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Search Results for " hif1 "

Targets Recommended: HIF

8

抑制剂 & 化合物

1

化合物库

4

重组蛋白

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Cat. No.	Product Name
L8500	HIF-1化合物库		1336 compounds
	1336 个HIF-1相关小分子的独特集合，可用于缺血性疾病、癌症等相关领域的药物开发和药理研究；

化合物库

HIF-1化合物库

Cat.No: L8500

Compounds: 1336

Cat. No.	Product Name	Target	Signaling Pathways
T9890	HIF1-IN-3 Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-	HIF	Angiogenesis; Chromatin/Epigenetic
	HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) 是HIF-1的有效抑制剂（EC50 = 0.9 μM）,可用于抗癌的研究。
T36290	HIF-1 inhibitor-1
	HIF-1 inhibitor-1 is an aryl carboxamide compound and a potent hypoxia-inducible factor 1 (HIF-1) inhibitor with an IC50 of 0.32 μM for the cancer metastasi[1]. [1]. Liu M, et al. Discovery of Novel Aryl Carboxamide Derivatives as Hypoxia-Inducible Factor 1α Signaling Inhibitors with Potent Activities of Anticancer Metastasis. J Med Chem. 2019 Oct 24;62(20):9299-9314.
TP1533	HIF-1 alpha (556-574) HIF-1 alpha 556-574
	HIF-1 alpha (556-574) is a hypoxia-inducible factor-1 19-mer fragment. HIF-1 functions as master regulator of response to oxygen homeostasis. Hypoxia-induced gene expression is initiated when HIF-1subunit is stabilized in response to a lack of oxygen. Thi
TP1546	HIF-1 alpha (556-574) TFA (1201633-99-9 free base) HIF-1 alpha (556-574) TFA
	This is a hypoxia-inducible factor-1 (HIF-1 a) 19-mer fragment. HIF-1 functions as master regulator of response to oxygen homeostasis. Hypoxia-induced gene expression is initiated when HIF-1 subunit is stabilized in response to a lack of oxygen. This part
T2389	Dapagliflozin 达格列净,BMS-512148	SGLT; HIF	Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein
	Dapagliflozin (BMS-512148) 竞争性的葡萄糖协同转运蛋白2 (SGLT2) 抑制剂，可促进尿液中葡萄糖的排泄，在糖尿病 (DM) 研究中具有价值。Dapagliflozin 诱导 HIF1表达并减轻肾脏 IR 损伤。
T67767	HIF-1 inhibitor-4 HIF-1 inhibitor-4	HIF	Angiogenesis; Chromatin/Epigenetic
	HIF-1 inhibitor-4 (HIF-1 inhibitor-4) 是一种 HIF-1 抑制剂 (IC50: 560 nM)。HIF-1 inhibitor-4 减少 HIF-1α 蛋白水平，但不影响 mRNA 水平。
T15396	GN44028 N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine	HIF	Angiogenesis; Chromatin/Epigenetic
	GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) 是缺氧诱导因子(HIF)-1的有效抑制剂，其 IC50=14 nM。它可以抑制低氧诱导的 HIF-1α 的转录特性，但不抑制 HIF-1α mRNA 的表达，HIF-1α 蛋白的累积或HIF-1α/HIF-1β 的异缘二聚化。
T4460	Dapagliflozin ((2S)-1,2-propanediol, hydrate) BMS-512148 (2S)-1,2-propanediol, hydrate,达格列净 (2S)-1,2-丙二醇水合物,Dapagliflozin propanediol monohydrate	SGLT	GPCR/G Protein
	Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) 是 Dapagliflozin 1,2-propanediol, hydrate 的 S 型异构体，是竞争性葡萄糖协同转运蛋白2 抑制剂，可促进尿液中葡萄糖的排泄，可用于糖尿病的研究。它诱导 HIF1表达并减轻肾脏 IR 损伤。

化合物

Cat.No: T9890

Synonym: Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-

Target: HIF

HIF-1 inhibitor-1

Cat.No: T36290

HIF-1 alpha (556-574)

Cat.No: TP1533

Synonym: HIF-1 alpha 556-574

HIF-1 alpha (556-574) TFA (1201633-99-9 free base)

Cat.No: TP1546

Synonym: HIF-1 alpha (556-574) TFA

Cat.No: T2389

Synonym: 达格列净,BMS-512148

Target: SGLT, HIF

HIF-1 inhibitor-4

Cat.No: T67767

Synonym: HIF-1 inhibitor-4

Target: HIF

Cat.No: T15396

Synonym: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine

Target: HIF

Dapagliflozin ((2S)-1,2-propanediol, hydrate)

Cat.No: T4460

Synonym: BMS-512148 (2S)-1,2-propanediol, hydrate,达格列净 (2S)-1,2-丙二醇水合物,Dapagliflozin propanediol monohydrate

Target: SGLT

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01709	HIF-1 alpha Protein, Human, Recombinant (His) bHLHe78,HIF-1 α,hypoxia inducible factor <...	Human	E. coli
	HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has...
TMPH-00957	ARNT Protein, Human, Recombinant (His) Hypoxia-inducible factor 1-beta,Class E basic helix...	Human	P. pastoris (Yeast)
	ARNT Protein, Human, Recombinant (His) is expressed in Yeast.
TMPH-01512	HIF1AN Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and severa...
TMPH-01280	EGLN1 Protein, Human, Recombinant (His & Myc) HPH-2,EGLN1,PHD2,SM-20,HIF-prolyl hydroxyl...	Human	E. coli
	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquiti...

重组蛋白

HIF-1 alpha Protein, Human, Recombinant (His)

Cat.No: TMPY-01709

Species: Human

Expression System: E. coli

ARNT Protein, Human, Recombinant (His)

Cat.No: TMPH-00957

Species: Human

Expression System: P. pastoris (Yeast)

HIF1AN Protein, Human, Recombinant (His)

Cat.No: TMPH-01512

Species: Human

Expression System: P. pastoris (Yeast)

EGLN1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01280

Species: Human

Expression System: E. coli

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