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Cat. No.	Product Name	Target	Signaling Pathways
T9577	HCV-IN-31	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	HCV-IN-31 是一种HCV 抑制剂，EC50/EC95值为15.7 μM。
T15573	Inarigivir soproxil SB9200	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Inarigivir soproxil (SB9200) 是一种先天免疫激动剂。它还显示出针对耐药丙型肝炎病毒 (HCV) 变体的有效抗病毒活性。在基因型 1 HCV 复制子系统细胞中， HCV 1a/1b 的 EC50 为 2.2 和 1.0 μM。
T6229	Daclatasvir Daklinza,达卡他韦,EBP 883,达拉他韦,BMS-790052	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Daclatasvir (EBP 883) 是一种高度选择性的 HCV NS5A 抑制剂，EC50 为 9-50 pM，适用于细胞培养中的多种 HCV 复制子基因型和 JFH-1 基因型 2a 感染性病毒。
T1786	Daclatasvir dihydrochloride BMS-790052 dihydrochloride,盐酸达拉他韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) 是有机阴离子转运多肽 1B(OATP1B) 和 OATP1B3抑制剂，IC50分别为 1.5 µM 和 3.27 µM。它也具有口服活性的 HCV NS5A 蛋白抑制剂，多种 HCV 复制子基因型的 EC50范围为 9-146 pM。
T22142	RO8191 RO4948191,CDM-3008	HCV Protease; HBV; JAK; IFNAR; STAT	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells
	RO8191 (CDM-3008) 是干扰素 (IFN) 受体激动剂。它直接与 IFNα/β 受体 2 结合，激活 IFN 刺激的基因表达和 JAK/STAT 磷酸化。它通过具有干扰素样活性发挥 cccDNA 调节剂作用，并具有抗 HBV 活性。
TQ0162	R-1479 4'-Azidocytidine	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	R-1479 (4'-Azidocytidine) 是一种 RdRp 抑制剂，对于 HCV 亚基因组复制子系统中的 HCV RNA 复制，IC50 值为 1.28 μM。
T9249	ITMN4077	Antiviral	Immunology/Inflammation
	ITMN4077 对感染人类 HuH7 细胞的丙型肝炎病毒具有抗病毒活性，评估为抑制 HCV 亚基因组复制子复制，EC50 为 2.131μM。
T16088	MK-0608	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	MK-0608 是一种可口服的体外 HCV 复制抑制剂。在亚基因组复制子测定中，EC50值为 0.3 μM，EC90值为 1.3 μM。
T3334	Velpatasvir GS-5816,维帕他韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Velpatasvir (GS-5816) 是一种的 HCV NS5A 抑制剂。它也是 SARS-CoV 3CLpro 的抑制剂，IC50为 2.16 μM。
T4988	Boceprevir SCH 503034,EBP 520,波普瑞韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Boceprevir (SCH 503034) 是一种口服有效的选择性 HCV NS3 蛋白酶抑制剂。在酶试验中的 Ki 为 14 nM，在基于细胞的复制子试验中 EC90 为 350 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。
T7215	NM107 NM-107,2'-C-甲基胞嘧啶核苷,2'-C-Methylcytidine	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	NM107 (2'-C-Methylcytidine) 是一种具有广谱抗病毒活性的核糖核苷，是丙型肝炎病毒 NS5B 聚合酶的核苷抑制剂，在野生型复制子细胞中的 EC50 为 1.85 μM。
T6729	Lomibuvir VX-222,VCH-222	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Lomibuvir (VCH-222) (VX-222) 是丙型肝炎病毒 NS5B 聚合酶的一种非核苷变构抑制剂，Kd 值为 17 nM，已证明具有临床疗效。Lomibuvir 抑制 1b/Con1 型 HCV 亚基因组复制子，EC50为 5.2 nM。Lomibuvir 优先抑制延长的 RNA 合成，而非从头合成的 RNA。
T60531	2'-C-Methyladenosine	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	2'-C-Methyladenosine 是丙型肝炎病毒(HCV)复制的抑制剂，分离自肾棒状杆菌。2'-C-Methyladenosine 抑制 HCV 复制子和 NS5B 催化的 RNA 合成，IC50值分别为 0.3 μM 和 1.9 μM。2'-C-Methyladenosine 还对Leishmania guyanensis (Lgy)和Leishmania braziliensis中的 LRV1有抑制作用。
T38237	2′-O-Methylcytidine	Nucleoside Antimetabolite/Analog; HCV Protease	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	2'-O-Methylcytidine 是 2'-代核苷，可抑制 HCV 复制。它在体外抑制 NS5B 催化的 RNA 合成，其抑制方式是与底物核苷三磷酸竞争。
T64202	HCV-IN-40
	HCV-IN-39 (Compound 18a) 是一种有效的、口服具有活力的 hepatitis C virus (HCV) 核苷抑制剂，能够作用于 GT1a 复制子 (EC50: 0.259 μM)、GT1b 复制子 (EC50: 0.434 μM) 和 GT1b CES1 复制子 (EC50: 0.069 μM)。
T15631	JTK-853	Others	Others
	JTK-853 is a novel, non-nucleoside inhibitor of Hepatitis C Virus (HCV) polymerase. It also displays effective antiviral activity in HCV replicon cells (EC50s: 0.38 and 0.035 µM in genotype 1a H77 and 1b Con1 strains, respectively).
T12960	Sofosbuvir impurity E	Others	Others
	Sofosbuvir impurity E is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay,with potent anti-hepatitis C virus (HCV) activity.
T12955	Sofosbuvir D6 PSI-7977 D6,GS-7977 D6	Others	Others
	Sofosbuvir D6 is the deuterium labeled Sofosbuvir. Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
T12959	Sofosbuvir impurity D	Others	Others
	Sofosbuvir impurity D is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay,with potent anti-hepatitis C virus (HCV) activity.
T12954	Sofosbuvir 13CD3 GS-7977 13CD3,PSI-7977 13CD3	Others	Others
	Sofosbuvir 13CD3 is the deuterium labeled Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay, with potent anti-hepatitis C virus (HCV) activity.
T12958	Sofosbuvir impurity C	Others	Others
	Sofosbuvir impurity C is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay,with potent anti-hepatitis C virus (HCV) activity.
T12957	Sofosbuvir impurity B	Others	Others
	Sofosbuvir impurity B is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay, with potent anti-hepatitis C virus (HCV) activity.
T71085	BMS-824
	BMS-824 is a potent NS5A inhibitor. The 50% inhibition of HCV replicon replication for BMS-824 was approximately 5 nM, with a therapeutic index of >10,000. BMS-824 showed good specificity for HCV, as it was not active against several other RNA and DNA viruses.
T16715	Furaprofen 呋喃洛芬,R803	Others	Others
	Furaprofen is substantially more potent against genotype 1a and 1b replicons (EC50, ~30 nM) than against the genotype 2a replicon (EC50:1000 nM). Furaprofen is an effective HCV replication inhibitor.
T63593	Dasabuvir sodium
	Dasabuvir (ABT-333) sodium 是非核苷丙型肝炎病毒 (HCV) 聚合酶抑制剂。Dasabuvir sodium 对 HCV NS5B 基因编码的 RNA 依赖性 RNA 聚合酶 (RNA polymerase) 表现出抑制作用。Dasabuvir sodium 能够抑制基因型 1a (菌株 H77) 复制子 (EC50: 7.7 nM) 和 1b (菌株 Con1) 复制子 (EC50: 1.8 nM)。
T74070	NHC-triphosphate tetrasodium
	NHC-triphosphate tetrasodium 是 NHC 的活性胞内磷酸盐代谢物 (intracellular metabolite)，以三磷酸盐的形式存在。NHC-triphosphate tetrasodium 是病毒聚合酶 (viral polymerase) 的弱底物替代物，会被并入HCV 复制子 RNA 中。
T75241	Ledipasvir hydrochloride GS-5885 hydrochloride
	Ledipasvir (GS-5885) hydrochloride 是抗HCV NS5A 的高效抑制剂，对GT1a 和 GT1b 复制子抑制作用显著，其EC50值仅为34 pM 和 4 pM。此外，Ledipasvir hydrochloride 还能抑制 SARS-CoV 3CLpro， IC50 为1.62 μM。
T73814	cis-Lomibuvir
	cis-Lomibuvir (cis-VX-222) 是 Lomibuvir 的顺式异构体。Lomibuvir (VX-222) 是一种选择性的非核苷聚合酶抑制剂，靶向丙型肝炎病毒 NS5B 聚合酶 (RdRp) 的拇指口袋 2，Kd 为 17 nM。Lomibuvir 抑制 1b/Con1 型 HCV 亚基因组复制子，EC50为 5.2 nM。Lomibuvir 优先抑制延长的 RNA 合成，而非从头合成的 RNA。
T36881	NHC-diphosphate triammonium
	NHC-triphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form[1]. NHC-triphosphate triammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2]. In an intracellular metabolism assay, HCV replicon cells are treated with 10 μM 3H-labeled NHC, and intracellular nucleotide levels are determined after 1, 2 and 8 hours incubations. NHC is rapidly convered into the mono...

化合物

Cat.No: T9577

Target: HCV Protease

Inarigivir soproxil

Cat.No: T15573

Synonym: SB9200

Target: HCV Protease

Cat.No: T6229

Synonym: Daklinza,达卡他韦,EBP 883,达拉他韦,BMS-790052

Target: HCV Protease

Daclatasvir dihydrochloride

Cat.No: T1786

Synonym: BMS-790052 dihydrochloride,盐酸达拉他韦

Target: HCV Protease

Cat.No: T22142

Synonym: RO4948191,CDM-3008

Target: HCV Protease, HBV, JAK, IFNAR, STAT

Cat.No: TQ0162

Synonym: 4'-Azidocytidine

Target: HCV Protease

Cat.No: T9249

Target: Antiviral

Cat.No: T16088

Target: HCV Protease

Cat.No: T3334

Synonym: GS-5816,维帕他韦

Target: HCV Protease, SARS-CoV

Cat.No: T4988

Synonym: SCH 503034,EBP 520,波普瑞韦

Target: HCV Protease, SARS-CoV

Cat.No: T7215

Synonym: NM-107,2'-C-甲基胞嘧啶核苷,2'-C-Methylcytidine

Target: HCV Protease

Cat.No: T6729

Synonym: VX-222,VCH-222

Target: HCV Protease

2'-C-Methyladenosine

Cat.No: T60531

Target: HCV Protease

2′-O-Methylcytidine

Cat.No: T38237

Target: Nucleoside Antimetabolite/Analog, HCV Protease

Cat.No: T64202

Cat.No: T15631

Target: Others

Sofosbuvir impurity E

Cat.No: T12960

Target: Others

Cat.No: T12955

Synonym: PSI-7977 D6,GS-7977 D6

Target: Others

Sofosbuvir impurity D

Cat.No: T12959

Target: Others

Sofosbuvir 13CD3

Cat.No: T12954

Synonym: GS-7977 13CD3,PSI-7977 13CD3

Target: Others

Sofosbuvir impurity C

Cat.No: T12958

Target: Others

Sofosbuvir impurity B

Cat.No: T12957

Target: Others

Cat.No: T71085

Cat.No: T16715

Synonym: 呋喃洛芬,R803

Target: Others

Dasabuvir sodium

Cat.No: T63593

NHC-triphosphate tetrasodium

Cat.No: T74070

Ledipasvir hydrochloride

Cat.No: T75241

Synonym: GS-5885 hydrochloride

Cat.No: T73814

NHC-diphosphate triammonium

Cat.No: T36881

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