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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T60074 GPCR agonist-2

4-(Cyclopropylamino)-3-nitrobenzoic acid

GPR Endocrinology/Hormones; GPCR/G Protein
GPCR agonist-2 (4-(Cyclopropylamino)-3-nitrobenzoic acid) 是人源 GPCR GPR109B 的激动剂。
T4186 AC-264613

AC264613

Protease-activated Receptor GPCR/G Protein
AC-264613 是一种选择性蛋白酶激活受体 (PAR-2) 激动剂,pEC50为 7.5。
T69953 MK-8666 Tris

MK-8666 Tris is a partial GPCR (G-protein-coupled receptor) agonist that is coordinated with the action of GPR40. GPR40, also known as free fatty acid (FFA) receptor 1 modulates fatty acid-induced insulin secretion in pancreatic beta cells and in intestinal enteroendocrine cells. Thus, MK-8666 Tris has been investigated for treatment of type 2 diabetes mellitus and has been shown to robustly lower glucose without negative effects.
T70468 MK-8666

MK-8666 is a partial GPCR (G-protein-coupled receptor) agonist that is coordinated with the action of GPR40. GPR40, also known as free fatty acid (FFA) receptor 1 modulates fatty acid-induced insulin secretion in pancreatic beta cells and in intestinal enteroendocrine cells. Thus, MK-8666 has been investigated for treatment of type 2 diabetes mellitus and has been shown to robustly lower glucose without negative effects.

化合物

GPCR agonist-2
Cat.No: T60074
Synonym: 4-(Cyclopropylamino)-3-nitrobenzoic acid
Target: GPR
AC-264613
Cat.No: T4186
Synonym: AC264613
Target: Protease-activated Receptor
MK-8666 Tris
Cat.No: T69953
Synonym:
Target:
MK-8666
Cat.No: T70468
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T14063 7α,25-Dihydroxycholesterol

7α,25-OHC

EBI2/GPR183; Endogenous Metabolite GPCR/G Protein; Metabolism
7α,25-Dihydroxycholesterol 是一种孤儿 GPCR 受体EBI2 (GPR183)的内源性配体和有效选择性激动剂。它对激活 EBI2 有很强的作用 (EC50=140 pM;Kd=450 pM)。它能够作为一种趋化因子,指导 B 细胞、T 细胞和树突状细胞的迁移。

天然产物

7α,25-Dihydroxycholesterol
Cat.No: T14063
Synonym: 7α,25-OHC
Target: EBI2/GPR183, Endogenous Metabolite
TargetMol Loading
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