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Targets Recommended: Antifolate

2

抑制剂 & 化合物

13

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T76766 Mirvetuximab

M9346A

Antifolate Cell Cycle/Checkpoint
Mirvetuximab (M9346A) 是一种新型叶酸受体α (FRα) 靶向 anti-FOLR1 (folate receptor 1) 的单克隆抗体。Mirvetuximab soravtansine 常与铂类化合物或与其他化合物偶联成为抗体-药物偶联物用来治疗卵巢癌和其他 FRα 阳性的癌症。
T77825 Mirvetuximab soravtansine

IMGN853

Mirvetuximab soravtansine (IMGN853)是一种抗体药物偶联物(ADC),包含与人源化单克隆抗体M9346A共价连接的细胞毒素maytansoid DM4。该药物特异性地结合于叶酸受体1 (FOLR1),显示出抑制细胞生长和增强DNA损伤的抗增殖效果。

化合物

Mirvetuximab
Cat.No: T76766
Synonym: M9346A
Target: Antifolate
Mirvetuximab soravtansine
Cat.No: T77825
Synonym: IMGN853
Target:
Cat. No. Product Name Species Expression System
TMPJ-00147 FOLR1 Protein, Human, Recombinant (hFc)

Folate receptor 1,Folate receptor,Folate receptor a...

Human HEK293 Cells
FOLR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-75 kDa and the accession number is P15328.
TMPY-01815 FOLR1 Protein, Human, Recombinant (His)

FBP,Folate Binding Protein,folate receptor 1 (adult...

Human HEK293 Cells
FOLR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is A0A024R5H1.
TMPY-01803 FOLR1 Protein, Mouse, Recombinant (His)

folate receptor 1 (adult),Folbp1,FBP1<...

Mouse HEK293 Cells
FOLR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is P35846.
TMPY-06022 FOLR1 Protein, Cynomolgus, Rhesus, Recombinant (His)

folate receptor 1 (adult)

Cynomolgus,Rhesus HEK293 Cells
FOLR1 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is A0A2K5UR19&NP_001181576.1.
TMPJ-00148 FOLR1 Protein, Rhesus macaque, Recombinant (His)

FR-alpha,Adult folate-binding protein,Ovarian tumor-associat...

Rhesus HEK293 Cells
FOLR1 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 28-38 kDa and the accession number is F7BP60.
TMPK-00150 FOLR1 Protein, Human, Recombinant (His & Avi)

Folate receptor 1,Folbp1,Folate receptor a...

Human HEK293 Cells
Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into t...
TMPY-02417 FOLR1 Protein, Canine, Recombinant (hFc)

folate receptor 1 (adult)

Canine HEK293 Cells
FOLR1 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.7 kDa and the accession number is A0A8C0Z2T7.
TMPY-00622 FOLR1 Protein, Canine, Recombinant (His)

folate receptor 1 (adult)

Canine HEK293 Cells
FOLR1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.4 kDa and the accession number is A0A8C0Z2T7.
TMPY-00543 FOLR1 Protein, Rat, Recombinant (His)

folate receptor 1 (adult)

Rat HEK293 Cells
FOLR1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.7 kDa and the accession number is G3V8M6.
TMPY-04128 FOLR1 Protein, Rat, Recombinant (hFc)

folate receptor 1 (adult)

Rat HEK293 Cells
FOLR1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.9 kDa and the accession number is G3V8M6.
TMPY-06929 FOLR1 Protein, Human, Recombinant (His & Avi), Biotinylated

Folate Binding Protein,folate receptor 1 (adult),

Human HEK293 Cells
FOLR1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 27.83 kDa and the accession number is NP_057937.1.
TMPY-06928 FOLR1 Protein, Human, Recombinant (hFc & Avi), Biotinylated

FOLR,Folate Binding Protein,folate receptor 1

Human HEK293 Cells
FOLR1 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 53.11 kDa and the accession number is NP_057937.1.
TMPY-01280 FOLR2 Protein, Human, Recombinant (His)

FBP,β-HFR,FR-P3,BETA-HFR,folate receptor 2 (fetal),FR-BETA,F...

Human HEK293 Cells
Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant tissues. Members of the Folate receptor family members (FOLRs) have a high affinity for folic acid and for several reduced folic acid derivatives. They mediate the delivery of 5-methyltetrahydrofolate to the interior of, out of within, or between cells in a process known as potoc...

重组蛋白

FOLR1 Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-00147
Species: Human
Expression System: HEK293 Cells
FOLR1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01815
Species: Human
Expression System: HEK293 Cells
FOLR1 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01803
Species: Mouse
Expression System: HEK293 Cells
FOLR1 Protein, Cynomolgus, Rhesus, Recombinant (His)
Cat.No: TMPY-06022
Species: Cynomolgus,Rhesus
Expression System: HEK293 Cells
FOLR1 Protein, Rhesus macaque, Recombinant (His)
Cat.No: TMPJ-00148
Species: Rhesus
Expression System: HEK293 Cells
FOLR1 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00150
Species: Human
Expression System: HEK293 Cells
FOLR1 Protein, Canine, Recombinant (hFc)
Cat.No: TMPY-02417
Species: Canine
Expression System: HEK293 Cells
FOLR1 Protein, Canine, Recombinant (His)
Cat.No: TMPY-00622
Species: Canine
Expression System: HEK293 Cells
FOLR1 Protein, Rat, Recombinant (His)
Cat.No: TMPY-00543
Species: Rat
Expression System: HEK293 Cells
FOLR1 Protein, Rat, Recombinant (hFc)
Cat.No: TMPY-04128
Species: Rat
Expression System: HEK293 Cells
FOLR1 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-06929
Species: Human
Expression System: HEK293 Cells
FOLR1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Cat.No: TMPY-06928
Species: Human
Expression System: HEK293 Cells
FOLR2 Protein, Human, Recombinant (His)
Cat.No: TMPY-01280
Species: Human
Expression System: HEK293 Cells
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