Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0455 |
Clozapine
氯氮平,HF 1854,LX 100-129 |
Dopamine Receptor; Adrenergic Receptor; AChR | GPCR/G Protein; Neuroscience |
Clozapine (HF 1854) 是一种三环二苯二氮卓类药物,属于非典型抗精神病药物。它结合几种类型的中枢神经系统受体,并显示出独特的药理学特征。 它是一种血清素拮抗剂,与 5-HT 2A/2C 受体亚型具有强结合力。它还对几种多巴胺能受体表现出很强的亲和力,但对多巴胺 D2 受体仅表现出较弱的拮抗作用,这种受体通常被认为可调节精神抑制活性。 | |||
T69129 |
Clozapine HCl
|
||
Clozapine HCl is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a ... |