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Cat. No. | Product Name | Target | Signaling Pathways |
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T81836 |
Mca-SEVNLDAEFK(Dnp)-NH2
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Mca-SEVNLDAEFK(Dnp)-NH2具备一个7-甲氧基香豆素(Mca)荧光基团,由于其与2,4-二硝基苯基(Dnp)间的共振能量转移作用,荧光得到有效猝灭。该化合物主要应用于检测切割Mca与Dnp之间酰胺键的肽酶活性,如BACE-1,其活性导致荧光增强。 | |||
TP1505 |
MCA-SEVNLDAEFR-K(Dnp)-RR, amide
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MCA-SEVNLDAEFR-K(Dnp)-RR, amide is a FRET-based substrate. | |||
T83686 |
Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 acetate
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Mca-SEVNLDAEFR-K(Dnp)-RR-NH2是β-分泌酶(BACE)的荧光底物。当BACE切割该底物时,7-甲氧基香豆素-4-乙酰基(Mca)会被释放出来,其荧光可用于定量BACE活性。Mca的激发/发射最大值分别为328/420 nm。 | |||
T80128 |
RE(EDANS)EVNLDAEFK(DABCYL)R
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Beta-Secretase | Neuroscience |
RE(EDANS)EVNLDAEFK(DABCYL)R为具有EDANS和DABCYL双标记的肽,作为BACE1的荧光底物(Em=360nm,Ex=528nM)。该化合物主要用于评估BACE1酶活性,其活性水平正相关于荧光产生的强度。 |
Cat. No. | Product Name | Species | Expression System |
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TMPJ-00100 |
Artemin Protein, Human, Recombinant
ARTN,Artemin,EVN,Enovin,Neublastin |
Human | E. coli |
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a variable length pre-, or signal sequence, plus a 68 amino acid (aa) proregion and a 113 aa mature segment. Following synthesis and proteolytic processing, mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-β signature cysteine-knot motif. I... | |||
TMPK-00109 |
Artemin Protein, Human, Recombinant (hFc)
ARTNE,ARTN,Neublastin,Enovin,Artemin,NBN,EVN |
Human | HEK293 Cells |
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored GDNF family receptors a (GFRa1, GFRa3) and RET receptor tyrosine kinase. The major mechanism of ARTN action is via binding to a non-signaling co-receptor. The major function of ARTN is to drive the molecule to induce migration and axonal projection from sympathetic neurons. |