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Cat. No. | Product Name | Target | Signaling Pathways |
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T74893 | EGCG-4″-sulfate | ||
EGCG-4″-sulfate,作为绿茶中的主要多酚成分,具有抑制细胞增殖和诱导细胞凋亡的功能。它通过抑制谷氨酸脱氢酶1/2(GDH1/2, GLUD1/2)活性,发挥作用。此外,EGCG-4″-sulfate在对抗结直肠癌、髓性白血病、甲状腺癌等多种癌症中显示出显著的抗癌、抗氧化和抗炎效果[2]。 | |||
T72621 |
GCGR antagonist 2
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GCGR antagonist2 是一种呋喃-2-碳酰肼化合物,是具有口服活性的胰高血糖素受体拮抗剂。GCGR antagonist2 与 hGluR 结合的 Kd 值为 2.3 nM,抑制大鼠受体的 IC50值为 0.43 nM。GCGR antagonist2 可抑制胰高血糖素刺激的糖原分解。 | |||
T73707 |
Insulin Detemir
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InsulinDetemir 是一种人工胰岛素,具有控制血糖水平的作用。InsulinDetemir 通过激活 Akt 和细胞外信号调节激酶 (ERK) 依赖的-cat 和 CREB 信号通路,促进 Gcg 表达,从而刺激 GLP-1的分泌。地特胰岛素可用于 2 型糖尿病的研究。 | |||
T80149 |
GRPP (human)
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GRPP (human)为含有30个氨基酸的Gcg衍生肽。该化合物能引起血浆胰岛素的轻微上升及血浆胰高血糖素的轻微降低,但不会影响大鼠胰岛内的胰岛素分泌。 | |||
T81214 |
SAR441255
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SAR441255为高效单分子肽GLP-1/GIP/GCG受体激动剂,能平衡激活三种靶受体,表现出高效力。此外,SAR441255对糖尿病肥胖猴子具有显著的急性血糖调节效果。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T8160 |
EGCG Octaacetate
乙酰化表没食子儿茶素没食子酸酯,乙酰化EGCG |
Others; Antibacterial | Microbiology/Virology; Others |
EGCG Octaacetate 是表没食子儿茶素没食子酸酯的前药,对革兰氏阳性菌和革兰氏阴性菌有潜在抗菌可能。它可下调 PI3K/Akt/NFκB 磷酸化和 p65 乙酰化来降低促炎介质水平,减少小鼠结肠炎引起的结肠癌。 |
Cat. No. | Product Name | Species | Expression System |
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TMPJ-00742 |
GCG Protein, Human, Recombinant (His)
Glicentin,GRPP,GLP-2,Glucagon-Like Peptide 1,OXM,Glucagon,GL... |
Human | HEK293 Cells |
Glucagon is a secreted protein and belongs to the glucagon family. Glucagon can be cleved into 8 chains, playing an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon can regulates blood glucose by decreasing glycolysis and increasing gluconeogenesis. In addition, Glucagon is involved in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin.... | |||
TMPH-01382 |
GCGR Protein, Human, Recombinant (E. coli, His & Myc)
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Human | E. coli |
GCGR Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 20.5 kDa and the accession number is P47871. | |||
TMPH-01077 |
UGCG Protein, Human, Recombinant (His)
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Human | E. coli |
UGCG Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 47.7 kDa and the accession number is Q16739. | |||
TMPH-01383 |
GCGR Protein, Human, Recombinant (His & Myc)
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Human | HEK293 Cells |
GCGR Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 18.1 kDa and the accession number is P47871. | |||
TMPH-02675 |
GCGR Protein, Mouse, Recombinant (GST)
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Mouse | E. coli |
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. ... | |||
TMPH-02312 |
Wilms tumor protein/WT1 Protein, Human, Recombinant (His & SUMO)
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Human | E. coli |
Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may b... |