34
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Cat. No. | Product Name | Target | Signaling Pathways |
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T78562 |
FX-06
Fibrin-derived peptide Bβ15-42 |
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FX-06 (Fibrin-derived peptide Bβ15-42)为纤维蛋白Bbeta链衍生的肽类化合物。通过与VE-cadherin结合并阻断白细胞的迁移,FX-06激活了以VE-cadherin为中心的信号通路。该化合物主要应用于缺血/再灌注损伤和登革热休克综合征(DSS)的相关研究。 | |||
T4502 |
BISMUTH SUBGALLATE
次没食子酸铋,Dermatol Puder,Bismuth Gallate |
Others | Others |
Bismuth subgallate (Dermatol Puder) 是一种止血剂,可作用于凝血因子 XII ,促使凝血级联的激活,改善纤维蛋白凝块的早期形成。 | |||
T19786 |
Hematin
Ferrihemate,Ferriheme hydroxide,Ferriheme,Ferrihemic acid,羟高铁血红素 |
Others | Others |
Hematin (Ferrihemic acid) 是含铁卟啉,可以结合止血蛋白诱导其失活,降低凝血因子的活性以及阻碍纤维蛋白凝块的溶解。它可用于研究急性卟啉症和癌症。 | |||
TP1060 |
GPRP acetate (67869-62-9 free base)
Pefabloc FG,Pefa 6003,GPRP acetate |
Others | Others |
GPRP acetate (Pefabloc FG) 是纤维蛋白聚合抑制剂,可抑制纤维蛋白原与血小板膜糖蛋白 Ⅱb/IIIa 复合物(糖蛋白 IIb/IIIa 受体)之间的相互作用。 | |||
TP1143L |
Fibrinopeptide A, human acetate
Fibrinopeptide A, human acetate(25422-31-5 free base),Human fibrinopeptide A acetate |
Others | Others |
Fibrinopeptide A, human acetate (Human fibrinopeptide A acetate)(25422-31-5 free base) 是一种 16 个残基的短多肽,由凝血酶从纤维蛋白原上切割下来。纤维蛋白肽 A (FPA) 由纤维蛋白原蛋白的 N 末端 Aα 区域在被凝血酶切割后产生。 | |||
TP1736L |
Fibrinogen-Binding Peptide 137235-80-4(fb-acetate)
|
Others | Others |
Fibrinogen-Binding Peptide 137235-80-4(fb-acetate) 是纤维蛋白原受体上玻连蛋白结合位点的推定肽模拟物。它结合纤维蛋白原并抑制血小板与纤维蛋白原的粘附和血小板聚集,还抑制血小板与玻连蛋白的粘附 | |||
TP1163 |
Fibrinopeptide B, human
FPB,human |
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Fibrinopeptide B (FPB) is produced during the cleavage of fibrinogen, by thrombin, to fibrin monomer. | |||
T78367 |
Fibrinogen (Bovine)
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Fibrinogen (Bovine)为特异性蛋白质水解酶,通过凝血酶激活过程组装成纤维蛋白凝块。 | |||
TP1142 |
Fibrinopeptide A, human TFA
Human fibrinopeptide A TFA |
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Fibrinopeptide A, human is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH2-termini of the Aα chain.The conversion of monomeric fibrinogen into polymeric fibrin is mediated by thrombin, which b | |||
TP1736 |
Fibrinogen-Binding Peptide
|
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Fibrinogen-Binding Peptide (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen, a soluble plasma protein, is a cofactor in platelet activation. It is converted | |||
T80682 |
γ-Fibrinogen 377-395 TFA
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γ-Fibrinogen377-395 TFA 是纤维蛋白原衍生抑制肽,具有纤维蛋白原表位特性。该化合物能在体外抑制小胶质细胞激活、阻断纤维蛋白与Mac-1相互作用,并在小鼠体内抑制实验性自身免疫性脑脊髓炎(EAE)。该肽适用于多发性硬化症(MS)及其他血脑屏障损伤和小胶质细胞激活相关的神经炎症疾病研究。 | |||
T80683 |
γ-Fibrinogen 377-395
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γ-Fibrinogen377-395是一种衍自纤维蛋白原的抑制性肽段,也被认为是纤维蛋白原的表位之一。它能在体外抑制小胶质细胞的激活并阻断纤维蛋白与Mac-1的交互作用;此外,在小鼠体内能够抑制实验性自身免疫性脑脊髓炎(EAE)的发展。因此,γ-Fibrinogen377-395对于多发性硬化症(MS)以及其他与血脑屏障损伤和小胶质细胞活化相关的神经炎症性疾病的研究具有潜在的应用价值。 | |||
TP1143 |
Fibrinopeptide A, human
Human fibrinopeptide A |
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Fibrinopeptide A, human is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A (FPA) is produced from the N-terminal Aα region of fibrinogen protein, on cleavage by thrombin. | |||
TP1778 |
Fibrinogen Binding Inhibitor Peptide
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Fibrinogen Binding Inhibitor Peptide, a synthetic dodecapeptide, represents the specific platelet receptor recognition site of the human fibrinogen g-chain (residues 400-411). | |||
TP1864 |
[Glu1]-Fibrinopeptide B
[Glu1]-纤维蛋白肽B |
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[Glu1]-Fibrinopeptide B, a derivative of fibrinopeptide B amino acid residues 1-14, originates from human fibrinopeptide B (hFpB). hFpB is a proteolytic cleavage product of the fibrinogen B beta-chain, specifically generated by thrombin, which plays a significant role in activating neutrophils (PMN), monocytes, and fibroblasts. | |||
TP1162 |
Fibrinopeptide B, human TFA (36204-23-6 free base)
FPB,human TFA,Fibrinopeptide B, human TFA |
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FibrinopeptideB,human is a 14-amino acid polypeptide released from the amino terminus of the fibrinogen segment. | |||
T78215 |
Dechloro Rivaroxaban
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Factor Xa; Others | Metabolism; Others |
Dechloro Rivaroxaban 是一种具有口服活性和高选择性的 Factor Xa 抑制剂。Dechloro Rivaroxaban 对人体内游离 FXa 的抑制作用显著。Dechloro Rivaroxaban 对凝血酶原以及纤维蛋白相关的 FXa 活性也有抑制效果。 | |||
T1736 |
Apixaban
阿哌沙班,BMS-562247-01 |
Factor Xa | Metabolism |
Apixaban (BMS-562247-01) 是一种高度选择性,可逆的、口服具有活力的凝血因子 Xa (Factor Xa) 抑制剂,抑制人和兔凝血因子 Xa 的 Ki 分别为 0.08 nM 和 0.17 nM。它可以用于研究各种血栓栓塞疾病。 | |||
T1184 |
Rivaroxaban
BAY 59-7939,利伐沙班 |
Factor Xa; Thrombin | Metabolism; Proteases/Proteasome |
Rivaroxaban (BAY 59-7939) 是高效选择性的凝血因子 Xa (FXa) 直接抑制剂,IC50=0.7 nM,Ki 为 0.4 nM。 | |||
T38736 | Nattokinase | ||
Nattokinase is a powerful fibrinolytic enzyme that effectively hydrolyzes fibrin and plasmin substrate, leading to the breakdown of blood clots. Its efficacy renders it valuable for cardiovascular disease studies. | |||
TP1555 |
Fibronectin Active Fragment Control
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Fibronectin is a high-molecular weight (~440kDa) extracellular matrix glycoprotein that binds to membrane-spanning receptor proteins called integrins.In addition to integrins, fibronectin also binds extracellular matrix components such as collagen, fibrin | |||
T35583 |
Hirudin (54-65; non-sulfated) (trifluoroacetate salt)
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Hirudin (54-65; non-sulfated) is a desulfated peptide fragment of hirudin, an anticoagulant produced byH. medicinalis.1It inhibits fibrin clot formation induced by isolated bovine thrombin with an IC50value of 3.7 μM.2 1.Niehrs, C., Huttner, W.B., Carvallo, D., et al.Conversion of recombinant hirudin to the natural form by in vitro tyrosine sulfation. Differential substrate specificities of leech and bovine tyrosylprotein sulfotransferasesJ. Biol. Chem.265(16)9314-9318(1990) 2.Payne, M.H., Krste... | |||
T82201 |
H-Gly-Pro-Arg-Pro-NH2
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H-Gly-Pro-Arg-Pro-NH2 是模拟纤维蛋白原(N-末端Gly-Pro-Arg区域)的四肽,具有抑制纤维蛋白聚合的功能。 | |||
T62961 | ZK824859 hydrochloride | ||
ZK824859 hydrochloride 是一种选择性的、口服具有活力的尿激酶型纤溶酶原激活剂 (uPA) 抑制剂。ZK824859 hydrochloride 对人 uPA,tPA 和纤溶酶的 IC50 值分别为 79 nM,1580 nM 和 1330 nM。 | |||
T26657 |
AR-H067637
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AR-H067637 is a rapid-binding, reversible and potent (inhibition constant K(i) = 2-4 nM), competitive inhibitor of thrombin, as well as of thrombin bound to fibrin (clot-bound thrombin) or to thrombomodulin. The total amount of free thrombin generated in | |||
T25976 |
Ppack HCl
Ppack dihydrochloride,Fprmecl, dihydrochloride |
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Ppack HCl is a peptide derivative that irreversibly and specifically suppresses thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki: 0.24 nM). It has been utilized as an anticoagulant (100 μM) and to stud | |||
T80119 |
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
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Thrombin | Proteases/Proteasome |
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) 是一种具有高亲和力的Hirugen类肽,其与凝血酶的KD值小于100 nM。作为抗血栓剂,它能有效抑制凝血酶诱导的纤维蛋白凝块生成,其IC50值为0.087 μM。 | |||
T25977 |
Ppack trifluoroacetate
Ppack trifluoroacetate salt |
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Ppack trifluoroacetate is a peptide derivative that irreversibly and specifically suppresses thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki: 0.24 nM). It has been utilized as an anticoagulant (100 μM | |||
T82286 |
Glycylglycylcysteine
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Glycylglycylcysteine是一种TAFI抑制剂,其Ki值0.99μM,IC50值为9.4μM,在TAFI底物测定中有效性得以体现。TAFI为一种碱性羧肽酶,通过裂解部分降解纤维蛋白末端的赖氨酸,起到抑制纤维蛋白溶解的功能。 | |||
T62846 | Freselestat quarterhydrate | ||
Freselestat quarterhydrate (ONO-6818 quarterhydrate) 是一种有效的、口服具有活力的嗜中性粒细胞弹性蛋白酶 (neutrophil elastase) 抑制剂 (Ki: 12.2 nM)。Freselestat quarterhydrate 对其他蛋白酶(例如胰蛋白酶,蛋白酶3,胰弹性蛋白酶,凝血酶,纤溶酶,胶原酶,组织蛋白酶G 和鼠巨噬细胞弹性蛋白酶)的活性低 100 倍以上,表现出有效的抗炎作用。 | |||
TP2234 |
coagulation factor II (thrombin) B chain fragment [Homo sapiens]
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Others | Others |
Thrombin is a "trypsin-like" serine protease that is encoded by the F2 gene in humans. Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). Thrombin in turn acts as a serine protease that converts soluble | |||
T78018 |
Plasminogen
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Plasminogen是一种可由尿激酶血浆蛋白原激活剂(uPA)或组织血浆蛋白原激活剂(tPA)裂解激活的分泌性蛋白,生成血浆蛋白,该酶可以广泛裂解纤维蛋白及其他ECM成分。作为促炎调节剂,Plasminogen能促进急性及糖尿病相关伤口愈合。该蛋白在伤口愈合、炎症和低纤溶酶原血症的研究中有重要应用。 | |||
T83663 |
Mn(III) Protoporphyrin IX Chloride
Manganese(III) Protoporphyrin IX Chloride |
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Mn(III) protoporphyrin IX chloride是一种金属卟啉,当浓度为10 µM时,能在鸡胚肝细胞中诱导δ-氨基酮戊二酸合成酶和血红素加氧酶(HO)基因的mRNA表达,这些酶分别催化血红素生物合成和降解的限速步骤。Mn(III) protoporphyrin IX chloride含纳米仿生物已被用于体外纤维蛋白凝块的磁共振成像(MRI)研究。此外,它还被用于Mn(III) protoporphyrin IX-6(7)-甘氨酰-甘氨酰-L-组氨酸甲酯(MnGGH)的合成,MnGGH是一种具有微过氧化物酶活性的金属卟啉衍生物。 | |||
T36225 |
N-p-Tosyl-Gly-Pro-Lys-pNA (acetate)
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N-p-Tosyl-Gly-Pro-Lys-pNA is a colorimetric substrate for plasmin.1,2,3Plasmin binds and hydrolyzes N-p-tosyl-Gly-Pro-Lys-pNA to releasep-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of plasmin activity. 1.Jespersen, J., Gram, J., and Astrup, T.The autodigestion of human plasmin follows a bimolecular mode of reaction subject to product inhibitionThromb. Res.41(3)395-404(1986) 2.Kim, S.H., and Choi, N.S.Electrophoretic analysis of protease inhibitor... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T13693 |
Fibrin
|
Others | Others |
Fibrin 是血凝块的主要成分,为一种不溶性蛋白质,对凝血过程至关重要。这种蛋白质从牛血中分离出来,特别是在出血时合成。 | |||
T3793 |
(20R)-Ginsenoside Rh1
20(R)-Ginsenoside Rh1,人参皂苷 R-RH1,人参皂苷R-RH1 |
Others | Others |
(20R)-Ginsenoside Rh1 (20(R)-Ginsenoside Rh1) 是 Ginsenoside Rh1 的 R 型异构体,分离自 Panax Ginseng 中,能够阻碍凝血酶诱导的纤维蛋白原向纤维蛋白的转化。 |