Cat. No. | Product Name | Target | Signaling Pathways |
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T4142 |
PCC0208009
IDO inhibitor 1,DO-IN-2,IDO-IN-2 |
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
PCC0208009 (IDO-IN-2) 是一种有效的 IDO 抑制剂,其在 HeLa 细胞中的 IC50=4.52 nM。它调节 ACC 和杏仁核的突触可塑性,减少神经性疼痛和合并症。 | |||
T2196 |
Fipronil
氟虫腈,Fluocyanobenpyrazole,Termidor |
P450; GluCls; GABA Receptor | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
Fipronil (Fluocyanobenpyrazole) 是昆虫GABA 受体的选择性拮抗剂,可抑制蟑螂神经元中谷氨酸盐引起的脱敏和非脱敏。在分离的大鼠肝微粒体中,它诱导细胞色素 P450 (CYP) 亚型CYP1A1/2、CYP2B1/2和CYP3A1/2的活性。 | |||
T26718 |
AZD6370
AZD-6370,AZD 6370 |
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AZD-6370 is a glucokinase activator. AZD-6370 decreases fasting and postprandial glucose in type 2 diabetes mellitus patients with effects influenced by dosing regimen and food. AZD-6370 do not affect the central counterregulatory response to hypoglycemia | |||
T71385 | Aroplatin | ||
Aroplatin is a synthetic liposomal formulation of bis-neodecanoate diaminocyclohexane platinum (NDDP), a third-generation platinum complex analogue of cisplatin, with potential antineoplastic activity. After displacement of the 2 long-chain aliphatic leaving groups (neodecanoic acid), platinum diaminocyclohexane (DACH) complexes become highly reactive and alkylate macromolecules, forming both inter- and intra-strand DNA crosslinks and inhibiting DNA synthesis, which results in tumor cell cytotox... | |||
T62582 |
WEHI-150
|
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WEHI-150是一种米托蒽醌类似物,作为DNA链间交联剂,具有12.5小时的半衰期。该化合物能够在CpG序列上形成共价加合物,对甲基化CpG位点表现出选择性。甲醛激活的WEHI-150能够诱导DNA链间交联,并表现出浓度依赖性的转录阻断作用。此外,WEHI-150还能在新的DNA序列中形成加合物,这不涉及与鸟嘌呤N-2的相互作用。 | |||
T36504 |
STY-BODIPY
STY-BODIPY,Styrene-BODIPY |
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STY-BODIPY is a styrene-conjugated fluorogenic probe for radical-trapping antioxidant (RTA) activity.1 Co-autoxidation of the STY-BODIPY signal carrier and a hydrocarbon co-substrate can be quantified by monitoring the loss of absorbance at 571 nm. STY-BODIPY has been used to measure the activity of RTAs, as well as the kinetics and stoichiometry of RTA reactions in cell-free assays.1,2,3References1. Haidasz, E.A., Van Kessel, A.T.M., and Pratt, D.A. A continuous visible light spectrophotometric... |