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Cat. No. Product Name Target Signaling Pathways
T27621 Ipatasertib HCl

GDC0068,RG 7440,GDC 0068,RG-7440,GDC-0068,RG7440

Ipatasertib is an orally active, potent and selective Akt inhibitor with antitumor activity. Inhibition of Akt activity by Ipatasertib resulted in blockade of cell-cycle progression and reduced viability of cancer cell lines. Markers of Akt activation, in
T6252 Ipatasertib

GDC-0068,RG7440,帕他色替

Akt Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
Ipatasertib (GDC-0068) 是选择性的,ATP 竞争性的pan-Akt 抑制剂,能够抑制Akt1 (IC50:5 nM),Akt2 (IC50:18 nM),Akt3 (IC50:8 nM)。
T15374 Ipatasertib dihydrochloride

GDC-0068 dihydrochloride,RG-7440 dihydrochloride

Akt; PKA Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) 是ATP 竞争性的pan-Akt 选择性抑制剂,抑制Akt1,Akt2,Akt3,IC50分别为 5,18,8 nM。
T70552 Ipatasertib tosylate

Ipatasertib, also known as GDC0068, is an orally active, potent and selective Akt inhibitor. GDC-0068 blocked Akt signaling both in cultured human cancer cell lines and in tumor xenograft models. Inhibition of Akt activity by GDC-0068 resulted in blockade of cell-cycle progression and reduced viability of cancer cell lines. Markers of Akt activation, including high-basal phospho-Akt levels, PTEN loss, and PIK3CA kinase domain mutations, correlate with sensitivity to GDC-0068. In multiple tumor...

化合物

Ipatasertib HCl
Cat.No: T27621
Synonym: GDC0068,RG 7440,GDC 0068,RG-7440,GDC-0068,RG7440
Target:
Ipatasertib
Cat.No: T6252
Synonym: GDC-0068,RG7440,帕他色替
Target: Akt
Ipatasertib dihydrochloride
Cat.No: T15374
Synonym: GDC-0068 dihydrochloride,RG-7440 dihydrochloride
Target: Akt, PKA
Ipatasertib tosylate
Cat.No: T70552
Synonym:
Target:
TargetMol Loading
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