Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T22748 |
DQP 1105
|
NMDAR | Neuroscience |
DQP 1105 是一种高效非竞争性NMDA 受体拮抗剂。DQP-1105 抑制含有 GluN2C (IC50:7.0 Μm) 和 GluN2D (IC50:2.7 Μm) 的受体 。 IC50值至少比重组 GluN2B-、GluN2A-、GluA1- 或 GluK2 受体低 50 倍。 | |||
T15407 |
GNE-0723
|
Others | Others |
GNE 0723 is an NMDAR brain permeable positive allosteric modulator (EC50: 21 nM for GluN2A; 7.4 and 6.2 μM for GluN2C and GluN2D, respectively). | |||
T24689 |
PYD-106
|
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PYD-106 is a GluN2C-selective Positive Allosteric Modulator of the NMDA Receptor. | |||
T15408 | GNE 5729 | Others | Others |
GNE 5729 is an NMDAR of brain permeable positive allosteric modulator (EC50: 37 nM for GluN2A; 4.7 and 9.5 μM for GluN2C and GluN2D, respectively). | |||
T24551 |
NSC339614 potassium
NSC 339614 potassium,NSC-339614 potassium,NSC339614 potassium salt |
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NSC339614 potassium is a selective GluN1/GluN2C and GluN1/GluN2D receptors potentiator. | |||
T61227 |
NAB-14
|
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NAB-14 is a powerful and selective chemical compound that acts as a non-competitive antagonist for GluN2C and GluN2D receptors. With an IC50 value of 580 nM for GluN1/GluN2D, NAB-14 demonstrates high potency. This compound exhibits a remarkable selectivity of more than 800-fold towards recombinant GluN2C and GluN2D when compared to GluN2A and GluN2B. Furthermore, NAB-14 possesses the ability to penetrate the blood-brain-barrier effectively [1]. | |||
T79611 |
DQP-26
|
iGluR | Membrane transporter/Ion channel; Neuroscience |
DQP-26,作为一种高效的NMDAR负变构调制剂,展现出对GluN2C和GluN2D亚单位具有显著的选择性,其IC50值分别仅为0.77 μM和0.44 μM。该化合物在针对NMDAR相关神经系统疾病的研究中显示出潜在应用价值。 | |||
T82528 | DQP-997-74 | ||
DQP-997-74(compound 2i)是一种针对NMDAR的选择性抑制剂,GluN2C/D的IC50分别为0.069 μM和0.035 μM,显示出良好的血脑屏障透过性。DQP为二氢喹啉-吡唑啉。该化合物能够在激动剂谷氨酸的作用下,表现出对高频兴奋性突触传递所驱动的超同步活动具有时间依赖性的增强抑制作用。在TSC诱导的癫痫小鼠模型中,DQP-997-74有效减少了发作次数,适用于NMDAR相关神经系统疾病的研究。 |