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Search Results for " defensin "

26

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T40470	Human β-defensin-2 Human β-defensin-2,HβD-2
	Human β-defensin-2 (HβD-2) is a cationic skin-antimicrobial peptide (SAP) characterized by its small size and rich cysteine content. It is produced by various epithelial cells and exhibits potent antimicrobial properties against gram-negative bacteria and Candida. However, it does not effectively target gram-positive Staphylococcus aureus. Given these characteristics, Human β-defensin-2 serves as a valuable tool in colitis research.
T40550	Human β-defensin-1 Human β-defensin-1,HβD-1
	Human β-defensin-1 (HβD-1) is a cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by epithelial surfaces, circulatory cells, and cells of the reproductive tract. It exhibits antimicrobial activity against a wide range of sperm bacteria.
T39683	Human β-defensin-3 Human β-defensin-3,HβD-3
	Human β-defensin-3 (HβD-3) is an antibiotic antimicrobial peptide synthesized by epithelial cells. It exhibits potent antimicrobial properties and mitigates inflammatory cytokine responses. HβD-3 efficiently targets various microorganisms, displaying IC90 values ranging from 6 to 25 μg/ml.
T41134	Defensin HNP-2 human
	Defensin HNP-2 is a naturally occurring antibiotic and monocyte chemotactic peptide synthesized by human neutrophils.
T41135	Defensin HNP-1 human
	Defensin HNP-1 human is a Human neutrophil peptides (HNPs), involved in endothelial cell dysfunction at the time of early atherosclerotic development.Defensin HNP-1 human can regulate the growth of atherosclerosis.
T35451	β-Defensin-2 (human) (trifluoroacetate salt)
	β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius.2β-Defensin-2 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3It also stimulates calcium mobilization, migration, and proliferation of keratinocytes whe...
T35452	β-Defensin-3 (human) (trifluoroacetate salt)
	β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of the periodontopathogenic and cariogenic bacteria F. nucleatum, S. mutans, S. sobrinus, S. salivarius, and L. casei (MICs = 12.5-100 mg/l). It also inhibits the growth of S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. β-Defensin-3 stimulates gene expression and production of IL-6, IL-10, CXC...
T38103	Defensin HNP-3 (human) (trifluoroacetate salt)
	Defensin HNP-3 is a peptide secreted by human polymorphonuclear leukocytes (PMNs) that has antimicrobial properties. It induces lysis of mammalian cells when used at a concentration of 25 μg/mL. It also inhibits growth of E. faecalis (ED50 = 100 nM) and clinical isolates of P. aeruginosa (MIC90 = 4 μM). HNP-3 binds to recombinant HIV-1 envelope glycoprotein (gp120) and human CD4 (Kds = 52.8 and 34.9 nM, respectively). It also binds to recombinant, immobilized human surfactant protein D (SP-D; Kd...
T35426	β-Defensin-1 (human) (trifluoroacetate salt)
	β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth ofB. adolescentis,L. acidophilus,B. breve,B. vulgatus,L. fermentum,B. longum, andS. thermophilusin an antimicrobial radial diffusion assay.2β-Defensin-1 also inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius, and of susceptibleM. tuberculosisH37Rv but no...
T35453	β-Defensin-4 (human) (trifluoroacetate salt)
	β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils. β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes. It also stimulates calcium mobilization, migration, and pro...
T76501	Defensin HNP 4
	Defensin HNP 4，一种由11个氨基酸组成的HNP-41-11的片段，对多药耐药及非耐药菌株均显示出抑制效果。
T76503	Defensin NP-3A
	Defensin NP-3A (NP-3A; Corticostatin 1) 是一种人粒细胞肽，具有抗 ACTH 活性。防御素是一种具有杀伤活性的抗菌肽。
T80375	Human α-defensin 5	Parasite	Microbiology/Virology
	Human α-defensin 5 是抗病毒肽，能够阻断多种无包膜病毒感染，如AdV、HPV以及多瘤病毒（IC50: HPV16为0.6-1.25 μM）。它通过与病毒衣壳结合来阻止病毒从内体逃逸，并能增强HIV与细胞表面的结合作用。此外，Human α-defensin 5 还具备对抗寄生虫的活性。
T80362	Human α-Defensin 6
	Human α-Defensin 6，含32个半胱氨酸残基的抗菌肽，能够阻止细菌入侵，促进粘膜免疫。该肽通过自组装形成有序的原纤维和纳米网，能随机结合细菌表面蛋白，进而围绕并缠绕细菌。此外，Human α-Defensin 6抑制C. albicans生物膜的形成。
T76063	Beta-defensin 1, pig
	Beta-defensin 1, pig 是一种在猪舌黏膜中主要发现的抗菌肽，对包括大肠杆菌、鼠伤寒沙门氏菌、单核细胞增生性李斯特菌、金黄色葡萄球菌、百日咳博德特氏菌和白色念珠菌在内的多种细菌显示出活性。
T80045	Defensin HNP-3 human	Antibiotic	Microbiology/Virology
	Defensin HNP-3 human 是一种具有抑制金黄色葡萄球菌、铜绿假单胞菌和大肠杆菌活性的细胞毒性抗生素肽。该肽原先以94个氨基酸的preproHNP(1-94)形式合成，随后水解为proHNP(20-94)，最终通过去除阴离子前体转化为成熟形式的HNP(65-94)。
T76070	Defensin HNP-1 human TFA
	Defensin HNP-1 human TFA，一种人中性粒细胞肽(HNPs)，在早期动脉粥样硬化发展中涉及内皮细胞功能障碍。该化合物展现出广泛的抗菌及抗利什曼原虫活性。
T76063L	Beta-defensin 1, pig TFA
	Beta-defensin 1, pig TFA 是一种在猪舌黏膜中主要发现的抗菌肽，对多种细菌如大肠杆菌、鼠伤寒沙门氏菌、单核细胞增生性李斯特菌、金黄色葡萄球菌、百日咳博德特氏菌和白色念珠菌等显示出抗菌活性。
T80323	Bovine neutrophil beta-defensin 12 BNBD-12
	Bovine neutrophil beta-defensin 12，一种牛中性粒细胞来源的抗菌肽，展现针对大肠杆菌(Escherichia coli)和金黄色葡萄球菌(Staphylococcus aureus)的抗菌活性。
T76064	Beta-defensin 103 isoform X1, pig
	Beta-defensin 103 isoform X1, pig 是一种抗菌肽、在多种生物体内被发现，参与了先天性免疫防线。
T76064L	Beta-defensin 103 isoform X1, pig TFA
	Beta-defensin 103 isoform X1, pig TFA 是一种抗菌肽、在多种生物体内被发现，参与了先天性免疫防线。
T14781	Brilacidin PMX 30063	Others	Others
	Brilacidin is a nonpeptidic anti-infective in a new class of defensin mimetics used for the research of eye infections.
T80340	ROAD-1
	ROAD-1是一种α-防御素，源于恒河猴口腔粘膜。该化合物展现出对金黄色葡萄球菌、大肠杆菌和白色念珠菌的抗菌活性。
T38608	Brilacidin tetrahydrochloride PMX 30063 tetrahydrochloride
	Brilacidin tetrahydrochloride (PMX 30063 tetrahydrochloride) is a defensin mimetic antibiotic compound, exhibiting potent anti-infective antimicrobial activity against a range of bacteria. It demonstrates MIC90 values of 1 μg/mL and 8 μg/mL against the Gram-positive bacteria Streptococcus pneumoniae and Streptococcus viridans, respectively. Additionally, it has a MIC90 value of 8 μg/mL for the Gram-negative bacteria Haemophilus influenzae and a MIC90 value of 4 μg/mL for Pseudomonas aeruginosa.
T81295	Retrocyclin-1
	Retrocyclin-1是一种θ防御素，具有识别并结合含碳水化合物表面分子的能力，能够保护细胞抵御HIV-1感染。该化合物对胎球蛋白、gp120（Kd=35.4 nM）、CD4（Kd=31 nM）以及半乳糖神经酰胺（Kd=24.1 nM）展现出高度亲和性。
T80255	CHRG01
	CHRG01为源自人b-防御素3(hBD3)第54至67个C末端氨基酸，并将所有Cys残基替换为Ser以移除所有二硫键的生物活性肽。与hBD3类似，CHRG01展现出静电依赖性的抗菌性质。

化合物

Human β-defensin-2

Cat.No: T40470

Synonym: Human β-defensin-2,HβD-2

Human β-defensin-1

Cat.No: T40550

Synonym: Human β-defensin-1,HβD-1

Human β-defensin-3

Cat.No: T39683

Synonym: Human β-defensin-3,HβD-3

Defensin HNP-2 human

Cat.No: T41134

Defensin HNP-1 human

Cat.No: T41135

β-Defensin-2 (human) (trifluoroacetate salt)

Cat.No: T35451

β-Defensin-3 (human) (trifluoroacetate salt)

Cat.No: T35452

Defensin HNP-3 (human) (trifluoroacetate salt)

Cat.No: T38103

β-Defensin-1 (human) (trifluoroacetate salt)

Cat.No: T35426

β-Defensin-4 (human) (trifluoroacetate salt)

Cat.No: T35453

Defensin HNP 4

Cat.No: T76501

Defensin NP-3A

Cat.No: T76503

Human α-defensin 5

Cat.No: T80375

Target: Parasite

Human α-Defensin 6

Cat.No: T80362

Beta-defensin 1, pig

Cat.No: T76063

Defensin HNP-3 human

Cat.No: T80045

Target: Antibiotic

Defensin HNP-1 human TFA

Cat.No: T76070

Beta-defensin 1, pig TFA

Cat.No: T76063L

Bovine neutrophil beta-defensin 12

Cat.No: T80323

Synonym: BNBD-12

Beta-defensin 103 isoform X1, pig

Cat.No: T76064

Beta-defensin 103 isoform X1, pig TFA

Cat.No: T76064L

Cat.No: T14781

Synonym: PMX 30063

Target: Others

Cat.No: T80340

Brilacidin tetrahydrochloride

Cat.No: T38608

Synonym: PMX 30063 tetrahydrochloride

Cat.No: T81295

Cat.No: T80255

Cat. No.	Product Name	Target	Signaling Pathways
T80344	Aeschna defensin
	Aeschna defensing是源自蜻蜓水生幼虫血淋巴的抗菌肽，对革兰氏阳性菌具有显著活性。
TQ0216	Ercalcitriol 1α,25-Dihydroxy Vitamin D2	Others	Others
	Ercalcitriol (1α,25-Dihydroxy Vitamin D2) 是维生素 D2 的活性代谢物。 Ercalcitriol 作为维生素 D 的生理活化形式，通过调节正常细胞和转化细胞中的导管素抗菌肽 (CAMP) 和防御素 β-4 (DEFB4) 基因来增强免疫力，从而对抗病原体感染。

天然产物

Aeschna defensin

Cat.No: T80344

Cat.No: TQ0216

Synonym: 1α,25-Dihydroxy Vitamin D2

Target: Others

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