is an authentic inhibitor of HIV-1 integration, since treatment of infected cells results in an elevation of two-long terminal repeat circles and a decrease of integration junctions.
T36793 Dolutegravir M1

Dolutegravir M1 is a metabolite of the HIV integrase inhibitor dolutegravir .1It is formed primarily by the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1. 1.Zhu, J., Wang, P., Li, F., et al.CYP1A1 and 1B1-mediated metabolic pathways of dolutegravir, an HIV integrase inhibitorBiochem. Pharmacol.158174-184(2018)
T70881 Dolutegravir RR Isomer

Dolutegravir RR Isomer is an isomer of Dolutegravir -- a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
T63977 GSK3739936

GSK3739936 是 HIV-1 变构整合酶 (HIV-1 allosteric integrase) 的有效抑制剂 (IC50: 11.1 nM, EC50: 1.7 nM)。GSK3739936 也是一种 CYP 的弱抑制剂,其IC50>24.3 μM。GSK3739936 在实验动物中具有良好的药代动力学特性,吸收快、清除率低至中等,以及口服生物利用度良好。
T71009 Dolutegravir SR Isomer

Dolutegravir SR Isomer is an isomeric derivative of Dolutegravir -- a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
T36794 Dolutegravir O-β-D-Glucuronide

Dolutegravir O-β-D-glucuronide is a metabolite of the HIV integrase inhibitor dolutegravir .1It is formed from dolutegravir primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1in vivobut is also metabolized by UGT1A9 in human liver and kidney microsomes and UGT1A3 in human intestinal microsomes.2,1 1.Liu, S.N., Lu, J.B., Watson, C.J.W., et al.Mechanistic assessment of extrahepatic contributions to glucuronidation of integrase strand transfer inhibitorsDrug Metab. Dispos.47(5)535-544...

化合物

HIV-1 integrase inhibitor
Cat.No: T11566
Synonym:
Target: Others
HIV-1 integrase inhibitor 7
Cat.No: T11565
Synonym:
Target: Others
HIV-1 integrase inhibitor 4
Cat.No: T11568
Synonym:
Target: Others
HIV-1 integrase inhibitor 3
Cat.No: T11567
Synonym:
Target: Others
lavendustin B
Cat.No: T4182
Synonym: 薰草菌素B
Target: Tyrosinase, transporter, HIV Protease
HIV-1 integrase inhibitor 8
Cat.No: T60742
Synonym:
Target: HIV Protease
HIV-1 inhibitor-6 
Cat.No: T9854
Synonym: 3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-
Target: HIV Protease
BMS-707035
Cat.No: T6420
Synonym: N-[(4-氟苯基)甲基1,6-二氢-5-羟基-1-甲基-6-氧代-2-(四氢-1,1-二氧-2H-1,2-噻嗪-2-基)-4-嘧啶甲酰胺
Target: HIV Protease
LEDGIN6
Cat.No: T15483
Synonym: HIV-1 integrase inhibitor 2
Target: Others
HIV-1 integrase inhibitor 10
Cat.No: T72162
Synonym:
Target:
HIV-1 integrase inhibitor 9
Cat.No: T62156
Synonym:
Target:
Cabotegravir
Cat.No: T6098
Synonym: GSK744,GSK-1265744,卡博特韦,S/GSK1265744
Target: HIV Protease
Bictegravir
Cat.No: T4493
Synonym: GS-9883
Target: HIV Protease
Bictegravir Sodium
Cat.No: T35340
Synonym: GS-9883 Sodium
Target: HIV Protease
Dolutegravir sodium
Cat.No: T2329
Synonym: 度鲁特韦钠,GSK1349572,度鲁特韦钠盐,GSK-1349572A
Target: HIV Protease
Dolutegravir
Cat.No: T6198
Synonym: S/GSK1349572,GSK1349572,度鲁特韦,多替拉韦
Target: HIV Protease
Dolutegravir intermediate-1
Cat.No: T11074
Synonym: 1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid,1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
Target: HIV Protease
S-1360
Cat.No: T24752
Synonym: GW810781,GW-810781,GSK-S-1360,S1360,S 1360
Target:
CX14442 Sodium
Cat.No: T31125
Synonym:
Target:
5-ClTEP
Cat.No: T68414
Synonym:
Target:
GSK3839919A
Cat.No: T79021
Synonym:
Target:
Integrase-LEDGF/p75 allosteric inhibitor 1
Cat.No: T64096
Synonym:
Target:
BI 224436
Cat.No: T14559
Synonym:
Target: HIV Protease
L 870810
Cat.No: T24366
Synonym: L-870,810,L870810,L 870,810,L870,810,L-870810
Target:
XZ426
Cat.No: T73524
Synonym:
Target:
GS-9160
Cat.No: T68364
Synonym:
Target:
Dolutegravir M1
Cat.No: T36793
Synonym:
Target:
Dolutegravir RR Isomer
Cat.No: T70881
Synonym:
Target:
GSK3739936
Cat.No: T63977
Synonym:
Target:
Dolutegravir SR Isomer
Cat.No: T71009
Synonym:
Target:
Dolutegravir O-β-D-Glucuronide
Cat.No: T36794
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T6S2391 L-Chicoric Acid

(-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸

Others; HIV Protease Microbiology/Virology; Others; Proteases/Proteasome
L-Chicoric Acid (trans-Caffeoyltartaric acid) 是一种二咖啡酰酒石酸,是一种选择性可逆的 HIV-1 整合酶抑制剂,IC50约为 100 nM。它还可抑制 HIV-1 复制。
TL0006 Cichoric Acid

菊苣酸,Dicaffeoyltartaric acid,Chicoric Acid

Reactive Oxygen Species; HIV Protease Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
Cichoric Acid (Dicaffeoyltartaric acid) 是一种天然化合物,具有抗氧化作用。
T11219 Equisetin

Others Others
Equisetin, an N-methylserine-derived acyl tetramic acid isolated from the terrestrial fungus Fusarium equiseti NRRL 5537, functions as a Quorum-sensing inhibitor (QSI) that specifically attenuates QS-regulated virulence phenotypes in P. aeruginosa, presenting a potent lead for treating P. aeruginosa infections without hindering bacterial growth. This tetramate-containing natural product possesses antibiotic and cytotoxic properties, effectively inhibiting the growth of Gram-positive bacteria and...

天然产物

L-Chicoric Acid
Cat.No: T6S2391
Synonym: (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸
Target: Others, HIV Protease
Cichoric Acid
Cat.No: TL0006
Synonym: 菊苣酸,Dicaffeoyltartaric acid,Chicoric Acid
Target: Reactive Oxygen Species, HIV Protease
Equisetin
Cat.No: T11219
Synonym:
Target: Others
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