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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T70991 Efrapeptin F

Efrapeptin F is a metabolite of entomogenous fungi in the genus Tolypocladium that acts as a mitochondrial complex V inhibitor. It has been shown to express preferential cytotoxicity to nutrient-deprived tumor cells compared with nutrient-sufficient tumor cells.
T79331 Antioxidant agent-13

Xanthine Oxidase Metabolism
Antioxidant agent-13(Compound 5f)为一种效能显著的抗氧化剂,其抑制DPPH和FRAP的IC50值分别为80.33 μM和85.69 μM;同时,Antioxidant agent-13对LOX和XO酶的抑制作用亦强,对应IC50值为16.85 μM及23.01 μM。
T37151 NVS-CECR2-1

NVS-CECR2-1

NVS-CECR2-1 is a potent inhibitor of CECR2 (cat eye syndrome chromosome region, candidate 2), a component of chromatin complexes that regulate gene expression controlling development. It binds CECR2 with high affinity (IC50 = 0.047 μM by Alpha screen, Kd = 0.80 μM by ITC). NVS-CECR2-1 demonstrates no crossreactivity in a panel of 48 bromodomains and has no major activity in kinase, protease, and receptor panels. It shows robust activity in cells by FRAP assay, due to its slow off-rate, and has n...
T30304 BAY-850 HCl

BAY-850,BAY850,BAY 850

BAY-850 is a chemical probe for the bromine domain of Atad2A. It replaces acetylated H4 peptides from the bromine domain of Atad2. AY-850 shows superior selectivity to all other bromine domains (not hit in 10 μm Bromoscan). Full-length ATAD2 was replaced

化合物

Efrapeptin F
Cat.No: T70991
Synonym:
Target:
Antioxidant agent-13
Cat.No: T79331
Synonym:
Target: Xanthine Oxidase
NVS-CECR2-1
Cat.No: T37151
Synonym: NVS-CECR2-1
Target:
BAY-850 HCl
Cat.No: T30304
Synonym: BAY-850,BAY850,BAY 850
Target:
Cat. No. Product Name Target Signaling Pathways
TN3469 Aucuparin

2,6-dimethoxy-4-phenylphenol

NADPH-oxidase Immunology/Inflammation
Aucuparin (2,6-dimethoxy-4-phenylphenol) 是一种植物抗菌素,具有抗炎活性。 在博来霉素 (BLM) 诱导的肺纤维化小鼠模型中,Aucuparin 抑制肺纤维化。 在经ABTS 和FRAP 测定显示出明显的清除活性。 Aucuparin 对fmlp 诱导的人中性粒细胞产生超氧化物具有明显的抑制作用,其IC50为17.0μM。

天然产物

Aucuparin
Cat.No: TN3469
Synonym: 2,6-dimethoxy-4-phenylphenol
Target: NADPH-oxidase
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