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Cat. No.	Product Name	Target	Signaling Pathways
T62648	DNA-PK-IN-1
	DNA-PK-IN-1 是一种 DNA-PK 的有效抑制剂。DNA 依赖性蛋白激酶 (DNA-PK) 是一种由 Ku70/Ku80 异二聚体和 DNA 依赖性蛋白激酶催化亚基 (DNA-PKcs) 组成的 DNA-PK 酶复合物。DNA-PK-IN-1 具有潜力进行癌症疾病的研究。
T1826	PI3K-IN-1 Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409	DNA-PK; PI3K	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	PI3K-IN-1 (Voxtalisib Analogue) 是 PI3K 抑制剂，PI3K-IN-1(25 μM) 能够阻断 PI3K/Akt 信号通路。
T9498	BAY-8400	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	BAY-8400是一种具有口服活性、有效和选择性 DNA 依赖蛋白激酶 (DNA-PK) 抑制剂(IC50=81 nM)，与靶向α疗法联合使用显示协同疗效。BAY-8400 可用于癌症研究。
T62034	DNA-PK-IN-7
	DNA-PK-IN-7 是有效的 DNA-PK 抑制剂，IC50为 1 nM (WO2021104277A1, compound 5)。
T61533	DNA-PK-IN-9
	DNA-PK-IN-9 (also known as compound YK6) is a highly potent inhibitor of DNA-dependent protein kinase (DNA-PK), displaying an IC50 value of 10.47 nM. DNA-PK-IN-9 holds significant potential in anticancer research [1].
T61633	DNA-PK-IN-2
	DNA-PK-IN-2 is a highly effective inhibitor of DNA-dependent protein kinase (DNA-PK), which is a complex enzyme composed of Ku70/Ku80 heterodimer and DNA-PK catalytic subunit (DNA-PKcs). With its potential applications in cancer research, DNA-PK-IN-2 demonstrates promise as a valuable tool for studying cancer diseases [1].
T79165	DNA-PK-IN-10	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	DNA-PK-IN-10是一种DNA-PK抑制剂, 主要应用于乳腺癌与非小细胞肺癌的研究。
T61857	DNA-PK-IN-4
	DNA-PK-IN-4 (WO2021209055A1, compound 27), an imidazolinone derivative compound, is a highly effective inhibitor of DNA-PK, specifically targeting DNA-PKcs activity. By inhibiting DNA-PKcs, the compound significantly impairs tumor DNA repair mechanisms and triggers apoptosis in cells. With its potential application in cancer research, DNA-PK-IN-4 holds promise for further investigation [1].
T61370	DNA-PK-IN-6
	DNA-PK-IN-6, a robust DNA-PK inhibitor, effectively hampers the activity of DNA-PKcs, thereby significantly impairing the DNA repair mechanism in tumors and instigating apoptosis in cells. Additionally, DNA-PK-IN-6 amplifies the responsiveness of tumor tissues to radiotherapy, overcomes the challenge of drug resistance, and augments its inhibitory impact on a diverse range of solid and hematological tumors[1].
T61751	DNA-PK-IN-3
	DNA-PK-IN-3 is a highly potent inhibitor of DNA-PK. This compound exerts a synergistic effect when combined with radiotherapy and chemotherapy, resulting in enhanced therapeutic outcomes and significant inhibition of tumor growth. Furthermore, DNA-PK-IN-3 demonstrates remarkable efficacy in reducing damage to normal cells, effectively minimizing adverse side effects. Due to these compelling properties, DNA-PK-IN-3 holds great potential for cancer research applications[1].
T61828	DNA-PK-IN-8
	DNA-PK-IN-8（化合物DK1）是一种高效、选择性且口服活性的DNA依赖蛋白激酶 (DNA-PK) 抑制剂，其IC50值为0.8 nM。与Doxorubicin联合应用时，该化合物能在多种癌细胞中展现出协同的抗增殖效应，并能显著地抑制HL-60肿瘤生长。
T61587	ATR-IN-15
	ATR-IN-15 (compound 1) is a highly potent and orally active inhibitor of ATR kinase with an IC50 of 8 nM. Additionally, ATR-IN-15 demonstrates inhibitory activity against several targets, including human colon tumor cells LoVo, DNA-PK, and PI3K, with IC50 values of 47, 663, and 5131 nM, respectively [1].
T75245	Canfosfamide
	Canfosfamide (TLK-286) 是一种谷胱甘肽类似物前体药物，由谷胱甘肽 S-转移酶 P1-1 激活，诱导细胞凋亡 (apoptosis)。Canfosfamide 还抑制 DNA 依赖性蛋白激酶 (DNA-PK) 的催化激酶活性。Canfosfamide 在活化后产生一种抗癌烷基化剂和谷胱甘肽衍生物。Canfosfamide 可用于恶性肿瘤的研究。
T78756	Yhhu6669	HBV	Microbiology/Virology
	Yhhu6669为抗HBV药物，能够抑制HBVDNA。该化合物通过诱导无DNA衣壳的形成，从而抑制HBV复制，且能有效降低AAV/HBV感染小鼠中的HBVDNA及HBcAg水平，展现出优良的药代动力学特性。

化合物

Cat.No: T62648

Cat.No: T1826

Synonym: Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409

Target: DNA-PK, PI3K

Cat.No: T9498

Target: DNA-PK

Cat.No: T62034

Cat.No: T61533

Cat.No: T61633

Cat.No: T79165

Target: DNA-PK

Cat.No: T61857

Cat.No: T61370

Cat.No: T61751

Cat.No: T61828

Cat.No: T61587

Cat.No: T75245

Cat.No: T78756

Target: HBV

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