3
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T32462 |
L 683519
L683519,13-Desmethyl FK 506,L-683519 |
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L 683519 is one of the Tacrolimus impurities with immunosuppressant and could restrain the activity of FK-506 binding protein. | |||
T32465 |
L 685818
L 685,818,L685,818,L685818,L-685,818,L-685818 |
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L 685818 is the C18-hydroxy, C21-ethyl of FK-506 analog. | |||
T76622 |
Suc-Ala-Leu-Pro-Phe-pNA
|
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Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA) 是一种 FK-506 结合蛋白 (FKBP) 的底物。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T20879 |
Tacrolimus monohydrate
FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506 |
Phosphatase; Others; Antibacterial; Antibiotic; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Others |
Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物,它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶,从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。 | |||
T2144 |
Tacrolimus
他克莫司,Fujimycin,FK506,FR900506 |
Phosphatase; Others; Antibacterial; Antibiotic; mTOR; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling |
Tacrolimus (Fujimycin) 可与 FKBP12 结合形成高亲和力复合物 (Ki: 0.2 nM),抑制钙/钙调蛋白依赖性蛋白磷酸酶的活性。 |