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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4042 |
Talabostat mesylate
Val-boroPro,PT100 |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Talabostat mesylate (PT100) 是一种具有口服活性和非选择性的二肽基肽酶 IV 抑制剂(IC50< 4 nM;Ki= 0.18 nM)。Talabostat mesylate 是成纤维细胞活化蛋白的第一个临床抑制剂(IC50= 560 nM),抑制 DPP8/9 (IC50= 4/11 nM;Ki= 1.5/0.76 nM),静息细胞脯氨酸二肽酶(IC50= 310 nM)、DPP2 和一些其他 DASH 家族酶。Talabostat mesylate 具有抗肿瘤和造血刺激活性 。 | |||
T4467 |
UAMC00039 dihydrochloride
UAMC 00039 dihydrochloride |
Proteasome | Proteases/Proteasome; Ubiquitination |
UAMC00039 dihydrochloride 是可逆、竞争性的 dipeptidyl peptidase II 高效抑制剂,IC50=为0.48 nM。 | |||
T37861 | Talabostat | ||
Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 and some other DASH family enzymes essentially as potently as it inhibits DPP-IV[1]. Talabostat stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. The inhibition of two serine proteases, DPP8 and DPP9,... | |||
T11864 |
Iptacopan
LNP023 |
Others | Others |
Iptacopan (LNP023) 是一种与factor B 亲和力较高的抑制剂。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02737 |
DPP2 Protein, Mouse, Recombinant (His)
dipeptidyl-peptidase 7,DPPII,QPP,Dpp2<... |
Mouse | HEK293 Cells |
DPP2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.7 kDa and the accession number is Q9ET221. | |||
TMPY-00777 |
DPP2 Protein, Human, Recombinant (His)
DPP2,DPPII,QPP,dipeptidyl-peptida... |
Human | HEK293 Cells |
DPP2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.6 kDa and the accession number is Q9UHL4. |