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Search Results for " dolastatin-10 "

14

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4677	MMAD Monomethylauristatin D,Demethyldolastatin 10,单甲基澳瑞他汀 D,Monomethyl Dolastatin 10	Microtubule Associated	Cytoskeletal Signaling
	MMAD (Demethyldolastatin 10) 是一种有效的微管蛋白抑制剂，是抗体药物偶联物中的一种毒素有效载荷。
T22631	Dolastatin 10 trifluoroacetate	Others	Others
	Dolastatin 10 trifluoroacetate is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. Dolastatin 10 is found to have an activity to inhibit tubulin polymerization (IC50: 1.2 μM). Besides that, it
T18869	Vat-Cit-PAB-Monomethyl Dolastatin 10	Others	Others
	Vat-Cit-PAB-Monomethyl Dolastatin 10 is an ADC linker-conjugated drug designed to deliver potent antitumor activity. It achieves this through Monomethyl Dolastatin 10, a potent tubulin inhibitor, connected via the Vat-Cit-PAB ADC linker.
T10947	D8-MMAD Monomethylauristatin D D8,Demethyldolastatin 10 D8,Monomethyl Dolastatin 10 D8	Others	Others
	D8-MMAD is a deuterated form of MMAD, which is a microtubule destroyer.
T18315	MC-Sq-Cit-PAB-Dolastatin10	Others	Others
	MC-Sq-Cit-PAB-Dolastatin10 is a potent antitumor drug-linker conjugate for Antibody-Drug Conjugates (ADC), utilizing Dolastatin10 (a tubulin polymerization inhibitor) connected through the MC-Sq-Cit-PAB ADC linker.
T14350	Soblidotin Auristatin PE,TZT-1027	Microtubule Associated	Cytoskeletal Signaling
	Soblidotin (TZT-1027) 是一种微管蛋白聚合抑制剂。它也是一种新型合成的 Dolastatin 10 衍生物。
T9714	Atpenin A5	Potassium Channel	Membrane transporter/Ion channel
	Atpenin A5 是高度特异性的complex II 抑制剂，IC50为 ~10 nM。Dolastatin 10也是有效的mKATP 通道激动剂，具有心脏保活的作用。
T34758	Symplostatin 1 Symplostatin-1
	Symplostatin 1 is a dolastatin 10 analog from the marine cyanobacterium Symploca hydnoides.
T74148	Dolastatinol
	Dolastatinol为dolastatin 10的合成类似物，是一种作用于微管蛋白聚合的低纳摩尔量抑制剂。
T15158	Dolastatin 15 DLS 15	Others	Others
	Dolastatin 15, a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the anti-tubulin agent Dolastatin 10. Dolastatin 15 can be used as an ADC cytotoxin and it induces cell cycle arrest and apoptosis in m
T74349	AGD-0182
	AGD-0182为一种合成分子，是天然微管蛋白结合分子Dolastatin 10的类似物，具备微管破坏剂功能。
T12141	N-Boc-Val-Dil-Dap-Doe	Others	Others
	N-Boc-Val-Dil-Dap-Doe is used to synthesize Dolastatin 10 , which is a potent antimitotic peptide, inhibits tubulin polymerization.
T16490	PF-06380101 Auristatin-0101,Aur0101	Others	Others
	PF-06380101 is an auristatin microtubule inhibitor and is a cytotoxic Dolastatin 10 analogue. When compared to other synthetic auristatin analogues that are used in the preparation of ADCs, PF-06380101 displays excellent potencies in tumor cell proliferat
T39576	DBCO-PEG4-VC-PAB-MMAE DBCO-PEG4-VC-PAB-MMAE
	DBCO-PEG4-VC-PAB-MMAE, an ADC linker comprising DBCO-PEG4-VC-PAB coupled with the tubulin polymerization inhibitor MMAE, serves as a key component in the formulation of antibody-drug conjugates (ADCs). MMAE, a synthetic derivative of dolastatin 10, inhibits tubulin polymerization, acting as a potent mitotic inhibitor.

化合物

Cat.No: T4677

Synonym: Monomethylauristatin D,Demethyldolastatin 10,单甲基澳瑞他汀 D,Monomethyl Dolastatin 10

Target: Microtubule Associated

Dolastatin 10 trifluoroacetate

Cat.No: T22631

Target: Others

Vat-Cit-PAB-Monomethyl Dolastatin 10

Cat.No: T18869

Target: Others

Cat.No: T10947

Synonym: Monomethylauristatin D D8,Demethyldolastatin 10 D8,Monomethyl Dolastatin 10 D8

Target: Others

MC-Sq-Cit-PAB-Dolastatin10

Cat.No: T18315

Target: Others

Cat.No: T14350

Synonym: Auristatin PE,TZT-1027

Target: Microtubule Associated

Cat.No: T9714

Target: Potassium Channel

Cat.No: T34758

Synonym: Symplostatin-1

Cat.No: T74148

Dolastatin 15

Cat.No: T15158

Synonym: DLS 15

Target: Others

Cat.No: T74349

N-Boc-Val-Dil-Dap-Doe

Cat.No: T12141

Target: Others

Cat.No: T16490

Synonym: Auristatin-0101,Aur0101

Target: Others

DBCO-PEG4-VC-PAB-MMAE

Cat.No: T39576

Synonym: DBCO-PEG4-VC-PAB-MMAE

Cat. No.	Product Name	Target	Signaling Pathways
TP1180	Dolastatin 10 尾海兔素10,NSC 376128,DLS 10	Microtubule Associated	Cytoskeletal Signaling
	Dolastatin 10 (DLS 10) 是一种多肽，可以抑制微管蛋白聚合，显示除抗有丝分裂的活性。

天然产物

Dolastatin 10

Cat.No: TP1180

Synonym: 尾海兔素10,NSC 376128,DLS 10

Target: Microtubule Associated

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