Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3560 |
Desmethylanethol trithione
ADT-OH |
VEGFR; Akt | Angiogenesis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Desmethylanethol trithione (ADT-OH) 是合成硫化氢的供体。它利用上调 FADD 诱导细胞凋亡,并对体内黑色素瘤的形成具有一定的抑制作用,可用于研究癌症疾病。 | |||
T9095 |
Necrostatin-34
2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4 |
RIP kinase | Apoptosis; NF-κB |
Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) 是一种 RIPK1 激酶抑制剂,通过在激酶结构域中占据一个独特的结合口袋,将 RIPK1 激酶稳定在非活性构象中。 | |||
T11259 |
FadD32 Inhibitor-1
|
Others | Others |
FadD32 inhibitor -1 has anti-tuberculosis activity and is an effective FadD32 inhibitor. | |||
T37558 |
Necrostatin-5
Nec-5 |
RIP kinase; Necroptosis | Apoptosis; NF-κB |
Necrostatin-5 (Nec-5)是一种RIP1激酶的选择性抑制剂,也是一种细胞坏死抑制剂,可防止TNF-α处理的fadd 缺陷Jurkat 细胞死亡,EC50值为240 nM。 | |||
T12203L |
Necrostatin 2
|
Others | Others |
Necrostatin 2 is an effective necroptosis inhibitor. Necrostatin 2 is also a RIPK1 inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. |