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Cat. No. Product Name Target Signaling Pathways
T3113 Foretinib

GSK089,EXEL-2880,GSK1363089,XL880

VEGFR; Tie-2; c-Met/HGFR Angiogenesis; Tyrosine Kinase/Adaptors
Foretinib (GSK1363089) 是多靶点酪氨酸激酶抑制剂,能够抑制 Met (IC50:0.4 nM) 和 KDR (IC50:0.9 nM)。
T71187 Foretinib phosphate

Foretinib phosphate is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers.

化合物

Foretinib
Cat.No: T3113
Synonym: GSK089,EXEL-2880,GSK1363089,XL880
Target: VEGFR, Tie-2, c-Met/HGFR
Foretinib phosphate
Cat.No: T71187
Synonym:
Target:
TargetMol Loading
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