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4

抑制剂 & 化合物

1

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T70991	Efrapeptin F
	Efrapeptin F is a metabolite of entomogenous fungi in the genus Tolypocladium that acts as a mitochondrial complex V inhibitor. It has been shown to express preferential cytotoxicity to nutrient-deprived tumor cells compared with nutrient-sufficient tumor cells.
T79331	Antioxidant agent-13	Xanthine Oxidase	Metabolism
	Antioxidant agent-13（Compound 5f）为一种效能显著的抗氧化剂，其抑制DPPH和FRAP的IC50值分别为80.33 μM和85.69 μM；同时，Antioxidant agent-13对LOX和XO酶的抑制作用亦强，对应IC50值为16.85 μM及23.01 μM。
T37151	NVS-CECR2-1 NVS-CECR2-1
	NVS-CECR2-1 is a potent inhibitor of CECR2 (cat eye syndrome chromosome region, candidate 2), a component of chromatin complexes that regulate gene expression controlling development. It binds CECR2 with high affinity (IC50 = 0.047 μM by Alpha screen, Kd = 0.80 μM by ITC). NVS-CECR2-1 demonstrates no crossreactivity in a panel of 48 bromodomains and has no major activity in kinase, protease, and receptor panels. It shows robust activity in cells by FRAP assay, due to its slow off-rate, and has n...
T30304	BAY-850 HCl BAY-850,BAY850,BAY 850
	BAY-850 is a chemical probe for the bromine domain of Atad2A. It replaces acetylated H4 peptides from the bromine domain of Atad2. AY-850 shows superior selectivity to all other bromine domains (not hit in 10 μm Bromoscan). Full-length ATAD2 was replaced

化合物

Cat.No: T70991

Antioxidant agent-13

Cat.No: T79331

Target: Xanthine Oxidase

Cat.No: T37151

Synonym: NVS-CECR2-1

Cat.No: T30304

Synonym: BAY-850,BAY850,BAY 850

Cat. No.	Product Name	Target	Signaling Pathways
TN3469	Aucuparin 2,6-dimethoxy-4-phenylphenol	NADPH-oxidase	Immunology/Inflammation
	Aucuparin (2,6-dimethoxy-4-phenylphenol) 是一种植物抗菌素，具有抗炎活性。在博来霉素 (BLM) 诱导的肺纤维化小鼠模型中，Aucuparin 抑制肺纤维化。在经ABTS 和FRAP 测定显示出明显的清除活性。 Aucuparin 对fmlp 诱导的人中性粒细胞产生超氧化物具有明显的抑制作用，其IC50为17.0μM。

天然产物

Cat.No: TN3469

Synonym: 2,6-dimethoxy-4-phenylphenol

Target: NADPH-oxidase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02672	Prostatic Acid Phosphatase Protein, Mouse, Recombinant (His) 5'-NT,9.104100899-104272570.1,Ppal,A030005E02Rik,PAP,Lap,aci...	Mouse	HEK293 Cells
	Prostatic Acid Phosphatase Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42 kDa and the accession number is Q8CE08-1.
TMPY-01657	SUV420H2 Protein, Human, Recombinant (His & GST) suppressor of variegation 4-20 homolog 2 (Drosophila),KMT5C	Human	E. coli
	Histone-lysine N-methyltransferase SUV42H2, also known as Suppressor of variegation 4-2 homolog 2, Su(var)4-2 homolog 2, Lysine N-methyltransferase 5C, SUV42H2 and KMT5C, is nucleus protein that belongs to the histone-lysine methyltransferase family and Suvar4-2 subfamily. SUV42H2 is a histone methyltransferase that specifically trimethylates 'Lys-2' of histone H4. H4 'Lys-2' trimethylation represents a specific tag for epigenetic transcriptional repression. SUV42H2 mainly functions in pericentr...

重组蛋白

Prostatic Acid Phosphatase Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02672

Species: Mouse

Expression System: HEK293 Cells

SUV420H2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-01657

Species: Human

Expression System: E. coli

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