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Cat. No. Product Name Target Signaling Pathways
T3560 Desmethylanethol trithione

ADT-OH

VEGFR; Akt Angiogenesis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
Desmethylanethol trithione (ADT-OH) 是合成硫化氢的供体。它利用上调 FADD 诱导细胞凋亡,并对体内黑色素瘤的形成具有一定的抑制作用,可用于研究癌症疾病。
T9095 Necrostatin-34

2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4

RIP kinase Apoptosis; NF-κB
Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) 是一种 RIPK1 激酶抑制剂,通过在激酶结构域中占据一个独特的结合口袋,将 RIPK1 激酶稳定在非活性构象中。
T11259 FadD32 Inhibitor-1

Others Others
FadD32 inhibitor -1 has anti-tuberculosis activity and is an effective FadD32 inhibitor.
T37558 Necrostatin-5

Nec-5

RIP kinase; Necroptosis Apoptosis; NF-κB
Necrostatin-5 (Nec-5)是一种RIP1激酶的选择性抑制剂,也是一种细胞坏死抑制剂,可防止TNF-α处理的fadd 缺陷Jurkat 细胞死亡,EC50值为240 nM。
T12203L Necrostatin 2

Others Others
Necrostatin 2 is an effective necroptosis inhibitor. Necrostatin 2 is also a RIPK1 inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM.

化合物

Desmethylanethol trithione
Cat.No: T3560
Synonym: ADT-OH
Target: VEGFR, Akt
Necrostatin-34
Cat.No: T9095
Synonym: 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4
Target: RIP kinase
FadD32 Inhibitor-1
Cat.No: T11259
Synonym:
Target: Others
Necrostatin-5
Cat.No: T37558
Synonym: Nec-5
Target: RIP kinase, Necroptosis
Necrostatin 2
Cat.No: T12203L
Synonym:
Target: Others
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