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抑制剂 & 化合物

2

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T81836 Mca-SEVNLDAEFK(Dnp)-NH2

Mca-SEVNLDAEFK(Dnp)-NH2具备一个7-甲氧基香豆素(Mca)荧光基团,由于其与2,4-二硝基苯基(Dnp)间的共振能量转移作用,荧光得到有效猝灭。该化合物主要应用于检测切割Mca与Dnp之间酰胺键的肽酶活性,如BACE-1,其活性导致荧光增强。
TP1505 MCA-SEVNLDAEFR-K(Dnp)-RR, amide

MCA-SEVNLDAEFR-K(Dnp)-RR, amide is a FRET-based substrate.
T83686 Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 acetate

Mca-SEVNLDAEFR-K(Dnp)-RR-NH2是β-分泌酶(BACE)的荧光底物。当BACE切割该底物时,7-甲氧基香豆素-4-乙酰基(Mca)会被释放出来,其荧光可用于定量BACE活性。Mca的激发/发射最大值分别为328/420 nm。
T80128 RE(EDANS)EVNLDAEFK(DABCYL)R

Beta-Secretase Neuroscience
RE(EDANS)EVNLDAEFK(DABCYL)R为具有EDANS和DABCYL双标记的肽,作为BACE1的荧光底物(Em=360nm,Ex=528nM)。该化合物主要用于评估BACE1酶活性,其活性水平正相关于荧光产生的强度。

化合物

Mca-SEVNLDAEFK(Dnp)-NH2
Cat.No: T81836
Synonym:
Target:
MCA-SEVNLDAEFR-K(Dnp)-RR, amide
Cat.No: TP1505
Synonym:
Target:
Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 acetate
Cat.No: T83686
Synonym:
Target:
RE(EDANS)EVNLDAEFK(DABCYL)R
Cat.No: T80128
Synonym:
Target: Beta-Secretase
Cat. No. Product Name Species Expression System
TMPJ-00100 Artemin Protein, Human, Recombinant

ARTN,Artemin,EVN,Enovin,Neublastin

Human E. coli
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a variable length pre-, or signal sequence, plus a 68 amino acid (aa) proregion and a 113 aa mature segment. Following synthesis and proteolytic processing, mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-β signature cysteine-knot motif. I...
TMPK-00109 Artemin Protein, Human, Recombinant (hFc)

ARTNE,ARTN,Neublastin,Enovin,Artemin,NBN,EVN

Human HEK293 Cells
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored GDNF family receptors a (GFRa1, GFRa3) and RET receptor tyrosine kinase. The major mechanism of ARTN action is via binding to a non-signaling co-receptor. The major function of ARTN is to drive the molecule to induce migration and axonal projection from sympathetic neurons.

重组蛋白

Artemin Protein, Human, Recombinant
Cat.No: TMPJ-00100
Species: Human
Expression System: E. coli
Artemin Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00109
Species: Human
Expression System: HEK293 Cells
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