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Search Results for " dpp-4-in-1 "

14

抑制剂 & 化合物

1

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Cat. No.	Product Name	Target	Signaling Pathways
T61422	DPP-4-IN-1
	DPP-4-IN-1 (compound d1) is a highly potent inhibitor of DPP-4 (dipeptidyl peptidase 4) with an IC 50 of 49 nM, making it suitable for diabetes research [1]. It shares structural similarities to Alogliptin and can be effectively utilized for studying diabetes-related mechanisms.
T6999	Teneligliptin hydrobromide Teneligliptin hydrobromide anhydrous,MP-513 (hydrobromide)	Others; Proteasome; DPP-4	Others; Proteases/Proteasome; Ubiquitination
	Teneligliptin hydrobromide (MP-513(hydrobromide)) 是β2肾上腺素能受体 (β2AR) 阻滞剂，具有抗高血压、抗氧化、清除自由基的活性。
T0242	Sitagliptin 西他列汀,MK0431,西格列汀	Proteasome; DPP-4; Autophagy	Autophagy; Proteases/Proteasome; Ubiquitination
	Sitagliptin (MK0431) 是一种有效的 DPP4抑制剂，在 Caco-2 细胞中，IC50值为 19 nM。它是一种新型口服降糖药，可单独使用或与二甲双胍或噻唑烷二酮联合用于治疗 2 型糖尿病。
T61018	DPP-4-IN-2
	DPP-4-IN-2 (compound b2) 是 Alogliptin 的结构类似物，可以用于研究糖尿病。DPP-4-IN-2 是二肽基肽酶 4 (DPP-4)的有效抑制剂，IC50值为 79 nM。
T41250	Teneligliptin hydrobromide hydrate
	Teneligliptin hydrobromide hydrate 是一种有效的 DPP-4抑制剂，可在体外竞争性抑制人血浆、大鼠血浆和重组人 DPP-4 ，IC50值约为 1 nM。
T74592	Sitagliptin fenilalanil hydrochloride
	Sitagliptin fenilalanil hydrochloride 是一种二肽氨基肽酶 (DPP-4) 抑制剂。
T74528	DPP-4/GPR119 modulator 1
	DPP-4/GPR119 modulator 1 (Compound 22) 是一种具有口服活性的二肽基肽酶 IV (DPP-IV) 抑制剂和 GPR119激动剂。DPP-4/GPR119 modulator 1 具有降血糖作用，抑制hERG 通道，IC50值为 4.9 µM。DPP-4/GPR119 modulator 1 可用于糖尿病的研究。
T76922	Begelomab
	Begelomab (SAND-26) 是一种针对 DPP-4/CD26的鼠IgG2b 单克隆抗体。 Begelomab 可用于严重难治性特发性炎症性肌病的研究。
T37522	Teneligliptin
	Teneligliptin (MP-513) is a potent chemotype prolylthiazolidine-based DPP-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM. Teneligliptin (MP-513) inhibits all these DPP-4 enzymes in a concentration-dependent manner. The IC50s of Teneligliptin (MP-513) for rhDPP-4, human plasma, and rat plasma are 0.889, 1.75, and 1.35 nM, respectively. A study of enzyme inhibition kinetics is conducted for Teneligliptin (M...
T73875	Fotagliptin benzoate
	Fotagliptin benzoate，作为一种二肽基肽酶IV (DPP-4) 抑制剂（IC50=2.27 nM），在大鼠和狗中展现了安全性，适用于2型糖尿病的研究。
T79256	DPP-4-IN-8
	DPP-4-IN-8 (compound 27) 是一种高效的选择性DPP4抑制剂，具有 0.96 μM 的 Ki。该化合物能够抑制 Caco-2 和 HepG-2 细胞中的 DPP4 二肽酶活性，并剂量依赖性地降低 TNF-α、IL-6 和 IL-1β 的表达水平[1]。
T78571	Albiglutide fragment TFA GLP-1-Gly8 TFA,GLP-1 (7-36) analog TFA
	Albiglutide fragment (GLP-1 (7-36) analog) TFA为Albiglutide活性片段，代表胰高血糖素样肽-1(GLP-1)模拟物，属长效GLP-1受体激动剂。由GLP-1二聚体抗DPP-4特性与人白蛋白基因融合而成，本化合物在降低糖化血红蛋白(A1C)方面表现显著，主要应用于2型糖尿病(T2D)的相关研究。
T37861	Talabostat
	Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 and some other DASH family enzymes essentially as potently as it inhibits DPP-IV[1]. Talabostat stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. The inhibition of two serine proteases, DPP8 and DPP9,...
T35599	Neuropeptide Y (3-36) (human, rat) (trifluoroacetate salt)
	Neuropeptide Y (NPY) (3-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion. NPY (3-36) is an endogenous peptide produced by cleavage of NPY by dipeptidyl peptidase 4 (DPP-4). It binds selectively to the NPY receptor Y2 (Ki = 0.41 nM in CHP 234 cells) over the Y1 receptor, where it does not bind at concentrations up to 1 μM. NPY (3-36) (0.1 nM) increases migration of human umbilical vein endothelial...

化合物

Cat.No: T61422

Teneligliptin hydrobromide

Cat.No: T6999

Synonym: Teneligliptin hydrobromide anhydrous,MP-513 (hydrobromide)

Target: Others, Proteasome, DPP-4

Cat.No: T0242

Synonym: 西他列汀,MK0431,西格列汀

Target: Proteasome, DPP-4, Autophagy

Cat.No: T61018

Teneligliptin hydrobromide hydrate

Cat.No: T41250

Sitagliptin fenilalanil hydrochloride

Cat.No: T74592

DPP-4/GPR119 modulator 1

Cat.No: T74528

Cat.No: T76922

Cat.No: T37522

Fotagliptin benzoate

Cat.No: T73875

Cat.No: T79256

Albiglutide fragment TFA

Cat.No: T78571

Synonym: GLP-1-Gly8 TFA,GLP-1 (7-36) analog TFA

Cat.No: T37861

Neuropeptide Y (3-36) (human, rat) (trifluoroacetate salt)

Cat.No: T35599

Cat. No.	Product Name	Target	Signaling Pathways
T81898	Lyciumamide A
	DPP-IV-IN-5，一种从枸杞果实中分离得到的化合物，对过氧化物酶体增殖物激活受体(PPARγ)展示中等拮抗活性，其EC50值介于10.09至44.26 μM，同时对二肽基肽酶-4 (DPPIV)亦有抑制作用，IC50值为47.13 μM。

天然产物

Cat.No: T81898

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