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Cat. No. Product Name Target Signaling Pathways
T15374 Ipatasertib dihydrochloride

GDC-0068 dihydrochloride,RG-7440 dihydrochloride

Akt; PKA Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) 是ATP 竞争性的pan-Akt 选择性抑制剂,抑制Akt1,Akt2,Akt3,IC50分别为 5,18,8 nM。
T6252 Ipatasertib

GDC-0068,RG7440,帕他色替

Akt Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
Ipatasertib (GDC-0068) 是选择性的,ATP 竞争性的pan-Akt 抑制剂,能够抑制Akt1 (IC50:5 nM),Akt2 (IC50:18 nM),Akt3 (IC50:8 nM)。
T27621 Ipatasertib HCl

GDC0068,RG 7440,GDC 0068,RG-7440,GDC-0068,RG7440

Ipatasertib is an orally active, potent and selective Akt inhibitor with antitumor activity. Inhibition of Akt activity by Ipatasertib resulted in blockade of cell-cycle progression and reduced viability of cancer cell lines. Markers of Akt activation, in
T70552 Ipatasertib tosylate

Ipatasertib, also known as GDC0068, is an orally active, potent and selective Akt inhibitor. GDC-0068 blocked Akt signaling both in cultured human cancer cell lines and in tumor xenograft models. Inhibition of Akt activity by GDC-0068 resulted in blockade of cell-cycle progression and reduced viability of cancer cell lines. Markers of Akt activation, including high-basal phospho-Akt levels, PTEN loss, and PIK3CA kinase domain mutations, correlate with sensitivity to GDC-0068. In multiple tumor...

化合物

Ipatasertib dihydrochloride
Cat.No: T15374
Synonym: GDC-0068 dihydrochloride,RG-7440 dihydrochloride
Target: Akt, PKA
Ipatasertib
Cat.No: T6252
Synonym: GDC-0068,RG7440,帕他色替
Target: Akt
Ipatasertib HCl
Cat.No: T27621
Synonym: GDC0068,RG 7440,GDC 0068,RG-7440,GDC-0068,RG7440
Target:
Ipatasertib tosylate
Cat.No: T70552
Synonym:
Target:
TargetMol Loading
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