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2

抑制剂 & 化合物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T36923	CXCR2-IN-2 CXCR2-IN-2
	CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM[1]. CXCR2-IN-2 (compound 68) (1-10 mg/kg; p.o.; twice daily for 3 days) dose-dependently reduces neutrophil infiltration in vivo in ra...
T36443	(R,R)-CXCR2-IN-2 (R,R)-CXCR2-IN-2
	(R,R)-CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively[1]. [1]. Lu H, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61(6):2518-2532.

化合物

Cat.No: T36923

Synonym: CXCR2-IN-2

(R,R)-CXCR2-IN-2

Cat.No: T36443

Synonym: (R,R)-CXCR2-IN-2

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00006	GRO beta/CXCL2 Protein, Human, Recombinant GROb,MIP-2a,CINC-2a,GRO β/CXCL2,M...	Human	E. coli
	GRO beta/CXCL2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.9 kDa and the accession number is A0A024RDD9.
TMPJ-00011	CXCL2 Protein, Mouse, Recombinant Gro-beta,GRO β,GROB,mela...	Mouse	E. coli
	C-X-C motif chemokine 2 (CXCL2,MIP-2) belongs to the intercrine alpha (chemokine CxC) family. It was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. The expression of mouse MIP-2 is stimulated by endotoxin. The mouse MIP-2 shares approximately 63% aa sequence identity with murine KC, another mouse alpha chemokine, which is induced by PDGF. It has been suggested that mouse KC and MIP-2 are the homologs of the hum...
TMPY-00009	GRO beta/CXCL2 Protein, Rat, Recombinant chemokine (C-X-C motif) ligand 2,GRO β/CXC...	Rat	E. coli
	GRO beta/CXCL2 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.6 kDa and the accession number is A6KKD4.
TMPY-04789	GRO beta/CXCL2 Protein, Mouse, Recombinant (His) MIP-2a,chemokine (C-X-C motif) ligand 2,Scyb,MIP-2,Gro	Mouse	P. pastoris (Yeast)
	GRO beta/CXCL2 Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 9.2 kDa and the accession number is P10889.
TMPY-02064	GRO beta/CXCL2 Protein, Mouse, Recombinant (His & SUMO) Mip2,GRO β/CXCL2,chemokine (C-X-C motif) l...	Mouse	E. coli
	GRO beta/CXCL2 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with His and SUMO tag. The predicted molecular weight is 21.2 kDa and the accession number is P10889-1.

重组蛋白

GRO beta/CXCL2 Protein, Human, Recombinant

Cat.No: TMPY-00006

Species: Human

Expression System: E. coli

CXCL2 Protein, Mouse, Recombinant

Cat.No: TMPJ-00011

Species: Mouse

Expression System: E. coli

GRO beta/CXCL2 Protein, Rat, Recombinant

Cat.No: TMPY-00009

Species: Rat

Expression System: E. coli

GRO beta/CXCL2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04789

Species: Mouse

Expression System: P. pastoris (Yeast)

GRO beta/CXCL2 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPY-02064

Species: Mouse

Expression System: E. coli

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