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Cat. No. | Product Name | Target | Signaling Pathways |
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T27998 |
MDK-4204
Anticancer AgentI,MDK 4204,Anticancer Agent I,MDK4204,Anticancer Agent-I |
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MDK-4204, an anticancer agent, shows significant anti-cancer activity with IC50 values of 8.8 µM and 9.5 µM in PC-3 and DU-145 cells, respectively. | |||
T63391 |
Calpain Inhibitor-2
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Calpain Inhibitor-2 是具有亲脂性的钙蛋白酶抑制剂,与黑色素瘤细胞系(A-375和B-16F1)和PC-3前列腺癌细胞相比,他们在体外具有中等到良好的抗增殖效果。Calpain Inhibitor-2 中的化合物3,在基质胶细胞侵袭测定中以2μM 浓度能够抑制了80%的DU-145细胞侵袭。 | |||
T67909 |
TAK1 inhibitor
compound 13a |
Topoisomerase | DNA Damage/DNA Repair |
TAK1 inhibitor 是一种抑制剂,对MCF-7、A549 、DU-145 、MDA MB-231有抑制作用,IC50分别为 0.021、0.14、0.064 、0.19 。化合物13 具有较好的抑菌活性,麦克风范围为93.7 ~ 46.9μg / mL,麦克风范围为7.8 ~ 5.8μg / mL。 | |||
T64157 | OXi8007 | ||
OXi8007 是一种水溶性磷酸盐,是 OXi8006(一种微管蛋白结合化合物)的前药。OXi8007 是一种具有潜在抗癌活性的血管破坏剂。它被发现对DU-145肿瘤细胞系具有强烈的细胞毒性,它也被证明了对肿瘤血管系统的显著干扰。 | |||
T70222 | Ethonafide | ||
Ethonafide is an anthracene-containing derivative of amonafide that belongs to the azonafide series of anticancer agents. The lack of cross-resistance in multidrug-resistant cancer cell lines and the absence of a quinone and hydroquinone moiety make ethonafide a potentially less cardiotoxic replacement for existing anthracene-containing anticancer agents. Ethonafide was cytotoxic against three human prostate cancer cell lines at nanomolar concentrations. Ethonafide was found to be better tolerat... | |||
T71252 |
PC-046
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PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory activity in a variety of tumor types in vitro, and efficacy in SCID mice was shown in human tumor xenografts of MV-4-11 acute myeloid leukemia, MM.1S multiple myeloma, and DU-145 prostate cancer. Pharmacokinetic studies demonstrated relatively high oral bioavailability (71 %) with di... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T2S1158 |
4,5-Dicaffeoylquinic acid
3,4-Dicaffeoylquinic acid,异绿原酸C(4,5),Isochlorogenic acid C |
Others; HBV; Endogenous Metabolite | Metabolism; Microbiology/Virology; Others |
4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) 是一种天然产物,有抗病毒、抗肝毒性活性。 | |||
TN4963 | Scillascillin | Others | Others |
Scillascillin has anticancer activity, it is significantly active against human cancer cell lines MCF-7 (breast cancer) and DU-145 (prostate cancer) with inhibitory concentration (IC)50 values 9.59 and 11.32 ug/ml respectively. | |||
TMA1841 | Dihydrodaidzin | Others | Others |
Dihydrodaidzin shows cytotoxic activities against human stomach carcinoma (Hs 740.T, Hs 756 T), breast adenocarcinoma (Hs 578 T, Hs 742.T), and prostate carcinoma (DU 145, LNCaP-FGC) cell lines. | |||
T1174 |
Topotecan hydrochloride
SKF 104864A,SKFS 104864A,NSC609699,Nogitecan HCl,NSC 609669,盐酸拓扑替康,Topotecan HCl |
Apoptosis; Topoisomerase; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair |
Topotecan hydrochloride (NSC609699) 是一种具有抗癌活性的拓扑异构酶I 抑制剂。 |